<strong>Knowing the Mechanisms: How Probiotics Affect the Development and Progression of Cancer</strong>

Published: July 4, 2023

The stability of the gut barrier is very important for keeping healthy and stopping dangerous substances from getting into bloodstream. Several diseases, including cancer, have been linked to being broken. Live bacteria called probiotics that are good host shown ability improve lower risk cancer in gastrointestinal system. This review looks at how affect health what might mean preventing cancer. Researchers found strengthen connections between intestine cells, encourage production protective mucins, change make-up balance bacteria. These processes help keep strong stop harmful chemicals Probiotics may chance by reducing inflammation throughout body protecting GI tract substances. But more study needed fully understand benefits different probiotic strains, best amounts take, they barrier. Understanding probiotics, barrier, all work together can us come up with new ways avoid treat

Language: Английский

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GC–MS based untargeted metabolomics reveals the metabolic response of earthworm (Eudrilus eugeniae) after chronic combinatorial exposure to three different pesticides

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: May 26, 2023

In this study GC-MS-based untargeted metabolomics was used to identify the metabolic response of earthworm; Eudrilus eugeniae exposed sub-lethal concentrations chlorpyrifos-CHL, cypermethrin-CYP, Glyphosate-GLY, and Combined-C (all three pesticides) at 3, 6, 12 mg/kg. Principal component analysis obtained datasets revealed a clear distinction between control treatment groups. The mean weight worms in treated groups decreased significantly (p < 0.05). Among identified metabolites, oleic acid (~ 93.47%), lysine 92.20%), glutamic 91.81%), leucine 90.20%), asparagine 94.20%), methionine 92.27%), malic 93.37%), turanose 95.04%), maltose 92.36%), cholesta-3,5-diene 86.11%), galactose 93.20%), cholesterol 91.56%), tocopherol 85.09%), 0.05), whereas myoinositol 83%) isoleucine (78.09%) increased 0.05) upon exposure CHL, CYP, GLY, C. Overall, findings suggest that earthworms might be new entry point for pesticides into food chain. present highlights can reliable approach understand effect different xenobiotics including on earthworms.

Language: Английский

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Stress as a Catalyst: Understanding its Role in Bowel Cancer

Published: March 26, 2024

Stress has been identified as a prominent contributor to the development and advancement of bowel cancer, however its specific involvement is intricate diverse. This abstract tries offer concise summary correlation between stress consolidating significant discoveries from several research fields. The investigation commences by studying molecular pathways which chronic impacts colon cancer. Chronic causes disruption in functioning neuroendocrine, immunological, inflammatory pathways, leading microenvironment within gastrointestinal system that promotes growth tumours. Furthermore, changes composition gut microbiota, variations epigenetics, alterations immune function caused also have role increasing risk advancing Psychological aspects, including how one perceives stress, tactics they use cope with it, level psychosocial support receive, are crucial determining person's susceptibility cancer impacting effectiveness treatment. management therapies, such cognitive-behavioral therapy mindfulness-based reduction, demonstrated potential enhancing patient well-being promoting adherence Moreover, epidemiological studies clinical trials vital knowledge regarding risk, prognosis, treatment results Although evidence inconclusive, it essential continue researching relationship will help us understand connection better create strategies reduce impact on outcomes.

Language: Английский

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Functional profiling of the rhizospheric Exiguobacterium sp. for dimethoate degradation, PGPR activity, biofilm development, and ecotoxicological risk

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 26, 2024

Abstract This study introduces an indigenous bacterial strain, Exiguobacterium sp. (L.O), isolated from sugarcane fields in Sevur, Tamil Nadu, which has adapted to prolonged exposure dimethoate. The strain demonstrated the capability utilize 150 ppm of dimethoate as its sole carbon source, achieving a remarkable degradation rate 95.87% within 5 days mineral salt media. Gas chromatography–mass spectrometry (GC–MS) analyses identified presence intermediate by-products formed during degradation, like methyl diethanol amine and aspartyl glycine ethyl ester. Notably, phosphorothioic O, S-acid, expected end product dimethoate, was also identified, further confirming strain’s effective metabolic breakdown pesticide. Further analysis changes functional group performed by FTIR, hypothetical pathway elucidated showing course metabolism strain. (L.O) displayed significant plant growth-promoting traits, including production HCN, IAA, ammonia formation biofilms, enhance utility agricultural applications. ecotoxicity revealed exhibited reduced toxicity compared parent compound highlighting potential not only for bioremediation but supporting sustainable practices. research presents novel application integrating organophosphate pesticide with enhancement. approach is critical addressing challenges associated pollution likely first demonstrate this suggested extensive review literature.

Language: Английский

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<strong>Probiotics Change the Microbiota: From the Lab to the Bedside</strong>

Published: July 14, 2023

Probiotics have become a potential way to change the microbiota, which allows for more personalized ways improve health results. This abstract gives an outline of most important parts microbiota regulation through probiotics. It focuses on effectiveness and mechanisms, clinical applications, safety tolerability, formulations delivery methods, customized approaches. Many studies looked into how why probiotics microbiome. These show that can makeup function microbial communities. been shown help treat number problems, such as digestive immune system metabolic mental problems. is success find out if they are safe be tolerated. Studies usually people, but there some things need taken account make sure safe, especially people who weak. Formulations transport methods very making alive, stable, delivered right places in GI tract. Probiotic strains work better gut because improvements probiotic preparation technologies protect control release strains. Personalized take each person's microbiome different. By using individual profiling, custom approaches made address specific imbalances promote healthier environment, could treatment Even though promise, still standardize profiling techniques, figure understand data, keep track over time. For reach their full patients cared based microbiota-host relationship, study, technological advances, teamwork needed. In conclusion, used your you goals. power individualized treatments might able with certain problems environment better. Putting practice changing will require study partnerships between different fields.

Language: Английский

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Dimethoate degrading efficiency of Bacillus paramycoides isolated from pesticide influenced rhizospheric soil of sugarcane field in Tamil Nadu

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 16, 2023

Abstract Pesticides are inevitable part of Indian agriculture. Statistically, India is one the top producer pesticide over world. As a developing country, abundance use quite common and organophosphates (OPP) being them. Known for causing acute toxicity, OPPs needed to be used controllably residues released into environment should treated render harmless. Biological degradation effective ways achieve that. However, exploring potential candidate purpose still not sufficient compared necessity alleviate OPP from environment. In this study, dimethoate, subclass has been studied microbial using bacteria Bacillus paramycoides , isolated rhizospheric soil sugarcane cultivation fields pre-exposed dimethoate considerable long time. The strain extensively check its prospect on environmental stress, tolerance efficiency. isolate was found degrade by 97.6% in 5 days with 1000ppm targeted pesticide. Emphasis have also made detect secondary metabolites produced GCMS analysis functional groups were confirmed FTIR. Significant biologically important obtained B.paramycoides reported study which known having anticancerous, antibacterial properties. This work presumably first communication prospecting degradation.

Language: Английский

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Probiotics in the Treatment of Gastrointestinal Disorders and What We Know About Their Effect on Microbiota

Published: Aug. 21, 2023

Modulating the gut microbiota with probiotics has been identified as a promising therapeutic method for management of gastrointestinal illnesses. The effectiveness in treatment disorders can only be determined by delving into their underlying mechanisms action. Through an analysis processes, this study hopes to provide light on potential benefits treating variety conditions. covers wide conditions, such IBS, IBD, and antibiotic-associated diarrhea. Modifying composition, strengthening barrier function, modulating immune system, producing beneficial metabolites are among action that have investigated. strain- dose-specific variables essential getting best results also highlighted. This review, which synthesizes current information, gives thorough overview illnesses illuminates avenues further use.

Language: Английский

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Probiotics in Cancer Treatment: From the Laboratory to Clinical Practice

Published: July 10, 2023

Probiotics are now being looked at as a possible addition to cancer treatments in both study and clinical settings. This tries give an overview of probiotic research it relates cancer, with focus on how might help avoid treat it, improve the health patients. We look developmental studies that use cell culture animal models well probiotics work cancer. change immune system, inflammation, gut bacteria. The results add-on therapy for patients see they affected treatment success, side effects, quality life benefits certain types such colorectal breast stomach tumors. also find best strains each type synergistic combining standard like chemotherapy, radiation therapy, immunotherapy effectiveness lower effects. Lastly, we talk about present problems future directions personalized methods, ideal doses plans, finding signs making probiotic-based therapies. By learning more could be used can create personalized, successful, well-tolerated outcomes.

Language: Английский

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Effective medium for Photorhabdus luminescens bioinsecticide production and exploration of optimal mixture with Bacillus thuringiensis subsp. aizawai against Plutella xylostella

Journal of the Taiwan Institute of Chemical Engineers, Journal Year: 2023, Volume and Issue: 160, P. 105309 - 105309

Published: Dec. 19, 2023

Plutella xylostella is a major pest of cruciferous vegetables worldwide. We evaluated biopesticide using different culture treatments Photorhabdus luminescens (ATCC 29,999) and Bacillus thuringiensis subsp. aizawai examined their insecticidal activity against Pl. xylostella. L8 L9 Taguchi orthogonal designs were adopted to evaluate the optimal medium for enhanced activity. Feeding bioassays conducted determine potential synergistic effects combining B. Ph. luminescens, most effective combination was identified by analyzing time–mortality response Analysis pH value indicates that has tolerance acidic conditions can alkalize medium. Among various combinations, optimized A3B1C3N2—d10 × concentration, 24-h cultivation time, 1.25 % molasses as carbon source, nitrogen source consisting yeast extract powder, amino acids (0.2:0.3:0.5 %)—resulted in highest insect mortality. Synergistic interactions between observed 1:1 mixture, likely due immune system suppression. These results highlight prepare potent bioinsecticide other lepidopteran pests, thereby decreasing reliance on chemical pesticides.

Language: Английский

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Cyanobacteria-microalgae consortia as bio- inoculants for enhancing soil fertility and plant growth

Published: May 1, 2024

Modern agriculture that heavily utilizes synthetic fertilizers has raised significant environmental concerns worldwide. Microalgae-based bio-inoculants have become a more viable and eco- friendly option to reduce the reliance on chemical for improving soil fertility plant growth in agronomic practices. Indigenous microalgal species can colonize thrive well under local conditions, making them well-suited use as bio-inoculants. Additionally, it appears using consortia of green microalgae nitrogen (N)-fixing cyanobacteria could be beneficial because supply carbon (C), fix C N soil. They both produce agriculturally metabolites improve nutrient availability. This synergistic relationship enhance overall effectiveness bio- inoculants promote sustainable In this study, thirteen strains were isolated from agricultural fields Durban, KwaZulu Natal, South Africa. Two N-fixing (Nostoc sp. Calothrix sp.) two (Desmodesmus armatus Chlorella selected analyzed significance development suitable N-deficient conditions. The amount indole acetic acid (IAA) biomass extracts (Calothrix (2.54 ng g−1) Nostoc (1.52 g−1)) was significantly higher than (Chlorella (0.32 Desmodesmus (0.20 g−1)). A completely randomized design used develop evaluate eight medium with strains. improvement productivity, production, nutrients viz C, N, phosphorus (P), potassium (K), calcium (Ca), copper (Cu), iron (Fe), manganese (Mn) observed consortium compared individual isolates. further biostimulant properties seed germination assay chili seeds. increase seedling length leaf number seeds treated control. pot culture study also supported effect bio-inoculant fertility, native microbiomes. Soil enzyme activity increased (p < 0.05) treatments, dehydrogenase (DHA), organic (OC), chlorophyll (Chl), total polysaccharides (TP) such P, K Mn being enriched at 100 % 50 treatment applications comparison control (Cnt). Growth responses terms shoot root (fresh dry weight), high treatments (Al(50 %)+CF(50 %)) when Cnt. With different parameters microbiome (bacterial fungal) indicators, we successfully predict inoculations. Results 16SrRNA ITS amplicon sequencing suggested bio-inoculation improved diversity composition microbiome, leading an yield. Further, shotgun metagenomics confirmed enzymatic involved P metabolisms Potential shifts microbial taxa functional genes indicated major driver metabolic change. findings microbiomes, growth, yield plants.

Language: Английский

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