Bisphenol A Regulates the TNFR1 Pathway and Excessive ROS Mediated by miR-26a-5p/ADAM17 Axis to Aggravate Selenium Deficiency-Induced Necroptosis in Broiler Veins DOI

Xue Fan,

Yixuan Wang, Jintao Zhang

et al.

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(4), P. 1722 - 1740

Published: July 8, 2023

Language: Английский

GPX4 in cell death, autophagy, and disease DOI Creative Commons
Yangchun Xie, Rui Kang, Daniel J. Klionsky

et al.

Autophagy, Journal Year: 2023, Volume and Issue: 19(10), P. 2621 - 2638

Published: June 4, 2023

Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX (phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in use of a reducing agent scavenging lipid peroxidation products. There are three isoforms: cytosolic (cGPX4), mitochondrial (mGPX4), and nuclear (nGPX4), with distinct spatiotemporal expression patterns during embryonic development adult life. In addition to inducing phenotype ferroptosis, loss can some cells trigger apoptosis, necroptosis, pyroptosis, or parthanatos, which mediates accelerates developmental defects, tissue damage, sterile inflammation. The interaction autophagic degradation pathway further modulates cell fate response oxidative stress. Impaired function implicated tumorigenesis, neurodegeneration, infertility, inflammation, immune disorders, ischemia-reperfusion injury. Additionally, R152H mutation promote Sedaghatian-type spinal metaphyseal dysplasia, rare fatal disease newborns. Here, we discuss roles classical functions well emerging GPX4-regulated processes death, autophagy, disease.Abbreviations: AA: arachidonic acid; cGPX4: GPX4; CMA: chaperone-mediated autophagy; DAMPs: danger/damage-associated molecular patterns; mGPX4: nGPX4: GSDMD-N: N-terminal fragment GSDMD; I/R: ischemia-reperfusion; PLOOH: phospholipid hydroperoxide; PUFAs: polyunsaturated fatty acids; RCD: regulated death; ROS: reactive oxygen species; Se: selenium; SSMD: spondylometaphyseal dysplasia; UPS: ubiquitin-proteasome system

Language: Английский

Citations

248
Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-κB-NLRP3-GSDMD and AMPK-PGC-1α axes DOI
Yue Zhang,

Kai Yin,

Dongxu Wang

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 840, P. 156727 - 156727

Published: June 14, 2022

Language: Английский

Citations

174
Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice DOI
Hao Wu,

Tong Xu,

Ting Chen

et al.

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 838, P. 155825 - 155825

Published: May 19, 2022

Language: Английский

Citations

123
Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications DOI Creative Commons
Yongxin Zheng, Junlu Sun,

Zhiting Luo

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(11)

Published: Nov. 26, 2024

Abstract Regulated cell death (RCD) refers to the form of that can be regulated by various biomacromolecules. Each modalities have their distinct morphological changes and molecular mechanisms. However, intense evidences suggest lipid peroxidation common feature initiates propagates death. Excessive alters property membrane further damage proteins nucleic acids, which is implicated in human pathologies. Here, we firstly review classical chain process peroxidation, clarify current understanding myriad roles mechanisms RCD types. We also discuss how involves diseases such intimate association between peroxidation-driven leveraged develop rational therapeutic strategies.

Language: Английский

Citations

18
Polystyrene nanoparticle exposure supports ROS-NLRP3 axis-dependent DNA-NET to promote liver inflammation DOI
Qianru Chi, Tongwen Xu,

Yujiao He

et al.

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 439, P. 129502 - 129502

Published: July 3, 2022

Language: Английский

Citations

59
Di-(2-ethyl hexyl) phthalate induced oxidative stress promotes microplastics mediated apoptosis and necroptosis in mice skeletal muscle by inhibiting PI3K/AKT/mTOR pathway DOI
Xiaojing Liu, Yilei Zhang, Xinyue Sun

et al.

Toxicology, Journal Year: 2022, Volume and Issue: 474, P. 153226 - 153226

Published: May 1, 2022

Language: Английский

Citations

40
ROS mediated pyroptosis-M1 polarization crosstalk participates in inflammation of chicken liver induced by bisphenol A and selenium deficiency DOI
Xu Shi,

Tong Xu,

Xiaojing Li

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 324, P. 121392 - 121392

Published: March 9, 2023

Language: Английский

Citations

29
Di (2-ethylhexyl) phthalate and polystyrene microplastics co-exposure caused oxidative stress to activate NF-κB/NLRP3 pathway aggravated pyroptosis and inflammation in mouse kidney DOI
Shanshan Li,

Xuedie Gu,

Muyue Zhang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 926, P. 171817 - 171817

Published: March 19, 2024

Language: Английский

Citations

14
Different types of cell death and their interactions in myocardial ischemia–reperfusion injury DOI Creative Commons

Bingxin Du,

Qiang Fu, Qin Yang

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 5, 2025

Myocardial ischemia-reperfusion (I/R) injury is a multifaceted process observed in patients with coronary artery disease when blood flow restored to the heart tissue following ischemia-induced damage. Cardiomyocyte cell death, particularly through apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis, pivotal myocardial I/R injury. Preventing death during of vital for improving ischemic cardiomyopathy. These multiple forms can occur simultaneously, interact each other, contribute complexity In this review, we aim provide comprehensive summary key molecular mechanisms regulatory patterns involved these five types We will also discuss crosstalk intricate interactions among mechanisms, highlighting interplay between different death. Furthermore, explore specific molecules or targets that participate pathways elucidate their action. It important note manipulating distinct processes may have significant impact on reducing By enhancing researchers' understanding injury, review aims pave way development novel interventions cardio-protection affected by

Language: Английский

Citations

2
Pyroptosis and Intervertebral Disc Degeneration: Mechanistic Insights and Therapeutic Implications DOI Creative Commons
Yuying Ge, Yuying Chen,

Chijiao Guo

et al.

Journal of Inflammation Research, Journal Year: 2022, Volume and Issue: Volume 15, P. 5857 - 5871

Published: Oct. 1, 2022

Abstract: Low back pain (LBP) is a common problem worldwide, resulting in great patient suffering and challenges for the social health system. Intervertebral disc (IVD) degeneration (IVDD) widely acknowledged as one of key causes LBP. Accumulating evidence suggests that aberrant pyroptosis IVD cells involved pathogenesis IVDD progression, however, comprehensive roles have not been fully established, leaving attempts to treat with anti-pyroptosis approaches questionable. In this review, we summarize characteristics emphasize effects cell on pathological progression IVDD, including secretion cytokines, nucleus pulposus apoptosis autophagy, accelerated extracellular matrix degradation, annulus fibrosus rupture, cartilage endplate calcification, vascularization, sensory sympathetic fiber neoinnervation, infiltrating lymphatic vessels. Finally, discuss several interventions used by targeting pyroptosis. This review provides novel insights into crucial role pathogenesis, could be informative developing therapeutic Keywords: low pain, intervertebral degeneration, pyroptosis, inflammasome, anti-pyroptotic approach

Language: Английский

Citations

33