Small molecule metabolites: discovery of biomarkers and therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 20, 2023

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks diseases. Metabolite signatures that have close proximity subject's phenotypic informative dimension, are useful for predicting diagnosis prognosis diseases as well monitoring treatments. The lack early biomarkers could poor serious outcomes. Therefore, noninvasive methods with high specificity selectivity desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool biomarker pathway analysis, revealing possible mechanisms human various deciphering therapeutic potentials. It help identify functional related variation delineate biochemical changes indicators pathological damage prior disease development. Recently, scientists established large number profiles reveal underlying networks target exploration in biomedicine. This review summarized analysis on potential value small-molecule candidate metabolites clinical events, may better diagnosis, prognosis, drug screening treatment. We also discuss challenges need be addressed fuel next wave breakthroughs.

Language: Английский

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The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective

Nanoscale Advances, Journal Year: 2023, Volume and Issue: 5(10), P. 2674 - 2723

Published: Jan. 1, 2023

The interaction of nanoparticles (NPs) with cells depends on their physicochemical properties and can lead to cytotoxic events. Metabolomics reveals the molecular mechanisms this nanotoxicity avoids misleading interferences NPs.

Language: Английский

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Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress

Redox Biology, Journal Year: 2022, Volume and Issue: 59, P. 102569 - 102569

Published: Dec. 5, 2022

The metabolic associated fatty liver disease (MAFLD) is a public health challenge, leading to global increase in chronic disease. respiratory exposure of silica nanoparticles (SiNPs) has revealed induce hepatotoxicity. However, its role the pathogenesis and progression MAFLD was severely under-studied. In this context, hepatic impacts SiNPs were investigated vivo vitro through using ApoE-/- mice free acid (FFA)-treated L02 hepatocytes. Histopathological examinations biochemical analysis showed via intratracheal instillation aggravated steatosis, lipid vacuolation, inflammatory infiltration even collagen deposition mice, companied with increased ALT, AST LDH levels. enhanced synthesis inhibited β-oxidation efflux may account for TC/TG by SiNPs. Consistently, induced elevated TC FFA-treated cells. Further, activation oxidative stress detected vitro, as evidenced ROS accumulation, MDA, declined GSH/GSSG down-regulated Nrf2 signaling. Endoplasmic reticulum (ER) also triggered response SiNPs-induced reflecting remarkable ER expansion BIP expression. More importantly, an UPLC-MS-based metabolomics that disturbed profile prominently on amino acids metabolisms. particular, identified differential metabolites strongly correlated ensuing accumulation injuries, contributing diseases. Taken together, our study promoted steatosis damage, resulting aggravation progression. metabolisms-mediated key contributor phenomenon from perspective.

Language: Английский

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Omics approaches for the assessment of biological responses to nanoparticles

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 114992 - 114992

Published: July 5, 2023

Language: Английский

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Label-free MIP-SERS biosensor for sensitive detection of colorectal cancer biomarker

Talanta, Journal Year: 2023, Volume and Issue: 258, P. 124461 - 124461

Published: March 21, 2023

Language: Английский

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Prospects and hazards of silica nanoparticles: Biological impacts and implicated mechanisms

Biotechnology Advances, Journal Year: 2023, Volume and Issue: 69, P. 108277 - 108277

Published: Nov. 3, 2023

Language: Английский

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Molecular mechanism of nanomaterials induced liver injury: A review

World Journal of Hepatology, Journal Year: 2024, Volume and Issue: 16(4), P. 566 - 600

Published: April 24, 2024

The unique physicochemical properties inherent to nanoscale materials have unveiled numerous potential applications, spanning beyond the pharmaceutical and medical sectors into various consumer industries like food cosmetics. Consequently, humans encounter nanomaterials through diverse exposure routes, giving rise health considerations. Noteworthy among these are silica specific metallic nanoparticles, extensively utilized in products, which garnered substantial attention due their propensity accumulate induce adverse effects liver. This review paper aims provide an exhaustive examination of molecular mechanisms underpinning nanomaterial-induced hepatotoxicity, drawing insights from both vitro vivo studies. Primarily, most frequently observed manifestations toxicity following cells or animal models involve initiation oxidative stress inflammation. Additionally, we delve existing employed for evaluating hepatotoxic nanomaterials, emphasizing persistent endeavors advance bolster reliability nanotoxicology research.

Language: Английский

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Pollutants in Microenvironmental Cellular Interactions During Liver Inflammation Cancer Transition and the Application of Multi-Omics Analysis

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 163 - 163

Published: Feb. 25, 2025

This study categorizes pollutant-induced inflammation–cancer transition into three stages: non-alcoholic fatty liver disease (NAFLD), fibrosis, and hepatocellular carcinoma (HCC). It systematically reveals the temporal heterogeneity of damage. The findings indicate that pollutants not only directly damage hepatocytes but also modulate key cells in immune microenvironment, such as hepatic stellate (HSCs) Kupffer cells, thereby amplifying inflammatory fibrotic responses, ultimately accelerating progression HCC. Mechanistically, early stage primarily cause hepatocyte injury through oxidative stress lipid metabolism dysregulation. During fibrosis stage, promote by inducing extracellular matrix accumulation, while HCC they drive tumorigenesis via activation Wnt/β-catenin pathway p53 inactivation. Through multi-omics analyses, this identifies critical pathogenic molecules signaling pathways regulated pollutants, providing new insights their mechanisms, potential biomarkers, therapeutic targets. These offer valuable guidance for development diagnostic strategies diseases formulation environmental health risk prevention measures.

Language: Английский

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Assessing inorganic nanoparticle toxicity through omics approaches

Nanoscale, Journal Year: 2024, Volume and Issue: 16(34), P. 15928 - 15945

Published: Jan. 1, 2024

This review aims to provide a deeper understanding and new perspectives of omics approaches characterize the toxicity biological interactions inorganic nanoparticles, improve safety nanoparticle applications.

Language: Английский

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Multi-omics Integration Analysis: Tools and Applications in Environmental Toxicology

Environmental Pollution, Journal Year: 2024, Volume and Issue: 360, P. 124675 - 124675

Published: Aug. 3, 2024

Language: Английский

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