Maternal exposure to polystyrene nanoparticles retarded fetal growth and triggered metabolic disorders of placenta and fetus in mice

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 854, P. 158666 - 158666

Published: Sept. 13, 2022

Language: Английский

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Dose-effect of polystyrene microplastics on digestive toxicity in chickens (Gallus gallus): Multi-omics reveals critical role of gut-liver axis

Journal of Advanced Research, Journal Year: 2022, Volume and Issue: 52, P. 3 - 18

Published: Nov. 10, 2022

Microplastic pollution seriously threatens the health and safety of humans wildlife. Avian is one main species endangered by microplastics. However, damage mechanism microplastics to digestive system avian not clear. The gut-liver axis a bidirectional channel that regulates exchange information between gut liver also key target for tissue caused pollutants. This study aimed elucidate toxicity in role it. We constructed an exposure model environmental concentrations toxicological chickens reveal polystyrene (PS-MPs) 16S rRNA, transcriptomics metabolomics. PS-MPs changed death mode from apoptosis necrosis pyroptosis upregulating Caspase 8, disrupting intestinal vascular barrier, disturbing flora promoting accumulation lipopolysaccharide. Harmful metabolites were translocated through liver-gut axis, eliciting hepatic immune responses lipid metabolism disorders apoptosis. Liver injury involves multiple molecular effects mitochondrial dynamics disturbance, oxidative stress, endoplasmic reticulum cell cycle disturbance. Furthermore, metabolomics suggested caffeine melanin may be potential natural resistance substances Taken together, our data demonstrate avian, revealing critical will provide reference protecting populations.

Language: Английский

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Oral exposure to polyethylene microplastics alters gut morphology, immune response, and microbiota composition in mice

Environmental Research, Journal Year: 2022, Volume and Issue: 212, P. 113230 - 113230

Published: April 7, 2022

Language: Английский

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Toxic effects of microplastic (Polyethylene) on fish: Accumulation, hematological parameters and antioxidant responses in Korean Bullhead, Pseudobagrus fulvidraco

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 877, P. 162874 - 162874

Published: March 16, 2023

Language: Английский

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Micropollutants characteristics, fate, and sustainable removal technologies for landfill leachate: A technical perspective

Journal of Water Process Engineering, Journal Year: 2023, Volume and Issue: 53, P. 103649 - 103649

Published: March 15, 2023

Language: Английский

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Evodiamine alleviates DEHP-induced hepatocyte pyroptosis, necroptosis and immunosuppression in grass carp through ROS-regulated TLR4 / MyD88 / NF-κB pathway

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 140, P. 108995 - 108995

Published: Aug. 11, 2023

Language: Английский

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Selenoprotein K protects skeletal muscle from damage and is required for satellite cells-mediated myogenic differentiation

Redox Biology, Journal Year: 2022, Volume and Issue: 50, P. 102255 - 102255

Published: Feb. 4, 2022

The regeneration of adult skeletal muscle after injury is primarily initiated by satellite cells (SCs), but the regulatory mechanisms committed to myogenic differentiation remain poorly explored. Small molecular selenoprotein K (SelK) plays crucial roles in modulation endoplasmic reticulum (ER) stress and against oxidative stress. Here, we first showed that SelK expression activated during both vivo vitro. Meanwhile, loss delayed regeneration, inhibited development myoblasts into myotubes, was accompanied reduced factors (MRFs). Moreover, ER stress, intracellular reactive oxygen species (ROS), autophagy apoptosis under myogenesis induction were more severe SelK-deficient mice than corresponding control groups. Supplementation with specific inhibitors alleviate excessive or partly rescued potential formation myotubes. Notably, demonstrated Self-mediated regulation cellular redox status derived from its subsequent effects on Together, our results suggest protects damage a regulator myogenesis.

Language: Английский

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Polystyrene microplastics induce apoptosis and necroptosis in swine testis cells via ROS/MAPK/HIF1α pathway

Environmental Toxicology, Journal Year: 2022, Volume and Issue: 37(10), P. 2483 - 2492

Published: July 6, 2022

Microplastics (MPs) generally refer to the plastic fragments or particles smaller than 5 mm in diameter, which are closely concerned due their widespread presence environment. Recent studies have shown that MPs a serious threat on reproductive health of organisms. Pigs often selected as model animals because high similarity human tissues and organs. However, there no reports effects mechanisms exposure swine germ cells. In present study, we established testis (ST) cell models exposed 250, 500, 1000 μg/ml polystyrene microplastics (PS-MPs, 1-10 μm), respectively. The findings revealed PS-MPs reduced viability dose-dependently. Acridine orange/ethidium bromide staining flow cytometry results indicated occurrence apoptosis necrosis ST cells under exposure, expression changes relevant marker genes (B-cell lymphoma-2, Bcl-2 Associated X, Caspase-3, Caspase-9, Receptor-interacting protein kinase 1, 3, Mixed lineage domain-like, Caspase-8) were clarified via quantitative real-time PCR western blot. Further mechanistic found treatment induced excessive intracellular reactive oxygen species (ROS) production, promoted phosphorylation mitogen-activated (MAPK) pathway-related (P38, c-Jun N-terminal kinase, extracellular regulated kinases) activated downstream gene hypoxia-inducible factor (HIF1α). conclusion, our study suggests causes necroptosis ROS/MAPK/HIF1α signaling pathway.

Language: Английский

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Combined negative effects of microplastics and plasticizer DEHP: The increased release of Nets delays wound healing in mice

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 862, P. 160861 - 160861

Published: Dec. 14, 2022

Language: Английский

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Pristine and artificially-aged polystyrene microplastic particles differ in regard to cellular response

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 435, P. 128955 - 128955

Published: April 19, 2022

Language: Английский

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