FABRICATION, OPTIMIZATION AND IN VITRO CYTOTOXICITY EVALUATION OF DASATINIB MONOHYDRATE-LOADED NANOPARTICLES DOI Open Access

Ajay Saroha,

Ravinder Verma, Vineet Mittal

et al.

International Journal of Applied Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 359 - 367

Published: Sept. 7, 2024

Objective: The present research aimed to formulate, optimize and evaluate dasatinib monohydrate-loaded nanoparticles using the ionic gelation method as a potential anticancer drug delivery system for enhancing its dissolution rate. Methods: Box-Behnken design was implemented study effects of selected parameters chitosan concentration (X1), Sodium Tripolyphosphate (NaTPP) (X2), NaTPP volume (X3) on release from developed nanoparticles. Moreover, optimized formulation evaluated various parameters, including X-ray diffraction, differential scanning calorimetry, fourier transform infra-red, in vitro kinetics. Then, cytotoxicity executed via MTT assay leukemia cell lines (RPMI 8226). Results: results showed optimal conditions maximum encapsulation efficiency minimum particle size were low concentration, medium high volume. batch (NP-7) demonstrated promising with an 83.12±0.17%, 96.8 nm, cumulative 91.37±0.49% after 24 h. monohydrate higher when administered polymeric compared pure form. Conclusion: From this research, it can be concluded that enhanced loaded into

Language: Английский

Nanocarriers in Tuberculosis Treatment: Challenges and Delivery Strategies DOI Creative Commons

Mahesh Kumar,

Tarun Virmani, Girish Kumar

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(10), P. 1360 - 1360

Published: Sept. 26, 2023

The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist, they come with challenges such heavy pill regimen, prolonged treatment duration, and strict schedule, to multidrug-resistant (MDR) extensively drug-resistant (XDR) strains. rise of MDR strains endangers future control. Despite these concerns, the hunt an efficient continues. One breakthrough has been use nanotechnology in medicines, presenting novel approach treatment. Nanocarriers, lipid nanoparticles, nanosuspensions, liposomes, polymeric micelles, facilitate targeted delivery anti-TB drugs. benefits nanocarriers include reduced drug doses, fewer side effects, improved solubility, better bioavailability, patient compliance, speeding up recovery. Additionally, can be made even more linking them ligands mannose or hyaluronic acid. This review explores innovative treatments, including studies on containing drugs related patents.

Language: Английский

Citations

22
The role of tetrahydrocurcumin in disease prevention and treatment DOI
Mengting Zhou, Rui Li, Hua Hua

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(13), P. 6798 - 6824

Published: Jan. 1, 2024

In recent decades, natural compounds derived from herbal medicine or dietary sources have played important roles in prevention and treatment of various diseases attracted more attention. Curcumin, extracted the

Language: Английский

Citations

6
Co-Delivery of Naringin and Ciprofloxacin by Oleic Acid Lipid Core Encapsulated in Carboxymethyl Chitosan/Alginate Nanoparticle Composite for Enhanced Antimicrobial Activity DOI Creative Commons
Tahani M. Almeleebia, Md Habban Akhter, Habibullah Khalilullah

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(6), P. 6845 - 6860

Published: Feb. 2, 2024

A novel combination of antibiotic, ciprofloxacin (CIP) with herbal counterpart naringin (NAR) was encapsulated by an oleic acid lipid core and carboxymethyl chitosan (CM–CS)/Alginate (AG) nanoparticle composite (CIP + NAR–CM–CS/AG–NPs) for improved antimicrobial efficacy antibiotic. Herein, this study explored the design preparation a system that enables to deliver both CIP NAR from CM–CS/AG nanoparticles using nonsolvent ionic gelation technique. The (NPs) were fabricated long-acting activity against E. coli S. aureus. optimized composition investigated physicochemical properties particle size, distribution, ζ–potential. diverse array analytical tools employed characterize formulation including DSC, XRD, Malvern Zetasizer ζ–potential, TEM, SEM. Further, % drug release, flux determination, antioxidant, activity. stability tested 90 days also evaluated in fetal bovine serum inspect modification characteristics. NPs size determined at 85 nm, PDI, ζ–potential recorded 0.318, 0.7 ± 0.4 mV. entrapment efficiency loading incurred as 91 1.9, 89.5 1.2; 11.5 0.6, 10.8 0.5%, respectively. release erupted beginning phase followed sustained prolonged 48 h. experiments DSC ensured noninteracting safe use excipients combination. X–ray studies demonstrated amorphous state formulation. insignificant alteration characteristics FBS suggested stable robust preparation. Storage developed consistent uniform three months. DPPH assays had good antioxidant capacity supported improving CIP. hemolytic test compatible caused RBC destruction. in-house built NAR–CM–CS/AG–NPs significantly compared alone, offering choice application.

Language: Английский

Citations

5
Design and optimization of chitosan-coated solid lipid nanoparticles containing insulin for improved intestinal permeability using piperine DOI

Indu Raghunath,

Marina Koland,

C. Sarathchandran

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135849 - 135849

Published: Sept. 1, 2024

Language: Английский

Citations

5
Hesperetin-supplemented soybean and ginger hydroalcoholic extracts alleviate diabetic cardiomyopathy in streptozotocin induced diabetic rats by modulating NF-κB/MMP-9/TIMPs pathway DOI

Ritu,

Ravinder Verma,

S. Kaushik

et al.

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 179, P. 11 - 21

Published: Feb. 8, 2025

Language: Английский

Citations

0
Nanocarriers and their Integrated Microneedle Systems-Mediated Drug Delivery for the Treatment of Moderate-Severe Dermatological Diseases: Recent Progress, Applications and Future Perspectives DOI
Mridusmita Das, Rabinarayan Parhi

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106748 - 106748

Published: Feb. 22, 2025

Language: Английский

Citations

0
RECENT ADVANCES IN TREATMENT APPROACHES FOR DIABETES MELLITUS AND RELATED COMPLICATIONS: A REVIEW DOI Open Access

Siddhant Dhyani,

Mansi Butola,

Vanshika Sautha

et al.

International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 12 - 30

Published: March 7, 2025

Diabetes Mellitus (DM) can be treated with a variety of therapeutic approaches. Patients are forced to initiate therapy antidiabetic agents when diet and exercise ineffective regulate hyperglycemia. However, these drugs have several disadvantages that influence the course treatment. The primary drawbacks current oral modalities for treatment DM immediate release drug low bioavailability, which necessitates an increase in frequency dosing. Patient compliance decreases conjunction manifestation adverse side effects. development innovative delivery potential improve efficacy anti-diabetic regimens has been fertile area nanotechnology recent years. objective all attempts (a) safeguard by encapsulating it nano-carrier system (b) controlled progressive manner using effective techniques. review aims compile nanocarriers like polymeric nanoparticles (NPs), liposomes, niosomes, dendrimers, micelles, solid lipid NPs, transfersomes, ethosomes, nanofibers, carbon nanotubes diabetes mellitus, emerging strategies various complications related this disease.

Language: Английский

Citations

0
Nanocarrier-Based Approach: Solid Lipid Nanoparticles for the Enhanced Bioavailability of Febuxostat DOI

Shehram Qazafi,

Danish Mazhar,

Dur e Nayab

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 20, 2025

Language: Английский

Citations

0
Multifaceted Applications of Solid Lipid: A Comprehensive Review DOI
Chinam Niranjan Patra, Kartikesh Sahu, R. K. Singha

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(2), P. 834 - 860

Published: Feb. 5, 2024

Lipids originate from plant and animal sources have significant roles in various fields, like pharmaceuticals, cosmetics, food, paint, leather, agriculture, microfluidics, oil industries. Over the years, with development of technology, different types lipids been synthesized or extracted used based on their industrial need. are heterogeneous group compounds related to fatty acids insoluble water but soluble organic solvents. One category great importance is solid lipids. Solid a type that remain at ambient temperature. In past, were obtained natural they mainly as bulking agents bases for dosage forms. due course time, after industrialization, evolved gained more significance. drug targeting controlled delivery release rate modifiers, solubilizers, stabilizers, permeation enhancers improved biopharmaceutical performance drugs. These also popular diversified applications industries mentioned above. this review, authors selected some Stearic acid, Compritol®ATO 888, Precirol®ATO 5, Glyceryl Monostearate, Witepsol®, Carnauba wax, Softisan®, Cholesterol, Dynasan®, Cetyl palmitate discussed about properties applications.

Language: Английский

Citations

3
Supramolecular approach to the design of nanocarriers for antidiabetic drugs: targeted patient-friendly therapy DOI
Л. А. Васильева, Gulnara A. Gaynanova,

E. A. Romanova

et al.

Russian Chemical Reviews, Journal Year: 2024, Volume and Issue: 93(11), P. RCR5150 - RCR5150

Published: Oct. 30, 2024

Diabetes and its complications derived are among serious global health concerns that critically deteriorate the quality of life patients and, in some cases, result lethal outcome. Herein, general information on pathogenesis, factors aggravating course disease drugs used for treatment two types diabetes briefly discussed. The aim review is to introduce supramolecular strategies currently being developed mellitus present a very effective alternative chemical synthesis, allowing fabrication nanocontainers with switchable characteristics meet criteria green chemistry. Particular attention paid organic (amphiphilic polymeric) formulations, including those natural origin, due their biocompatibility, low toxicity, bioavailability. advantages limitations different nanosystems discussed, emphasis adaptivity noninvasive administration routes.<br>The bibliography includes 378 references.

Language: Английский

Citations

3