Investigation of nephrotoxicity on mice exposed to polystyrene nanoplastics and the potential amelioration effects of DHA-enriched phosphatidylserine

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 892, P. 164808 - 164808

Published: June 10, 2023

Language: Английский

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Features, Potential Invasion Pathways, and Reproductive Health Risks of Microplastics Detected in Human Uterus

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(24), P. 10482 - 10493

Published: June 3, 2024

Microplastics (MPs) are ubiquitous in global ecosystems and may pose a potential risk to human health. However, critical information on MP exposure female reproductive health is still lacking. In this study, we characterized MPs endometrium investigated their size-dependent entry mode as well toxicity. Endometrial tissues of 22 patients were examined, revealing that was contaminated with MPs, mainly polyamide (PA), polyurethane (PU), polyethylene terephthalate (PET), polypropylene (PP), polystyrene (PS), (PE), ranging from 2–200 μm size. Experiments conducted mice demonstrated the invasion uterus by modulated either through diet–blood circulation (micrometer-sized particles) or via vagina–uterine lacuna (larger particles reaching size 100 μm. Intravenous resulted reduced fertility abnormal sex ratio mouse offspring (P < 0.05). After 3.5 months intragastric exposure, there significant inflammatory response 0.05), confirmed embryo transfer uterine factor leading decreased fertility. Furthermore, endometrial organoids cultured vitro exhibited significantly apoptotic responses disrupted growth patterns 0.01). These findings raise concerns regarding contamination its effects

Language: Английский

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Exposure to different surface-modified polystyrene nanoparticles caused anxiety, depression, and social deficit in mice via damaging mitochondria in neurons

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 919, P. 170739 - 170739

Published: Feb. 9, 2024

Language: Английский

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The hidden threat: Unraveling the impact of microplastics on reproductive health

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 935, P. 173177 - 173177

Published: May 13, 2024

Language: Английский

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Comparing the effects and mechanisms of exposure to polystyrene nanoplastics with different functional groups on the male reproductive system

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 922, P. 171299 - 171299

Published: Feb. 27, 2024

Language: Английский

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The micro(nano)plastics perspective: exploring cancer development and therapy

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Language: Английский

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Adverse effects of microplastics and nanoplastics on the reproductive system: A comprehensive review of fertility and potential harmful interactions

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 903, P. 166258 - 166258

Published: Aug. 12, 2023

In recent years, microplastics (MPs) and nanoplastics (NPs) have caused ubiquitous environmental pollution raised widespread concern about their potential toxicity to human health, especially in the reproductive system. Moreover, infertility affects >15 % of couples worldwide, birth rate is decreasing. Environmental factors are some most important causes infertility. However, little known effects MPs NPs on testes ovaries. These particles can enter body primarily via ingestion, inhalation, skin contact, target system a size-dependent manner disturb germ cell other somatic development. Our study systematically reviewed adverse plastic function offers valuable insights into different stages cells mechanisms. synergistic these carried contaminants was summarized. Given limited research scale, shift toward innovative technologies adoption multiple omics recommended for advancing related studies. Further needed explore based size, polymer type, shape, toxins, establish effective protective measures, develop precision medicine targeted damage.

Language: Английский

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Size-dependent toxicity of polystyrene microplastics on the gastrointestinal tract: Oxidative stress related-DNA damage and potential carcinogenicity

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 169514 - 169514

Published: Dec. 20, 2023

Language: Английский

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Combined Effects of Polystyrene Nanosphere and Homosolate Exposures on Estrogenic End Points in MCF-7 Cells and Zebrafish

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(2)

Published: Feb. 1, 2024

Micro- and nanoplastics (MNPs) homosalate (HMS) are ubiquitous emerging environmental contaminants detected in human samples. Despite the well-established endocrine-disrupting effects (EDEs) of HMS, interaction between MNPs HMS its impact on HMS-induced EDEs remain unclear.

Language: Английский

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Lactating exposure to microplastics at the dose of infants ingested during artificial feeding induced reproductive toxicity in female mice and their offspring

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 174972 - 174972

Published: July 23, 2024

Language: Английский

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