<strong>Knowing the Mechanisms: How Probiotics Affect the Development and Progression of Cancer</strong>

Published: July 4, 2023

The stability of the gut barrier is very important for keeping healthy and stopping dangerous substances from getting into bloodstream. Several diseases, including cancer, have been linked to being broken. Live bacteria called probiotics that are good host shown ability improve lower risk cancer in gastrointestinal system. This review looks at how affect health what might mean preventing cancer. Researchers found strengthen connections between intestine cells, encourage production protective mucins, change make-up balance bacteria. These processes help keep strong stop harmful chemicals Probiotics may chance by reducing inflammation throughout body protecting GI tract substances. But more study needed fully understand benefits different probiotic strains, best amounts take, they barrier. Understanding probiotics, barrier, all work together can us come up with new ways avoid treat

Language: Английский

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What We Know About the Actual Role of Traditional Probiotics in Health and Disease

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: 16(5), P. 1836 - 1856

Published: May 3, 2024

Language: Английский

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Effects of antibiotic, acidifier, and probiotic supplementation on mortality rates, lipoprotein profile, and carcass traits of broiler chickens

Veterinary and Animal Science, Journal Year: 2023, Volume and Issue: 22, P. 100325 - 100325

Published: Nov. 28, 2023

Antimicrobial resistance is a significant issue, therefore it's relevant to assess the effects of antibiotics, acidifiers, and probiotic supplementation finding good alternative reduce use antibiotics in broiler production rural areas Bangladesh. Using randomized control trial, this 28-day study evaluated 360 Hubbard Classic chicks divided into four groups: oxytetracycline-treated, acidifier-treated, Lactobacillus-based probiotic-treated, (no or probiotics). Each group was replicated three times with 30 birds each adlibitum feeding. Body weight feed intake were recorded weekly, on 28th day, carcass traits blood lipoprotein levels evaluated. Results showed that first fourth weeks, body gain significantly varied probiotics acidifier-treated than (P < 0.001). The had gained considerable increase (185.0g vs 161.7g 1745.0g 1592.7g) group. Notably, week, conversion ratio for 0.76, but antibiotic group's 0.96 weights drumstick (88.33g) liver (61.0g) having supplements substantially higher those (77.0g 51.33g, respectively) According serum analysis, acidifier groups exhibited lower LDL (71.1 mg/dl 69.8 mg/dl, triglyceride (122.9 135.4 mg/dl). These findings highlight potential acidifiers as effective alternatives, promoting lowering broilers

Language: Английский

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Stress as a Catalyst: Understanding its Role in Bowel Cancer

Published: March 26, 2024

Stress has been identified as a prominent contributor to the development and advancement of bowel cancer, however its specific involvement is intricate diverse. This abstract tries offer concise summary correlation between stress consolidating significant discoveries from several research fields. The investigation commences by studying molecular pathways which chronic impacts colon cancer. Chronic causes disruption in functioning neuroendocrine, immunological, inflammatory pathways, leading microenvironment within gastrointestinal system that promotes growth tumours. Furthermore, changes composition gut microbiota, variations epigenetics, alterations immune function caused also have role increasing risk advancing Psychological aspects, including how one perceives stress, tactics they use cope with it, level psychosocial support receive, are crucial determining person's susceptibility cancer impacting effectiveness treatment. management therapies, such cognitive-behavioral therapy mindfulness-based reduction, demonstrated potential enhancing patient well-being promoting adherence Moreover, epidemiological studies clinical trials vital knowledge regarding risk, prognosis, treatment results Although evidence inconclusive, it essential continue researching relationship will help us understand connection better create strategies reduce impact on outcomes.

Language: Английский

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Impact of synbiotics on disease activity in systemic lupus erythematosus: Results from a randomized clinical trial

Journal of Food Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease that affects various organs in the body. In SLE, inflammatory cytokines play a crucial role initiating and sustaining process. Synbiotics may help modulate these cytokines. This randomized, double‐blind, placebo‐controlled clinical trial aimed to assess impact of synbiotics intervention on interleukin‐17A (IL‐17A) levels, activity, factors patients with SLE. Fifty SLE were randomly assigned receive either standard therapy plus (consisting Streptococcus thermophilus , Lactobacillus acidophilus casei rhamnosus salivarius reuteri Bifidobacterium lactis longum bifidum prebiotic fructooligosaccharides) or alone for 2 months. The results demonstrated significant reduction both protein mRNA levels IL‐17A, as well Lupus Erythematosus Disease Activity Index 2000 score, within group after compared baseline. contrast, placebo did not experience changes IL‐17A activity. Synbiotic supplementation shows potential adjunctive therapeutic approach management; however, further research needed elucidate its underlying mechanisms. Practical Application study explores use supplementary treatment systemic erythematosus, which typically managed immunosuppressive therapies.

Language: Английский

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Probiotics in the Treatment of Gastrointestinal Disorders and What We Know About Their Effect on Microbiota

Published: Aug. 21, 2023

Modulating the gut microbiota with probiotics has been identified as a promising therapeutic method for management of gastrointestinal illnesses. The effectiveness in treatment disorders can only be determined by delving into their underlying mechanisms action. Through an analysis processes, this study hopes to provide light on potential benefits treating variety conditions. covers wide conditions, such IBS, IBD, and antibiotic-associated diarrhea. Modifying composition, strengthening barrier function, modulating immune system, producing beneficial metabolites are among action that have investigated. strain- dose-specific variables essential getting best results also highlighted. This review, which synthesizes current information, gives thorough overview illnesses illuminates avenues further use.

Language: Английский

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Probiotics in Cancer Treatment: From the Laboratory to Clinical Practice

Published: July 10, 2023

Probiotics are now being looked at as a possible addition to cancer treatments in both study and clinical settings. This tries give an overview of probiotic research it relates cancer, with focus on how might help avoid treat it, improve the health patients. We look developmental studies that use cell culture animal models well probiotics work cancer. change immune system, inflammation, gut bacteria. The results add-on therapy for patients see they affected treatment success, side effects, quality life benefits certain types such colorectal breast stomach tumors. also find best strains each type synergistic combining standard like chemotherapy, radiation therapy, immunotherapy effectiveness lower effects. Lastly, we talk about present problems future directions personalized methods, ideal doses plans, finding signs making probiotic-based therapies. By learning more could be used can create personalized, successful, well-tolerated outcomes.

Language: Английский

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Microbiota Modulation: Examining the Effects on Pathogen Colonization and Infection

Published: July 17, 2023

The trillions of bacteria that live in and on our bodies make up the human microbiota, which is a very important part keeping us healthy protecting from pathogenic infections. Dysbiosis when there are changes composition variety microbiota. This can upset delicate balance between host its microbes, making more vulnerable to pathogens. Understanding complicated link microbiota pathogens for coming with effective ways change boost body's defenses against study looks at how modulation affects spread It talks about makeup susceptible you shows protect by it hard grow take over. review also goes into detail protects pathogens, such as through competitive exclusion, production antimicrobial compounds, regulation immune reactions. idea dysbiosis linked shifts. Disruptions easier harder fight off focuses need recover microbial improve host's lower risks caused There talk use probiotics, prebiotics, fecal transplantation (FMT) microbiome. goal these interventions restore diversity function integrity barriers, system's reaction methods could be used body In conclusion, knowing work together way help lot comes specific modulation. Strategies microbes stop taking over people sick. More needs done this area therapeutic approaches fullest extent infectious diseases.

Language: Английский

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