Hyperlocal US PM2.5 Trace Elements Super-learned DOI Creative Commons
Heresh Amini,

Mahdieh Danesh-Yazdi,

Qian Di

et al.

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: Sept. 14, 2022

Abstract Particulate matter with aerodynamic diameter less than 2.5 µm (PM2.5) is a multi-million human silent killer worldwide and contains numerous trace elements (TEs). Understanding TEs relative toxicity largely limited by lack of data. Here, we used ensembles machine learning models to generate ~163 billion predictions estimating annual means ten TEs, namely bromine, calcium, copper, iron, potassium, nickel, lead, silicon, vanadium, zinc across 3,535 contiguous US urban areas at 50-m spatial resolution 1-km in non-urban from 2000-2019. Our results highlight substantial intra-urban inter-urban variations, shrinkages, stagnations, or expansions hotspots, trends 20 years. These data open avenues for future research epidemiological studies environmental justice analyses more.

Language: Английский

Air pollution, depressive and anxiety disorders, and brain effects: A systematic review DOI Creative Commons
Clara G. Zundel,

Patrick Ryan,

Cole Brokamp

et al.

NeuroToxicology, Journal Year: 2022, Volume and Issue: 93, P. 272 - 300

Published: Oct. 21, 2022

Language: Английский

Citations

108
Effects of ambient fine particulates, nitrogen dioxide, and ozone on maturation of functional brain networks across early adolescence DOI Creative Commons
Devyn L. Cotter, Claire Campbell,

Kirthana Sukumaran

et al.

Environment International, Journal Year: 2023, Volume and Issue: 177, P. 108001 - 108001

Published: June 1, 2023

Air pollution is linked to neurodevelopmental delays, but its association with longitudinal changes in brain network development has yet be investigated. We aimed characterize the effect of PM2.5, O3, and NO2 exposure at ages 9–10 years on functional connectivity (FC) over a 2-year follow-up period, focus salience (SN), frontoparietal (FPN), default-mode (DMN) networks as well amygdala hippocampus given their importance emotional cognitive functioning. A sample children (N = 9,497; 1–2 scans each for total 13,824 scans; 45.6% two scans) from Adolescent Brain Cognitive Development (ABCD) Study® were included. Annual averages pollutant concentrations assigned child's primary residential address using an ensemble-based modeling approach. Resting-state MRI was collected 3T scanners. First, developmental linear mixed-effect models performed typical FC within our sample. Next, single- multi-pollutant constructed examine between intra-network, inter-network, subcortical-to-network change time, adjusting sex, race/ethnicity, income, parental education, handedness, scanner type, motion. Developmental profiles included intra-network integration DMN FPN inter-network SN-FPN; along segregation SN more broadly. Higher PM2.5 resulted greater time. In contrast, higher O3 less Lastly, led period. Taken together, childhood relate distinct patterns maturation This first study show outdoor ambient air during development.

Language: Английский

Citations

33
Neurotoxicity of the air-borne particles: From molecular events to human diseases DOI
Fang Liu, Chunyan Liu, Yin Liu

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 457, P. 131827 - 131827

Published: June 10, 2023

Language: Английский

Citations

26
Contribution and Effects of PM2.5-Bound Lead to the Cardiovascular Risk of Workers in a Non-Ferrous Metal Smelting Area Considering Chemical Speciation and Bioavailability DOI Creative Commons

Xiaochong He,

Qiting Zhao,

Xuyang Chai

et al.

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(4), P. 1743 - 1754

Published: Jan. 23, 2023

Lead is known to have toxic effects on the cardiovascular system. Owing its high concentration, transmission range, and absorption efficiency in organisms, inhalation of fine particulate matter (PM2.5)-bound lead (PM2.5-Pb) may cause significant damage. However, contribution adverse PM2.5-Pb workers residents non-ferrous metal smelting areas are not fully understood. In this work, concentration chemical speciation were analyzed determine pollution characteristics at a typical site. A panel study conducted among factory revealed that exposure makes an important human Pb. Although suggested poor water solubility, bioavailability was observed mice (tissue average value: 50.1%, range: 31.1–71.1%) subjected for 8 weeks. Based data, relationship between damage evaluated animal simulation experiments. Finally, threshold cardiovascular-specific risk assessment model established area. Our project only accurately estimates PM2.5-bound heavy metals system but also offers scientific basis future prevention therapy PM2.5-Pb-related diseases.

Language: Английский

Citations

25
PM2.5-induced ferroptosis by Nrf2/Hmox1 signaling pathway led to inflammation in microglia DOI
Haiyun Wei, Chao Chen,

Fanglin Di

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 352, P. 124130 - 124130

Published: May 8, 2024

Language: Английский

Citations

9
MiR-378a-3p/ SLC7A11 regulate ferroptosis in nerve injury induced by lead exposure DOI Creative Commons
Weixuan Wang,

Fan Shi,

Jianmei Cui

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 239, P. 113639 - 113639

Published: May 16, 2022

An increasing number of studies have clarified that ferroptosis plays a vital role in neurodegenerative diseases, which is characterized by the accumulation Fe2+, lipid peroxidation, and alteration mitochondrial structure. However, whether involved nerve injury caused lead exposure remains unclear. In this study, HT22 cells mice were treated with acetate to investigate neurotoxicity. The results showed resulted an increase malondialdehyde (MDA) levels, decrease glutathione (GSH) levels vivo vitro. reactive oxygen species (ROS) expression 4HNE, as well change morphology, also observed acetate. addition, deferoxamine (DFO; iron chelator) attenuated Fe2+ significantly enhanced viability exposed lead. Fer-1 (an anti-ferroptosis agent) reduced level ROS 4HNE lead-treated cells. Furthermore, sharply downregulated SLC7A11 Overexpression reversed changes MDA GSH cell induced exposure. contrast, lower accelerated these parameters. Consequently, we screened miRNAs regulate using TargetScan. We found miR-378a-3p highest among target regulating expression. Inhibition reduction Taken together, findings indicate can cause exerted important effect Our provide new insights into mechanisms underlying effects

Language: Английский

Citations

31
Combined exposure of heat stress and ozone enhanced cognitive impairment via neuroinflammation and blood brain barrier disruption in male rats DOI Creative Commons
Zhen Yan, Yumei Liu, Weidong Wu

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 857, P. 159599 - 159599

Published: Oct. 21, 2022

Heat stress (HS) exposure has been linked to cognitive dysfunction. In reality, high temperature does not occur alone in environment, and ozone (O3) heatwaves usually co-exist atmospheric environment. However, whether O3 exacerbates HS-induced impairment the potential underlying mechanisms have explored experimentally. The aim of this study was determine co-effects HS on dysfunction.48 Sprague Dawley male rats were randomly divided into 4 groups: control, HS, plus (HO3) groups. Rats HO3 group exposed 40 °C every morning from 9:00 12:00 for 15 consecutive days. While groups 0.7 ppm same day 14:00 17:00 Cognitive performance examined with Morris water maze test. Neurodegeneration, glial activation, neuroinflammation, blood brain barrier (BBB) disruption apoptosis evaluated by Western blot, Elisa, immunohistochemistry immunofluorescence staining.HS induced decline neuronal damage rats. Further studies showed that could also induce neuroinflammation hippocampus, decrease expressions ZO-1, claudin-5 occluding, indicative BBB disruption. Impressively, effects as depicted above, be worsened co-exposure rats.Co-exposure promotes possibly through glial-mediated

Language: Английский

Citations

31
Nanomaterials for Fluorescence and Multimodal Bioimaging DOI
Jeladhara Sobhanan, Abdulaziz Anas, Vasudevanpillai Biju

et al.

The Chemical Record, Journal Year: 2023, Volume and Issue: 23(3)

Published: Feb. 15, 2023

Abstract Bioconjugated nanomaterials replace molecular probes in bioanalysis and bioimaging vitro vivo . Nanoparticles of silica, metals, semiconductors, polymers, supramolecular systems, conjugated with contrast agents drugs for image‐guided (MRI, fluorescence, PET, Raman, SPECT, photodynamic, photothermal, photoacoustic) therapy infiltrate into preclinical clinical settings. Small bioactive molecules like peptides, proteins, or DNA to the surfaces help us interface them cells tissues. Nevertheless, toxicity pharmacokinetics nanodrugs, nanoprobes, their components become barriers, underscoring significance developing biocompatible next‐generation agents. This account provides state‐of‐the‐art advancements preparation biological applications bioconjugated molecular, cell, applications. It focuses on preparation, bioimaging, bioanalytical monomodal multimodal nanoprobes composed quantum dots, clusters, iron oxide nanoparticles, a few rare earth metal ion complexes.

Language: Английский

Citations

21
Particulate matter induces depression-like behavior through systemic inflammation and brain-derived neurotrophic factors DOI Creative Commons
Hui Li, Xiaoyu Guo, Pengxiang Li

et al.

Environment International, Journal Year: 2024, Volume and Issue: 194, P. 108883 - 108883

Published: July 20, 2024

Particulate matter (PM) has always received widespread attention, PM2.5 pollution is associated with many adverse effects, including cardiovascular, respiratory and metabolic diseases mood disorders. However, the underlying mechanisms are not yet clear. In this study, small animal whole body inhalation exposure system collected real-time in real environment, which can truly reflect presence status of atmospheric environment. This study investigated depressive like behavior mice exposed to for a long time proved its molecular mechanism through RNA-seq. C57BL/6 male were ambient air together control mice, who breathed filtered high-efficiency particulate filters. Depression was observed PM 4, 6, 8 weeks behavioral experiments, EEG signals, pathological sections. RNA-seq results indicated that might be related pro-inflammatory anti-inflammatory cytokines, as well BDNF pathways hippocampus olfactory bulb. suggests may induce depression MAPK/CREB/BDNF pathway. Atmospheric been classified Class 1 pollutant by International Agency Research on Cancer. Current research mainly believed seriously affected lung health, but there little effects other organs. With improvement quality life, people paying more attention mental while brain. simulated environment explored brain provided solid scientific basis inducing after exposure.

Language: Английский

Citations

4
Effects of Sub-chronic Lead Exposure on Essential Element Levels in Mice DOI
Shaojun Li, Chun Yang, Yi Xiang

et al.

Biological Trace Element Research, Journal Year: 2022, Volume and Issue: 201(1), P. 282 - 293

Published: Feb. 8, 2022

Language: Английский

Citations

18