Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis

Brain Behavior and Immunity, Journal Year: 2021, Volume and Issue: 101, P. 93 - 135

Published: Dec. 29, 2021

Language: Английский

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Psychiatric and neurological complications of long COVID

Journal of Psychiatric Research, Journal Year: 2022, Volume and Issue: 156, P. 349 - 360

Published: Oct. 20, 2022

Language: Английский

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Post-COVID-19 Syndrome: Involvement and Interactions between Respiratory, Cardiovascular and Nervous Systems

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(3), P. 524 - 524

Published: Jan. 20, 2022

Though the acute effects of SARS-CoV-2 infection have been extensively reported, long-term are less well described. Specifically, while clinicians endure to battle COVID-19, we also need develop broad strategies manage post-COVID-19 symptoms and encourage those affected seek suitable care. This review addresses possible involvement lung, heart brain in post-viral syndromes describes suggested management syndrome. Post-COVID-19 respiratory manifestations comprise coughing shortness breath. Furthermore, arrhythmias, palpitations, hypotension, increased rate, venous thromboembolic diseases, myocarditis failure usual cardiovascular events. Among neurological manifestations, headache, peripheral neuropathy symptoms, memory issues, lack concentration sleep disorders most commonly observed with varying frequencies. Finally, mental health issues affecting abilities mood fluctuations, namely anxiety depression, frequently seen. long COVID is a complex syndrome protracted heterogeneous patients who experience sequelae require personalized treatment as ongoing support.

Language: Английский

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Post-COVID-19 Condition

Annual Review of Medicine, Journal Year: 2022, Volume and Issue: 74(1), P. 55 - 64

Published: Aug. 1, 2022

An estimated 10-15% of those infected with SARS-CoV-2 may have post-COVID-19 condition. Common lingering signs and symptoms include shortness breath, fatigue, high heart rate, memory cognitive dysfunction even several months after infection, often impacting survivors' quality life. The prevalence duration individual remain difficult to ascertain due the lack standardized research methods across various studies limited patient follow-up in clinical studies. Nonetheless, data indicate condition occur independent acuity initial hospitalization status, age, or pre-existing comorbidities. Risk factors female sex underlying respiratory psychiatric disease. Supportive therapies mitigate mainstay treatment. Reassuringly, most patients experience a reduction by 1 year. use universal case definition shared will allow for further clarity regarding pervasiveness this entity its long-term health consequences.

Language: Английский

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Neuropsychiatric aspects of long COVID: A comprehensive review

Psychiatry and Clinical Neurosciences, Journal Year: 2022, Volume and Issue: 77(2), P. 84 - 93

Published: Nov. 17, 2022

Although some patients have persistent symptoms or develop new following coronavirus disease 2019 (COVID-19) infection, neuropsychiatric aspects of long COVID are not well known. This review summarizes and provides an update on the dimensions COVID. Its manifestations commonly include fatigue, cognitive impairment, sleep disorders, depression, anxiety, post-traumatic stress disorder. There no specific tests for COVID, but characteristic findings such as hypometabolism positron emission tomography been reported. The possible mechanisms inflammation, ischemic effects, direct viral invasion, social environmental changes. Some patient characteristics severity complications acute COVID-19 infection may be associated with increased risk symptoms. Long resolve spontaneously persist, depending type established treatments lacking, various psychological pharmacological attempted. Vaccination against plays a key role in prevention disease. With differences among SARS-CoV-2 variants, including omicron variant, likely to change future. Further studies clarifying effective warranted.

Language: Английский

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Long COVID and neuropsychiatric manifestations (Review)

Experimental and Therapeutic Medicine, Journal Year: 2022, Volume and Issue: 23(5)

Published: April 1, 2022

There is accumulating evidence in the literature indicating that a number of patients with coronavirus disease 2019 (COVID‑19) may experience range neuropsychiatric symptoms, persisting or even presenting following resolution acute COVID‑19. Among manifestations more frequently associated 'long COVID' are depression, anxiety, post‑traumatic stress disorder, sleep disturbances, fatigue and cognitive deficits, can potentially be debilitating negatively affect patients' wellbeing, albeit majority cases symptoms tend to improve over time. Despite variations results obtained from studies using different methodological approaches define syndrome, most widely accepted factors higher risk developing include severity foregoing COVID‑19, female sex, presence comorbidities, history mental health an elevation levels inflammatory markers, further research required establish causal associations. To date, pathophysiological mechanisms implicated remain only partially elucidated, while role indirect effects COVID‑19 pandemic, such as social isolation uncertainty concerning social, financial recovery post‑COVID, have also been highlighted. Given alarming 'long‑COVID', interdisciplinary cooperation for early identification who at high persistent presentations, beyond recovery, crucial ensure appropriate integrated physical support provided, aim mitigating risks long‑term disability societal individual level.

Language: Английский

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S1-Leitlinie Long-/Post-COVID

Pneumologie, Journal Year: 2022, Volume and Issue: 76(12), P. 855 - 907

Published: Dec. 1, 2022

The German Society of Pneumology initiated 2021 the AWMF S1 guideline Long COVID/Post-COVID. In a broad interdisciplinary approach, this was designed based on current state knowledge.The clinical recommendations describe COVID/Post-COVID symptoms, diagnostic approaches, and therapies.In addition to general consensus introduction, subject-specific approach taken summarize has an explicit practical claim will be developed adapted by author team increase in knowledge.Die Deutsche Gesellschaft für Pneumologie hat die S1-Leitlinie Long-/Post-COVID initiiert. einem breiten interdisziplinären Ansatz wurde diese basierend auf dem aktuellen Wissensstand gestaltet.Die klinische Empfehlung beschreibt Long- bzw. Post-COVID-Symptome, diagnostische Ansätze und Therapien.Neben der allgemeinen konsentierten Einführung ein fachspezifischer Zugang gewählt, den zusammenfasst.Die Leitlinie einen explizit praktischen Anspruch wird Wissenszugewinn vom Autorenteam weiterentwickelt adaptiert.

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COVID-19 vaccination for the prevention and treatment of long COVID: A systematic review and meta-analysis

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 111, P. 211 - 229

Published: March 27, 2023

Language: Английский

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Lipopolysaccharide-induced depression-like model in mice: meta-analysis and systematic evaluation

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 8, 2023

Depression is a complex and biologically heterogeneous disorder. Recent studies have shown that central nervous system (CNS) inflammation plays key role in the development of depression. Lipopolysaccharide (LPS)-induced depression-like model mice commonly used to studying mechanisms inflammation-associated depression therapeutic effects drugs. Numerous LPS-induced models exist differ widely animal characteristics methodological parameters. Here, we systematically reviewed on PubMed from January 2017 July 2022 performed cardinal 170 meta-analyses 61 support finding suitable for future experimental Mouse strains, LPS administration, behavioral outcomes these been assessed. In meta-analysis, forced swimming test (FST) was evaluate effect size different mouse strains doses. The results revealed large sizes ICR Swiss mice, but less heterogeneity C57BL/6 mice. For intraperitoneal dose, difference did not affect However, most significant observed after injection 0.5 mg/kg LPS. Our suggests administration play evaluation such models.

Language: Английский

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A hidden pandemic? An umbrella review of global evidence on mental health in the time of COVID-19

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: March 8, 2023

Background The mental health impacts of the COVID-19 pandemic remain a public concern. High quality synthesis extensive global literature is needed to quantify this impact and identify factors associated with adverse outcomes. Methods We conducted rigorous umbrella review meta-review present (a) pooled prevalence probable depression, anxiety, stress, psychological distress, post-traumatic (b) standardised mean difference in depression anxiety pre-versus-during period, (c) comprehensive narrative poorer Databases searched included Scopus, Embase, PsycINFO, MEDLINE dated March 2022. Eligibility criteria systematic reviews and/or meta-analyses, published post-November 2019, reporting data English on outcomes during pandemic. Findings Three hundred thirty-eight were included, 158 which incorporated meta-analyses. Meta-review symptoms ranged from 24.4% (95%CI: 18–31%, I 2 : 99.98%) for general populations 41.1% 23–61%, 99.65%) vulnerable populations. Prevalence depressive 22.9% 17–30%, 99.99%) 32.5% 17–52%, 99.35) distress PTSD/PTSS 39.1% 34–44%; 99.91%), 44.2% 32–58%; 99.95%), 18.8% 15–23%; 99.87%), respectively. comparing pre-COVID-19 revealed standard differences 0.20 (95%CI = 0.07–0.33) 0.29 0.12–0.45), Conclusion This first synthesise longitudinal show that significantly higher than pre-COVID-19, provide some evidence adolescents, pregnant postpartum people, those hospitalised experienced heightened health. Policymakers can modify future responses accordingly mitigate such measures

Language: Английский

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