Gondwana Research, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Environment International, Journal Year: 2025, Volume and Issue: 196, P. 109316 - 109316
Published: Feb. 1, 2025
Although microplastics have been detected in human blood, placenta and other tissues. In this study, for the first time, we characterized presence variation of microplastic deposition patterns three skeletal tissues, namely bone, cartilage, intervertebral discs. Forty fragments were observed 24 samples from disc, ranging 25.44 to 407.39 μm diameter. The abundance disc (61.1 ± 44.2 particles/g) was higher than those bone (22.9 15.7 cartilage tissue (26.4 17.6 particles/g). average sizes discs (159.5 103.8 μm) (138.86 105.67 larger that (87.5 30.7 μm). most frequently identified polymers polypropylene (35 %), ethylene vinyl acetate copolymer (30 polystyrene (20 %). vivo experiment suggested invaded through blood circulation after 4 weeks exposure. Serum levels tumor necrosis factor-α (TNF-α), Type Ⅰ procollagen amino-terminal peptide (PINP), tartrate-resistant acid phosphatase-5b (TRACP-5b) elevated compared with control group (p < 0.05). Our study suggests invade supply, causing distinct accumulation these regions. Microplastic invasion can affect health by influencing expression inflammatory morphogenetic cytokines. These findings provide insights into investigating impact on health.
Language: Английский
Citations
5
Deleted Journal, Journal Year: 2025, Volume and Issue: 7(1)
Published: Jan. 11, 2025
As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.
Language: Английский
Citations
2
Environmental Pollution, Journal Year: 2025, Volume and Issue: 369, P. 125850 - 125850
Published: Feb. 14, 2025
Language: Английский
Citations
2
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 467, P. 133714 - 133714
Published: Feb. 5, 2024
Language: Английский
Citations
17
Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(5), P. 4186 - 4202
Published: April 30, 2024
As environmental plastic waste degrades, it creates an abundance of diverse microplastic particles. Consequently, microplastics contaminate drinking water and many staple food products, meaning the oral ingestion is important exposure route for human population. Microplastics have long been considered inert, however their ability to promote microbial dysbiosis as well gut inflammation dysfunction suggests they are more noxious than first thought. More alarmingly, there evidence permeating from throughout body, with adverse effects on immune nervous systems. Coupled now-accepted role gut-brain axis in neurodegeneration, these findings support hypothesis that this ubiquitous pollutant contributing rising incidence neurodegenerative diseases, like Alzheimer’s disease Parkinson’s disease. This comprehensive narrative review explores consequences gut-brain-axis by considering current gastrointestinal uptake disruption, activation, translocation neurological effects. now a permanent feature global environment, understanding gut, brain, whole body will facilitate critical further research inform policy changes aimed at reducing any consequences.
Language: Английский
Citations
16
Kidney International, Journal Year: 2024, Volume and Issue: 106(3), P. 400 - 407
Published: June 18, 2024
Language: Английский
Citations
12
Advanced Science, Journal Year: 2024, Volume and Issue: 11(28)
Published: May 15, 2024
Biodegradable plastics, hailed for their environmental friendliness, may pose unforeseen risks as they undergo gastrointestinal degradation, forming oligomer nanoplastics. Despite this, the influence of degradation on potential human toxicity biodegradable plastics remains poorly understood. To this end, impact murine in vivo digestive system is investigated biotransformation, biodistribution, and PLA polymer MPs. Through a 28-day repeated oral gavage study mice, it revealed that microplastics incomplete complete respectively, tract. Incompletely degraded transform into nanoplastics, heightening bioavailability toxicity, thereby exacerbating overall toxic effects. Conversely, reduces mitigates offering avenue reduction. Additionally, illuminates shared targets mechanisms Parkinson's disease-like neurotoxicity induced by both microplastics. This involves upregulation MICU3 midbrains, leading to neuronal mitochondrial calcium overload. Notably, mitigated inhibiting influx with MCU-i4 or facilitating efflux DBcAMP mice. These findings enhance understanding toxicological implications health.
Language: Английский
Citations
10
Toxicology and Environmental Health Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Language: Английский
Citations
1
Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137596 - 137596
Published: Feb. 12, 2025
Language: Английский
Citations
1
Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118056 - 118056
Published: March 19, 2025
Language: Английский
Citations
1