Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity

Nutrients, Journal Year: 2020, Volume and Issue: 12(11), P. 3361 - 3361

Published: Oct. 31, 2020

Vitamin D deficiency co-exists in patients with COVID-19. At this time, dark skin color, increased age, the presence of pre-existing illnesses and vitamin are features severe COVID disease. Of these, only is modifiable. Through its interactions a multitude cells, may have several ways to reduce risk acute respiratory tract infections COVID-19: reducing survival replication viruses, inflammatory cytokine production, increasing angiotensin-converting enzyme 2 concentrations, maintaining endothelial integrity. Fourteen observational studies offer evidence that serum 25-hydroxyvitamin concentrations inversely correlated incidence or severity The date generally satisfies Hill’s criteria for causality biological system, namely, strength association, consistency, temporality, gradient, plausibility (e.g., mechanisms), coherence, although experimental verification lacking. Thus, seems strong enough people physicians can use recommend supplements prevent treat COVID-19 light their safety wide therapeutic window. In view public health policy, however, results large-scale randomized controlled trials required currently progress.

Language: Английский

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Dietary Supplements during COVID-19 Outbreak. Results of Google Trends Analysis Supported by PLifeCOVID-19 Online Studies

Nutrients, Journal Year: 2020, Volume and Issue: 13(1), P. 54 - 54

Published: Dec. 27, 2020

The use of dietary supplements (DSs) has been steadily increasing all over the world and additionally, sales DSs have dynamical increased in wake coronavirus disease 2019 (COVID-19) most countries. We investigated phenomenon 2020 through (1) exploration Google searches worldwide Poland (with Trends (GT) tool), (2) analyses results PLifeCOVID-19 Online Studies conducted during first second wave pandemic. GT analysis cross-sectional studies revealed that COVID-19 outbreak March 2020, interest immune-related compounds foods like vitamins C D, zinc, omega-3, garlic, ginger, or turmeric, as well their consumption increased. Improving immunity was main reason behind supplementation changes pro-healthy foods. shown these interests were positively correlated with COVID-19, but adversely cumulative cases deaths. Respondents tended to start rather than one. Except for role D C, selenium patients deficiencies those nutrients, there are no clear convincing support prevention treatment healthy, well-nourished individuals. Moreover, risk elevated intake some nutrients due popularity exists, effective education consumers rationale health-protecting behaviors against should be developed.

Language: Английский

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Association of Vitamin D Status with SARS-CoV-2 Infection or COVID-19 Severity: A Systematic Review and Meta-analysis

Advances in Nutrition, Journal Year: 2021, Volume and Issue: 12(5), P. 1636 - 1658

Published: Jan. 22, 2021

Language: Английский

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Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis

Journal of Endocrinological Investigation, Journal Year: 2021, Volume and Issue: 45(1), P. 53 - 68

Published: June 24, 2021

Language: Английский

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Nutrition in the Actual COVID-19 Pandemic. A Narrative Review

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 1924 - 1924

Published: June 3, 2021

The pandemic of Coronavirus Disease 2019 (COVID-19) has shocked world health authorities generating a global crisis. present study discusses the main finding in nutrition sciences associated with COVID-19 literature. We conducted consensus critical review using primary sources, scientific articles, and secondary bibliographic indexes, databases, web pages. method was narrative literature available regarding interventions nutrition-related factors during pandemic. search engines used research were PubMed, SciELO, Google Scholar. found how lockdown promoted unhealthy dietary changes increases body weight population, showing obesity low physical activity levels as increased risk affection physiopathology. In addition, hospitalized patients presented malnutrition deficiencies vitamin C, D, B12 selenium, iron, omega-3, medium long-chain fatty acids highlighting potential effect C D interventions. Further investigations are needed to show complete role implications both prevention treatment COVID-19.

Language: Английский

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Association of vitamin D status with COVID-19 and its severity

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2022, Volume and Issue: 23(3), P. 579 - 599

Published: Jan. 4, 2022

Language: Английский

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Effects of Vitamin D Supplementation on COVID-19 Related Outcomes: A Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2022, Volume and Issue: 14(10), P. 2134 - 2134

Published: May 20, 2022

The COVID-19 outbreak has rapidly expanded to a global pandemic; however, our knowledge is limited with regards the protective factors against this infection. aim of systematic literature review and meta-analysis was evaluate impact vitamin D supplementation on related outcomes. A search relevant papers published until January 2022 conducted identify randomized controlled trials (RCTs) non-randomized studies intervention (NRISs). primary outcomes included risk infection (primary prevention uninfected individuals), hospital admission (secondary mild cases), ICU mortality rate (tertiary hospitalized patients). We identified five (one RCT, four NRISs) prevention, (two RCTs, three secondary 13 (six seven tertiary prevention. Pooled analysis showed no significant effect No possible hospitalization due paucity data. Vitamin significantly associated reduced (RR = 0.35, 95% CI: 0.20, 0.62) 0.46, 0.30, 0.70). had infection, whereas it effects in patients.

Language: Английский

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The Pathophysiology of Long COVID throughout the Renin-Angiotensin System

Molecules, Journal Year: 2022, Volume and Issue: 27(9), P. 2903 - 2903

Published: May 2, 2022

COVID-19 has expanded across the world since its discovery in Wuhan (China) and had a significant impact on people's lives health. Long COVID is term coined by World Health Organization (WHO) to describe variety of persistent symptoms after acute SARS-CoV-2 infection. been demonstrated affect various SARS-CoV-2-infected persons, independently disease severity. The long COVID, like COVID-19, consist set damage organs systems such as respiratory, cardiovascular, neurological, endocrine, urinary, immune systems. Fatigue, dyspnea, cardiac abnormalities, cognitive attention impairments, sleep disturbances, post-traumatic stress disorder, muscle pain, concentration problems, headache were all reported COVID. At molecular level, renin-angiotensin system (RAS) heavily involved pathogenesis this illness, much it phase viral In review, we summarize several tissues, with special focus significance RAS pathogenesis. risk factors potential therapy approaches are also explored.

Language: Английский

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High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): A multicenter, open-label, randomized controlled superiority trial

PLoS Medicine, Journal Year: 2022, Volume and Issue: 19(5), P. e1003999 - e1003999

Published: May 31, 2022

Background Vitamin D supplementation has been proposed as a treatment for Coronavirus Disease 2019 (COVID-19) based on experimental data and from small uncontrolled observational studies. The COvid19 VITamin d TRIAL (COVIT-TRIAL) study was conducted to test whether single oral high dose of cholecalciferol (vitamin D3) administered within 72 hours after the diagnosis COVID-19 improves, compared standard-dose cholecalciferol, 14-day overall survival among at-risk older adults infected with Severe Acute Respiratory Syndrome 2 (SARS-CoV-2). Methods findings This multicenter, randomized, controlled, open-label, superiority trial involved collaboration 9 medical centers in France. Patients admitted hospital units or living nursing homes adjacent investigator were eligible if they ≥65 years, had SARS-CoV-2 infection less than 3 days, at least 1 worsening risk factor (among age ≥75 SpO2 ≤94%, PaO /FiO ≤300 mm Hg). Main noninclusion criteria organ failure requiring ICU, ≤92% despite 5 L/min oxygen, life expectancy <3 months, vitamin >800 IU/day during preceding month, contraindications supplements. Eligible consenting patients randomly allocated either high-dose (400,000 IU) (50,000 under supervision COVID-19. Participants local staff not masked treatment, but Steering Committee Data Safety Monitoring Board randomization group outcome trial. primary mortality. Between April 15 December 17, 2020, 1,207 who assessed eligibility COVIT-TRIAL study, 254 met formed intention-to-treat population. median 88 (IQR, 82 92) 148 (58%) women. Overall, 8 (6%) 127 14 (11%) died days (adjusted hazard ratio = 0.39 [95% confidence interval [CI], 0.16 0.99], P 0.049, controlling strata [i.e., age, oxygen requirement, hospitalization, use antibiotics, anti-infective drugs, and/or corticosteroids] baseline imbalances important prognostic factors sex, ongoing cancers, profuse diarrhea, delirium baseline]). number needed treat one person benefit (NNTB) 21 [NNTB ∞ harm (NNTH) 46]. Apparent benefits also found mortality due (7 deaths group; adjusted 0.33 CI, 0.12 0.86], 0.02). protective effect administration sustained 28 (19 (15%) (17%) 0.70 0.36 1.36], 0.29). High-dose did result more frequent adverse effects standard dose. open-label design limited power are main limitations study. Conclusions In this randomized controlled (RCT), we observed that early versus D3 improved day 14. no longer days. Trial registration ClinicalTrials.gov NCT04344041 .

Language: Английский

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Protective Effect of Vitamin D Supplementation on COVID-19-Related Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and Trial Sequential Analysis

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(1), P. 130 - 130

Published: Jan. 16, 2023

Background: The COVID-19 pandemic represents one of the world’s most important challenges for global public healthcare. Various studies have found an association between severe vitamin D deficiency and COVID-19-related outcomes. Vitamin plays a crucial role in immune function inflammation. Recent data suggested protective health purpose this meta-analysis trial sequential analysis (TSA) was to better explain strength supplementation risk mortality admission intensive care units (ICUs) patients with COVID-19. Methods: We searched four databases on 20 September 2022. Two reviewers screened randomized clinical trials (RCTs) assessed bias, independently duplicate. pre-specified outcomes interest were ICU admission. Results: identified 78 bibliographic citations. After reviewers’ screening, only five RCTs be suitable our analysis. performed meta-analyses then TSAs. administration results decreased death (standardized mean difference (95% CI): 0.49 (0.34–0.72) 0.28 (0.20–0.39), respectively). TSA showed that, since pooling reached definite sample size, positive is conclusive. that z-curve inside alpha boundaries, indicating need further studies. Discussion: respective TSAs suggest definitive hospitalization.

Language: Английский

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