Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency

Nutrients, Journal Year: 2021, Volume and Issue: 13(4), P. 1136 - 1136

Published: March 30, 2021

Magnesium plays an important role in many physiological functions. Habitually low intakes of magnesium and general the deficiency this micronutrient induce changes biochemical pathways that can increase risk illness and, particular, chronic degenerative diseases. The assessment status is consequently great importance, however, its evaluation difficult. measurement serum concentration most commonly used readily available method for assessing status, even if levels have no reliable correlation with total body or concentrations specific tissues. Therefore, review offers overview recent insights into from multiple perspectives. Starting a point view, it aims at highlighting due to insufficient uptake (frequently content modern western diet), suggesting strategies reach recommended dietary reference values, focusing on importance detecting pathological various districts, order counteract social impact diseases linked deficiency.

Language: Английский

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Nutrients and Dietary Patterns Related to Osteoporosis

Nutrients, Journal Year: 2020, Volume and Issue: 12(7), P. 1986 - 1986

Published: July 3, 2020

Osteoporosis is a common chronic disease characterized by decrease in bone mineral density, impaired strength, and an increased risk of fragility fractures. Fragility fractures are associated with significant morbidity, mortality disability major public health problem worldwide. The influence nutritional factors on the development progression this can be not yet well established. Calcium intake vitamin D status considered to essential for metabolism homeostasis. However, some recent studies have questioned usefulness calcium supplements decreasing adequate protein, vegetables other nutrients also interest, recommendations been established expert consensus clinical practice guidelines. It important understand only isolation but context dietary pattern, which complex mixture nutrients. In review, we evaluate available scientific evidence effects main patterns health. Although seem beneficial effects, more needed fully elucidate true diet fragility.

Language: Английский

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An update on magnesium and bone health

BioMetals, Journal Year: 2021, Volume and Issue: 34(4), P. 715 - 736

Published: May 6, 2021

Abstract In 2009 EFSA Panel concludes that a cause and effect relationship has been established between the dietary intake of magnesium (Mg) maintenance normal bone. After 2009, numerous studies have published, but no reviews made an update on this topic. So, aim narrative review was to consider state art since Mg blood levels, supplementation (alone or with other micronutrients; last topic considered 1990, because it is not included in claims) bone health humans. This 28 eligible studies: nine concern blood, 12 seven supplementation, alone combination nutrients. From various carried out serum concentration its bone, shown lower values are related presence osteoporosis, about 30–40% subjects analyzed (mainly menopausal women) hypomagnesaemia. Various dietetic investigations many people (about 20%) constantly consume quantities than recommended; moreover, category, mineral density higher fracturing risk found. Considering intervention published date Mg, most used form citrate, carbonate oxide, dosage varying 250 1800 mg. all there benefit both terms fracture risk.

Language: Английский

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Overview of the vital roles of macro minerals in the human body

Journal of Trace Elements and Minerals, Journal Year: 2023, Volume and Issue: 4, P. 100076 - 100076

Published: June 1, 2023

Macro minerals, also known as macro elements, are minerals that required in large amounts the human body. part of biological structure body, play an important role metabolic processes, and participate almost all processes occur can be toxic if consumed quantities for extended period. There is some evidence to suggest calcium intake may associated with a lower risk obesity. However, relationship between obesity not well understood, more research needed fully understand link. Calcium has been studied its potential development certain types cancer, specifically colorectal breast prostate cancer. higher A deficiency macroelement refers lack one or essential by humans. Macroelement deficiencies lead various health problems, such anemia, osteoporosis, muscle weakness, corrected. The macroelements blood cause many chronic diseases. Hormonal changes resulting from have consequences weight gain, obesity, increased cancer future. It maintain balanced diet ensure adequate elements.

Language: Английский

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Calcium, vitamin D, vitamin K2, and magnesium supplementation and skeletal health

Maturitas, Journal Year: 2020, Volume and Issue: 140, P. 55 - 63

Published: May 30, 2020

Language: Английский

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Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease

Antioxidants, Journal Year: 2020, Volume and Issue: 9(10), P. 907 - 907

Published: Sept. 23, 2020

Hypomagnesemia is commonly observed in heart failure, diabetes mellitus, hypertension, and cardiovascular diseases. Low serum magnesium (Mg) a predictor for all-cause mortality treating Mg deficiency may help prevent disease. In this review, we discuss the possible mechanisms by which plays detrimental roles diseases review results of clinical trials supplementation arrhythmias other

Language: Английский

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Vitamin D and the Host-Gut Microbiome: A Brief Overview

ACTA HISTOCHEMICA ET CYTOCHEMICA, Journal Year: 2020, Volume and Issue: 53(3), P. 33 - 42

Published: June 15, 2020

There is a growing body of evidence for the effects vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights potential links between health, emphasizing role in microbiological immunological mechanisms inflammatory diseases. A comprehensive literature search was carried out PubMed Google Scholar using combinations keywords "vitamin D," "intestines," "gut microflora," "bowel inflammation". Only articles published English study topic are included review. We discuss how (a) modulates microbiome function, (b) controls antimicrobial peptide expression, (c) has protective effect epithelial barriers mucosa. Vitamin its nuclear receptor (VDR) regulate barrier integrity, control innate adaptive immunity gut. Metabolites from microbiota may also expression VDR, while influence exert anti-inflammatory immune-modulating effects. The underlying mechanism pathogenesis diseases not fully understood, but maintaining an optimal status appears be beneficial health. Future studies will shed light molecular through which VDR affect mucosal immunity, pathogen invasion, symbiont colonization, expression.

Language: Английский

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MILK Symposium review: The importance of milk and dairy foods in the diets of infants, adolescents, pregnant women, adults, and the elderly

Journal of Dairy Science, Journal Year: 2020, Volume and Issue: 103(11), P. 9681 - 9699

Published: Oct. 14, 2020

Language: Английский

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Zinc Adequacy Is Essential for the Maintenance of Optimal Oral Health

Nutrients, Journal Year: 2020, Volume and Issue: 12(4), P. 949 - 949

Published: March 30, 2020

Zinc, a metal found in the Earth's crust, is indispensable for human health. In body, around 60% of zinc present muscles, 30% bones, and remaining 10% skin, hair, pancreas, kidneys plasma. An adequate balance essential maintenance skeletal growth, development function. It also necessary basic cellular functions including enzyme activation, cell signaling energy metabolism. Inadequate status associated with wide variety systemic disorders cardiovascular impairment, musculoskeletal dysfunctions oromaxillary diseases. this article, we briefly discuss role deficiency genesis various diseases, explain why homeostasis vital oral general

Language: Английский

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Ozone Layer Depletion and Emerging Public Health Concerns - An Update on Epidemiological Perspective of the Ambivalent Effects of Ultraviolet Radiation Exposure

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: March 10, 2022

Solar ultraviolet (UV) radiation exposure is the primary etiological agent responsible for developing cutaneous malignancies. Avoiding excessive exposure, especially by high-risk groups, recommended to prevent UV-induced photo-pathologies. However, optimal sun essential healthy synthesis of about 90% vitamin D levels in body. Insufficient UV-B linked deficiency humans. Therefore, necessary maintaining a normal state homeostasis skin. Humans worldwide face major existential threat because climate change which has already shown its effects several ways. Over last 4 5 decades, increased incidences skin cancer cases have led international health organizations develop strong protection measures. at same time, growing concern creating kind dilemma. Current knowledge UV outweighs adverse than beneficial roles it offers body, necessitating correct public recommendation on exposure. Following an appropriate will lead positive outcomes protecting humans against strict recommendations In this short review, we spotlight ambivalent and how ozone layer depletion influenced these UVR. Further, our aim remains explore towards balanced measures spurt diseases due inadequate UV-B.

Language: Английский

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