Evaluating the Therapeutic Potential of Amygdalin: Cytotoxic and Antimicrobial Properties

Tissue and Cell, Journal Year: 2024, Volume and Issue: 89, P. 102443 - 102443

Published: June 12, 2024

Language: Английский

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Anticancer Attributes and Multifaceted Pharmacological Implications of Laetrile and Amygdalin

Cell Biology International, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

ABSTRACT Laetrile, known as vitamin B17, is often used interchangeably with amygdalin. Laetrile a semi‐synthesis product of amygdalin, whereas amygdalin naturally occurring substance in many plants. Both compounds have nitrile functional group that, when activated by the intestinal enzyme β‐glucosidases, releases hydrogen cyanide. The two been considered for long time alternative therapy cancer treatment however, findings available literature are discordant on real efficacy laetrile/amygdalin cancer, highlighting negative benefit‐risk ratio. In this regard, study aimed to comprehensively analyze scientific data laetrile/amygdalin, special emphasis their pharmacokinetics, underlying pharmacological properties, mode action potent antitumor agent, and effect human health. results showed that there no clear evidence following administration, especially at clinical trial level. However, vitro studies biological activity these positive effects related antifibrotic, anti‐inflammatory, antiasthmatic, immunoregulatory processes. Laetrile's mechanism closely resembles affecting signaling pathways. due its cyanide toxicity, it was banned food drug administration (FDA) safety concerns. Despite not receiving permission from FDA, laetrile emerged an 1970s. Nonetheless, continuing research investigating safer methods activating targeted treatment. This opens interesting prospects using medical therapies, which, further needed.

Language: Английский

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Amygdalin as a Promising Anticancer Agent: Molecular Mechanisms and Future Perspectives for the Development of New Nanoformulations for Its Delivery

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 14270 - 14270

Published: Sept. 19, 2023

Cancer rates are increasing, and cancer is one of the main causes death worldwide. Amygdalin, also known as vitamin B17 (and laetrile, a synthetic compound), cyanogenic glycoside compound that mainly found in kernels pulps fruits. This has been proposed for decades promising naturally occurring substance which may provide anticancer effects. comprehensive review critically summarizes scrutinizes available studies exploring effect amygdalin, highlighting its potential molecular mechanisms well need nontoxic formulation this substance. In-depth research was performed using most accurate scientific databases, e.g., PubMed, Cochrane, Embase, Medline, Scopus, Web Science, applying effective, characteristic, relevant keywords. There several pieces evidence to support idea amygdalin can exert effects against lung, breast, prostate, colorectal, cervical, gastrointestinal cancers. Amygdalin reported induce apoptosis cells, inhibiting cells’ proliferation slowing down tumor metastatic spread. However, only few have vivo animal models, while clinical remain even more scarce. The current cannot recommendation use nutritional supplements with due cyano-moiety exerts adverse side Preliminary data shown nanoparticles be alternative enhance simultaneously reducing seems agent disease development progression. there strong demand human explore prevention and/or treatment efficiency cancer. Moreover, could used lead by effectively recent developments drug discovery processes.

Language: Английский

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Comparison of the Antibacterial Activity of Panax Ginseng and Symphytum Officinale with Metronidazole against P. gingivalis: An MIC and MBC Analysis

The Open Dentistry Journal, Journal Year: 2024, Volume and Issue: 18(1)

Published: May 7, 2024

Background The RapID ANA II panel was used to evaluate bacterial responses, and the minimum inhibitory concentration (MIC) bactericidal (MBC) were established. Aim This study aimed investigate antibacterial effects of Metronidazole, Symphytum Officinale, Panax Ginseng on P. gingivalis Materials Methods strains, including strain ATCC 33277 an isolate, selected prepared. A variety test compounds, Officinale , Ginseng, procured manufactured. consistent technique determine MIC MBC. We assess responses. Additionally, a suitable software conduct statistical analysis. Results findings from MBC tests showed notable variations noticeable impact combination therapy (G+F S+F) in comparison individual drugs alone. Lower values seen when Metronidazole (G+F) (S+F) combined, demonstrating synergistic effect (p < 0.01). Positive results found for ρ-Nitrophenyl-β, D-disaccharide (BLTS), σ-Nitrophenyl-β, D-galactoside (ONPG), ρ-Nitrophenyl-n-acetyl-β, D glucosaminide (NAG), ρ-Nitrophenylphosphate (PO4), Phenylalanine-β-naphthylamide (PAL), Pyrrolidonyl-β-naphthylamide (PYR), Tryptophane (IND) panel, whereas negative obtained Urea (URE), ρ-Nitrophenyl-α, L-arabinoside (aARA), D-glucoside (aGLU), (BGLU), (aGAL), L-fucoside (aFUC), Proline-β-naphthylamide (PRO), Serine-β-naphthylamide (SER). Conclusion Our shows that therapies using Officnale with have increased efficacy against . These point possibility these herbal remedies complementing conventional medicine. In this study, helped identify characterise by offering useful insights into reactions. Nonetheless, it is necessary more studies examine therapeutic uses alternative infection treatments.

Language: Английский

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Assessing Therapeutic Value and Side Effects of Key Botanical Compounds for Optimized Medical Treatments

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Abstract Due to the significance of variable chemical groups across a wide spectrum modern medicine, it is imperative determine what most widely used group in medical applications with fewest side effects. Ten compounds from ten that are commonly known for their uses were compared terms therapeutic potential and The comparison among selected indicated superiority flavonoids over other multitude utilizations lower Kaempferol quercetin showed higher utilization Whereas alkaloid lowest levels use highest Based on conducted, concluded give priority flavonoid being because they exhibit Within flavonoids, kaempferol two highly recommended be widest range applications. Serious caution should considered before applying alkaloids any service. Understanding characteristics these can aid developing safer more effective treatments medicinal plants.

Language: Английский

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Metronidazole Potentiation by Panax Ginseng and Symphytum officinale: A New Strategy for P. gingivalis Infection Control

Antibiotics, Journal Year: 2023, Volume and Issue: 12(8), P. 1288 - 1288

Published: Aug. 4, 2023

The important periodontal disease pathogen Porphyromonas gingivalis produces thick biofilms that increase its pathogenicity. Finding natural antimicrobial agents is crucial because of the rise in antibiotic resistance. purpose this study was to determine if plant extracts such as Symphytum officinale (S) and Panax Ginseng (G) were effective against P. separately combination with a common antibiotic, metronidazole (F). Six different dilutions produced using concentrations antibiotics F, G, S two-fold serial dilution technique. To evaluate effects these substances, biofilm inhibition experiments conducted. Plaque samples collected from periodontitis patients isolate gingivalis, standard strain (ATCC 33277) purchased. Additionally, Acylated Homoserine Lactones (AHLs) detection carried out look for any activity would interfere quorum sensing. GraphPad Prism used statistical analysis p-value < 0.05. combinations (S+F) showed maximum effectiveness (98.7%), which slightly better than G+F (98.2%), substantial variations levels treatment regimes. Notably, patient more active strain. their at particular had notable inhibitory on generation AHL (p 0.05). highlights possibility treatments AHLs, both own metronidazole. These organic substances may open door cutting-edge methods treating disorders.

Language: Английский

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The Cytotoxic Effect of Ciprofloxacin Laetrile Combination on Esophageal Cancer Cell Line

Asian Pacific Journal of Cancer Prevention, Journal Year: 2024, Volume and Issue: 25(4), P. 1433 - 1440

Published: April 1, 2024

Objective: aim of this study was to examine the synergistic effect between antibacterial drug ciprofloxacin and natural compound laetrile on esophageal cancer cells, specifically focusing their combined cytotoxic effect. Methods: The effects two alternative incubation durations (24 72 hours) were studied using an cell line. Ciprofloxacin, laetrile, combinations tested at concentrations ranging from 1 1000 micrograms/milliliter, enhance safety combination, combination constituents reduced by half compared when they are used individually, index then calculated estimate components' possible effects. Result: results indicate that cytotoxicity greater than either or alone, increased with higher longer periods, in other words, pattern time-dependent (cell-cycle specific), concentration dependent, non-specific). Conclusion: found had a inhibitory growth cells alone. This suggests components mixture, which can be attributed complementary mechanism ingredients combination.

Language: Английский

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Research-Gap-Spotting in Plum–Apricot Hybrids—Bioactive Compounds, Antioxidant Activities, and Health Beneficial Properties

Horticulturae, Journal Year: 2023, Volume and Issue: 9(5), P. 584 - 584

Published: May 14, 2023

Plum–apricot hybrids are successful backcrosses of plums and apricots resulting in plumcots, pluots, apriums. A topic search on plums, apricots, plumcots shows that extensive information exists the agro-morphology, genotyping, bioactive substances, nutritive value genus Prunus, particular. However, when results for plum–apricot were evaluated period 2010–2023, only a few papers focused partially their metabolomics. database (Scopus, PubMed, Google Scholar) exposed less than 10 articles/year appeared Scopus hybrids, 618 found Scholar (2010–2023), 2 PubMed same using keywords. This grand research opportunity need providing thorough chemical characterization existing hybrids. review aims at schematizing available about (with reference to parents), identifying gaps compounds, antioxidant activities, health beneficial properties, as well pointing future perspectives terms fruit hybrid characterization.

Language: Английский

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Metronidazole Potentiation by Panax Ginseng and Symphidium Officinale: A New Strategy for P. gingivalis Infection Control

Published: July 10, 2023

Background: The important periodontal disease pathogen Porphyromonas gingivalis produces large biofilms that increase its pathogenicity. Finding natural antimicrobial agents is crucial because of the rise in antibiotic resistance. Objective: purpose this study was to determine if plant extracts such as Symphytum officinale (S) and Panax ginseng (G) were effective against P. separately combination with a common Metronidazole (F). Materials Procedures: Six different dilutions produced G F S using two-fold serial dilution technique. To evaluate effects these substances biofilm inhibition experiments conducted. Plaque samples collected from periodontitis patients isolate standard strain (ATCC 33277) bought. Additionally, Acylated Homoserine Lactones (AHLs) detection carried out look for any activity would interfere quorum sensing. GraphPad prism used statistical analysis p value &amp;lt; 0.05. Results: combinations Officinale (S+F) showed maximum effectiveness (98.7%), which better than G+F (98.2%) substantial variations levels treatment regimes. Notably, patient more active strain. their at particular had notable inhibitory on generation AHL (p &amp;lt;0.05). Conclusion: highlights possibility Ginseng treatments AHLs, both own Metronidazole. These organic may open door cutting-edge methods treating disorders.

Language: Английский

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Electrospun amygdalin and Inula helenium extract-loaded polylactic acid (PLA)/Polyvinylpyrrolidone (PVP) nanofibrous patches for colon cancer treatment: Fabrication, characterization and antitumour effect results

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105940 - 105940

Published: July 4, 2024

Language: Английский

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