International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(20), P. 15058 - 15058
Published: Oct. 11, 2023
OPMDs
(oral
potentially
malignant
disorders)
are
a
group
of
disorders
affecting
the
oral
mucosa
that
characterized
by
aberrant
cell
proliferation
and
higher
risk
transformation.
Vitamin
D
(VitD)
its
receptor
(VDR)
have
been
extensively
studied
for
their
potential
contributions
to
prevention
therapeutic
management
various
diseases
neoplastic
conditions,
including
cancer.
Observational
studies
suggest
correlations
between
VitD
deficiency
cancer
risk,
worse
prognosis,
increased
mortality
rates.
Interestingly,
emerging
data
also
link
insufficiency
onset
or
progression
OPMDs.
Understanding
role
VitD–VDR
axis
not
only
in
established
tumors
but
might
thus
enable
early
detection
With
this
article,
we
want
provide
an
overview
current
knowledge
about
investigate
association
ramifications
clinical
EFSA Journal,
Journal Year:
2023,
Volume and Issue:
21(8)
Published: Aug. 1, 2023
Following
two
requests
from
the
European
Commission
(EC),
EFSA
Panel
on
Nutrition,
Novel
Foods
and
Food
Allergens
(NDA)
was
asked
to
deliver
a
scientific
opinion
revision
of
tolerable
upper
intake
level
(UL)
for
vitamin
D
propose
conversion
factor
(CF)
calcidiol
monohydrate
into
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(7), P. 6774 - 6774
Published: April 5, 2023
Periodontitis
is
a
common
disorder
affecting
the
bone
and
soft
tissues
of
periodontal
complex.
When
untreated,
it
may
lead
to
severe
mobility
or
even
loss
teeth.
The
pathogenesis
periodontitis
complex,
with
crucial
factors
being
chronic
inflammation
in
gingival
oral
microbiome
alterations.
However,
recent
studies
highlight
alleged
role
vitamins,
such
as
vitamin
C
(VitC)
D
(VitD),
development
disease.
VitC
regulates
numerous
biochemical
reactions,
but
foremost,
involved
synthesizing
collagen.
It
was
reported
that
deficiency
could
damage
ligaments.
supplementation
improves
postoperative
outcomes
patients
periodontitis.
VitD
steroid
derivative
can
be
produced
skin
under
ultraviolet
radiation
later
transformed
into
an
active
form
other
tissues,
kidneys.
established
decrease
expression
proinflammatory
cytokines
gingiva
regulate
proper
mineral
density
Moreover,
associated
better
results
nonsurgical
treatment
In
this
review,
we
summarize
knowledge
on
vitamins
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(9), P. 1345 - 1345
Published: April 29, 2024
This
review
aims
to
evaluate
the
efficacy
of
any
vitamin
administration(s)
in
preventing
and
managing
COVID-19
and/or
long-COVID.
Databases
were
searched
up
May
2023
identify
randomized
clinical
trials
comparing
data
on
effects
supplementation(s)
versus
placebo
or
standard
care
two
conditions
interest.
Inverse-variance
random-effects
meta-analyses
conducted
estimate
pooled
risk
ratios
(RRs)
95%
confidence
intervals
(CIs)
for
all-cause
mortality
between
supplemented
non-supplemented
individuals.
Overall,
37
articles
included:
regarded
long-COVID
prevention
35
records
management.
The
D
contrasting.
Similarly,
no
conclusion
could
be
drawn
multivitamins,
A,
B
A
few
positive
findings
reported
some
C
but
results
inconsistent
most
outcomes,
excluding
(RR
=
0.84;
CI:
0.72–0.97).
Vitamin
mixed
aspects,
including
mortality,
which
benefits
observed
regular
administrations
only
0.67;
0.49–0.91).
Despite
benefits,
mostly
contradictory.
Variety
recruitment
treatment
protocols
might
explain
this
heterogeneity.
Better-designed
studies
are
needed
clarify
these
vitamins’
potential
against
SARS-CoV-2.
Endocrines,
Journal Year:
2025,
Volume and Issue:
6(1), P. 10 - 10
Published: March 4, 2025
A
balanced
diet
and
regular
physical
activity
are
essential
for
maintaining
musculoskeletal
health.
Key
nutrients
such
as
calcium,
vitamin
D,
protein
especially
important
preventing
falls
fractures.
While
the
benefits
of
these
well-established,
other
dietary
components
have
not
been
studied
extensively.
For
instance,
vegetables,
which
rich
in
vital
muscle
bone
health,
play
a
crucial
role
Over
recent
decades,
great
emphasis
has
given
to
combinations
foods
patterns
that
may
synergistic
or
antagonistic
effects.
Despite
challenges
researching
impact
nutrition
on
health
due
extensive
heterogeneity
results,
healthcare
professionals
should
continue
promote
healthy
eating
activity,
principles
be
emphasized
public
initiatives.
Ultimately,
sufficient
diet,
abundant
plant-based
low
processed
discretionary
foods,
along
with
consistent
remains
most
effective
strategy
prevention
issues.
This
article
aims
review
updated
literature
years
links
between
skeletal
Poultry Science,
Journal Year:
2025,
Volume and Issue:
unknown, P. 105145 - 105145
Published: April 1, 2025
Tibia
disorders
in
modern
ducks
are
frequently
associated
with
rapid
weight
gain
and
compromised
bone
quality,
which
is
defined
as
the
structural
material
properties
of
tissue
that
determines
its
strength
fracture
resistance.
These
factors
significantly
increase
risk
fractures
chronic
pain.
Studies
suggest
25-hydroxycholecalciferol
(25-OH-D3),
a
vitamin
D3
metabolite,
effectively
addresses
disorders,
potentially
depending
on
dietary
regimens,
determined
by
amount
ratio
vitamins
diet.
This
study
used
2
×
factorial
design
to
evaluate
effects
two
regimens
(regular
high)
or
without
exogenous
25-OH-D3
(0.069
mg/kg)
leg
health
tibia
quality
meat
(1-14
d).
The
high-vitamin
regimen
contained
greater
amounts
all
except
biotin
enhanced
ash
content,
tibial
microstructure,
load,
reduced
dyschondroplasia
(TD)
scores
(P
<
0.05)
compared
regular
regimen,
despite
no
impact
growth
performance
length,
weight,
diameter
>
0.05).
Additionally,
supplementation
increased
0.05),
improved
strengthened
formation
resorption
processes.
Notably,
under
TD
gain,
mechanical
properties,
serum
content
procollagen
type
I
N-terminal
propeptide
(PN1P)
marker
(all
P
However,
these
were
diminished
fed
There
some
interactions
noticed
regarding
trabecular
area,
PN1P
levels
present
In
conclusion,
biochemical
influenced
baseline
vitamins,
diet
treatment
enhancing
formation.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(11), P. 1754 - 1754
Published: June 3, 2024
Background:
We
assessed
the
long-term
(24
months)
efficacy
and
safety
of
monthly
calcifediol
(0.266
mg)
in
correction
maintenance
total
25(OH)D
levels
postmenopausal
women
with
basal
values
<30
ng/mL.
Methods:
initially
enrolled
45
consecutive
patients
during
period
September
2019–September
2020.
After
an
initial
visit,
were
instructed
to
return
at
3,
6,
9,
12
24
months
for
measuring
serum
25(OH)D,
ionised
calcium,
creatinine
isoenzyme
alkaline
phosphatase
(bALP).
Here,
we
report
only
per-protocol
analysis,
because
COVID-19
pandemic
precluded
adherence
scheduled
visits
some
patients.
Results:
The
patients’
mean
age
was
62.4
±
9.0
years.
Mean
20.5
5.3
There
a
continuous
increase
(p
trend
<
0.001).
However,
month
(36.7
15.9)
not
significantly
different
respect
(41.2
11.18).
At
months,
1
out
19
had
value
<20
significant
decrease
time
bALP
0.0216),
no
changes
between
months.
No
observed
as
far
calcium
or
concerned.
Conclusions:
administration
maintains
stable
sustained
concentrations,
concerns.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(20), P. 4409 - 4409
Published: Oct. 17, 2023
Due
to
its
essential
role
in
calcium
and
phosphate
homeostasis,
the
secosteroid
hormone
calcitriol
has
received
growing
attention
over
last
few
years.
Calcitriol,
like
other
steroid
hormones,
may
function
through
both
genomic
non-genomic
mechanisms.
In
traditional
function,
interaction
between
biologically
active
form
of
vitamin
D
receptor
(VDR)
affects
transcription
thousands
genes
by
binding
repeated
sequences
present
their
promoter
region,
named
D-responsive
elements
(VDREs).
Non-transcriptional
effects,
on
hand,
occur
quickly
are
unaffected
inhibitors
protein
synthesis.
Recently,
calcifediol,
immediate
precursor
metabolite
calcitriol,
also
been
shown
bind
VDR
with
weaker
affinity
than
thus
exerting
gene-regulatory
properties.
Moreover,
calcifediol
trigger
rapid
responses
specific
membrane
receptors.
Membrane-associated
(mVDR)
disulfide
isomerase
family
A
member
3
(Pdia3)
best-studied
candidates
for
mediating
these
metabolites.
This
paper
provides
an
overview
calcifediol-related
mechanisms
action,
which
help
better
understand
endocrine
system
identify
new
therapeutic
targets
that
could
be
important
treating
diseases
closely
associated
deficiency.
Aquaculture,
Journal Year:
2024,
Volume and Issue:
585, P. 740687 - 740687
Published: Feb. 20, 2024
Dietary
vitamin
D
is
required
by
cultivated
fish
for
optimal
growth,
feed
utilisation
and
bone
health.
The
in
vivo
conversion
of
cholecalciferol
(D3)
to
active
hormone
(1,25-OH-D3)
may
be
impaired
farm-raised
fed
modern
formulations.
Requiring
fewer
metabolic
steps
its
conversion,
the
use
dietary
calcifediol
(25-OH-D3)
mitigate
against
deficits
metabolism.
A
90-day
experimental
feeding
trial
was
undertaken
juvenile
(23
g)
Atlantic
salmon
(Salmo
salar)
test
efficacy
25-OH-D3
added
a
standard
diet
containing
recommended
levels
D3
(5640
IU).
Test
diets
contained
100,
200
or
400
μg/kg
no
additive
control
diet.
Effects
on
zootechnical
performance,
indices
adiposity,
mineralisation,
circulating
metabolites
were
tested.
significantly
reduced
ratio
(FCR)
resulted
numerical
increases
growth
performance.
also
mesenteric
adiposity
with
concurrent
carcass
weight.
Levels
calcium,
phosphorous,
magnesium,
zinc
manganese
not
modulated
vertebrae
receiving
25-OH-D3.
Circulating
remained
below
detection
limits
1,25-OH-D3
manipulations.
significant
reduction
benefit
weight
shows
that
improves
lipids.
requirement
mineralisation
met
basal
Segmented
regression
estimates
supplementation
143
180
improved
adiposity.
lack
correlation
between
indicates
lipid
metabolism
regulated
localised
tissue
activation
D,
rather
than
endocrine
functions
1,25-OH-D3.
