Journal of Natural Products, Journal Year: 2024, Volume and Issue: 87(4), P. 1246 - 1267
Published: March 7, 2024
Ginsenosides, the primary pharmacologically active constituents of
Language: Английский
Biology, Journal Year: 2020, Volume and Issue: 9(9), P. 252 - 252
Published: Aug. 28, 2020
Natural products, including organisms (plants, animals, or microorganisms) have been shown to possess health benefits for animals and humans. According the estimation of World Health Organization, in developing countries, 80% population has still depended on traditional medicines folk which are mostly prepared from plant prevention treatment diseases. Traditional medicine extracts proved be more affordable, clinically effective relatively less adverse effects than modern drugs. Literature shows that attention application phytochemical constituents medicinal plants pharmaceutical industry increased significantly. Plant-derived secondary metabolites small molecules macromolecules biosynthesized steroids, alkaloids, phenolic, lignans, carbohydrates glycosides, etc. a diversity biological properties beneficial humans, such as their antiallergic, anticancer, antimicrobial, anti-inflammatory, antidiabetic antioxidant activities Diabetes mellitus is chronic disease result metabolic disorders pancreas β-cells hyperglycemia. Hyperglycemia can caused by deficiency insulin production pancreatic (Type 1 diabetes mellitus) insufficiency face resistance 2 mellitus). The current medications focus controlling lowering blood glucose levels vessel normal level. However, most drugs many side causing some serious medical problems during period treating. Therefore, used long time play an important role alternative medicines. Moreover, past few years, new bioactive isolated showed activity with efficacy oral hypoglycemic agents clinical therapy. performed good practice showing bright future therapy mellitus. Organization pointed out this its complications not only major challenge future, but essential if all attained. paper briefly reviews active compounds, pharmacological popular widely diabetic treatment. Morphological data V-herb database each species was also included identification.
Language: Английский
Citations
363
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: Aug. 4, 2023
Inhibition of tumor growth and normalization immune responses in the microenvironment (TME) are critical issues for improving cancer therapy. However, treatment glioma, effective nanomedicine has limited access to brain because blood-brain barrier (BBB). Previously, we demonstrated nano-sized ginseng-derived exosome-like nanoparticles (GENs) consisting phospholipids including various bioactive components, evaluated anti-tumor T cells Tregs inhibit progression. It was found that enhanced targeting ability GENs BBB glioma induced a significant therapeutic effect exhibited strong efficacy recruiting M1 macrophage expression TME. were be successful candidates therapeutics both vitro vivo, suggesting excellent potential inhibiting progression regulating tumor-associated macrophages (TAMs).
Language: Английский
Citations
81
Experimental Gerontology, Journal Year: 2022, Volume and Issue: 161, P. 111731 - 111731
Published: Feb. 7, 2022
Language: Английский
Citations
77
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4772 - 4772
Published: March 1, 2023
Depression is a mental health disorder that develops as result of complex psycho-neuro-immuno-endocrinological disturbances. This disease presents with mood disturbances, persistent sadness, loss interest and impaired cognition, which causes distress to the patient significantly affects ability function have satisfying family, social professional life. requires comprehensive management, including pharmacological treatment. Because pharmacotherapy depression long-term process associated risk numerous adverse drug effects, much attention paid alternative therapy methods, phytopharmacotherapy, especially in treating mild or moderate depression. Preclinical studies previous clinical confirm antidepressant activity active compounds plants, such St. John’s wort, saffron crocus, lemon balm lavender, less known European ethnopharmacology, roseroot, ginkgo, Korean ginseng, borage, brahmi, mimosa tree magnolia bark. The these plants exert antidepressive effects similar mechanisms those found synthetic antidepressants. description phytopharmacodynamics includes inhibiting monoamine reuptake oxidase complex, agonistic antagonistic on multiple central nervous system (CNS) receptors. Moreover, it noteworthy anti-inflammatory effect also important mentioned above light hypothesis immunological disorders CNS are significant pathogenetic factor narrative review results from traditional, non-systematic literature review. It briefly discusses pathophysiology, symptomatology treatment depression, particular focus role phytopharmacology its provides action revealed experimental ingredients isolated herbal antidepressants selected confirming their effectiveness.
Language: Английский
Citations
56
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: July 21, 2024
Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.
Language: Английский
Citations
33
Journal of Advanced Research, Journal Year: 2024, Volume and Issue: 66, P. 303 - 328
Published: Jan. 7, 2024
Rare ginsenosides (Rg3, Rh2, C-K, etc.) refer to a group of dammarane triterpenoids that exist in low natural abundance, mostly produced by deglycosylation or side chain modification via physicochemical processing metabolic transformation gut, and last but not least, exhibited potent biological activity comparing the primary ginsenosides, which lead high concern both research development ginseng ginsenoside-related nutraceutical products. Nevertheless, comprehensive review on these promising compounds is available yet. Review In this review, recent advances (RGs) were summarized dealing with structurally diverse characteristics, traditional usage, drug discovery situation, clinical application, pharmacological effects underlying mechanisms, structure-activity relationship, toxicity, stereochemistry properties, production strategies. Key Scientific Concepts A total 144 RGs skeletons bioactivities isolated from Panax species. acted as ligands some specific receptors, such bile acid steroid hormone adenosine diphosphate (ADP) receptors. The showed including immunoregulatory adaptogen-like effect, anti-aging anti-tumor well their cardiovascular cerebrovascular system, central nervous obesity diabetes, interaction gut microbiota. Clinal trials indicated potential RGs, while quality data remains inadequate, no obvious was founded. properties induced at C (20) also addressed pharmacodynamics behaviors, together state-of-art analytical strategies for identification saponin stereoisomers. Finally, batch preparation targeted designated heating acid/ alkaline-assisted processes, enzymatic biotransformation biosynthesis discussed. Hopefully, present can provide more clues extensive understanding future in-depth originated worldwide recognized plants.
Language: Английский
Citations
25
Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155472 - 155472
Published: Feb. 24, 2024
Language: Английский
Citations
20
Food Chemistry, Journal Year: 2024, Volume and Issue: 463, P. 141111 - 141111
Published: Sept. 6, 2024
Language: Английский
Citations
15
Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 225, P. 120458 - 120458
Published: Jan. 8, 2025
Language: Английский
Citations
3
Journal of Ginseng Research, Journal Year: 2020, Volume and Issue: 45(1), P. 32 - 40
Published: Sept. 17, 2020
Traditional medicinal practices have used natural products such as adaptogens to treat inflammatory, autoimmune, neurodegenerative, bacterial, and viral diseases since the early days of civilization. Panax ginseng Myer is a common herb in East Asian countries for millennia, especially Korea, China, Japan. Numerous studies indicate that can modulate immune system thereby prevent diseases. Although human comprises many different types cells, multiple suggest each type cell be controlled or stimulated by its derivatives. Provisional lists ginseng's potential use against viruses, bacteria, other microorganisms it may prove valuable pharmaceutical resource, particularly if higher-quality evidence found. Here, we reviewed role an immune-modulating agent attempt provide starting point future on system.
Language: Английский
Citations
92