Investigative Ophthalmology & Visual Science,
Journal Year:
2025,
Volume and Issue:
66(5), P. 13 - 13
Published: May 6, 2025
Patients
with
dry
eye
disease
(DED)
often
exhibit
neurological
abnormalities
and
may
even
suffer
from
neuropathic
pain
pain-related
anxiety
or
depression.
The
α-7
nicotinic
acetylcholine
receptor
(α7nAChR)
is
a
pivotal
regulator
in
the
anti-inflammatory
pathway
connecting
nervous
immune
systems,
Here,
we
investigate
potential
of
α7nAChR
agonist
as
novel
treatment
for
DED.
We
induced
DED
model
by
unilateral
excision
extraorbital
lachrymal
gland
C57/BL6
mice.
After
seven
days
treatment,
RNA
sequencing
was
performed
to
identify
differentially
expressed
genes
cornea
lacrimal
(LGE)
Quantitative
polymerase
chain
reaction,
Western
blotting,
flow
cytometry
tests
were
carried
out
elucidate
neuroinflammation
changes
after
activation.
Corneal
nerve
assessed
corneal
esthesiometry
immunofluorescence
staining.
activation
stimulates
involved
immune-mediated
inflammatory
progression
neuroregulation,
inhibits
expression
transient
vanilloid-1,
reinstates
density,
alleviates
anxiety-like
behaviors
associated
severe
Furthermore,
demonstrated
that
restored
abnormality
alleviated
inflammation
response
down-regulating
proportion
CD86+
M1
macrophages
(proinflammatory
phenotypes).
Our
findings
underscore
pioneering
therapeutic
approach
preserving
nerves
balance
controlling
The Ocular Surface,
Journal Year:
2023,
Volume and Issue:
28, P. 213 - 252
Published: April 1, 2023
Eye
strain
when
performing
tasks
reliant
on
a
digital
environment
can
cause
discomfort,
affecting
productivity
and
quality
of
life.
Digital
eye
(the
preferred
terminology)
was
defined
as
"the
development
or
exacerbation
recurrent
ocular
symptoms
and/or
signs
related
specifically
to
device
screen
viewing".
prevalence
up
97%
has
been
reported,
due
no
previously
agreed
definition/diagnostic
criteria
limitations
current
questionnaires
which
fail
differentiate
such
from
those
arising
non-digital
tasks.
Objective
blink
rate
critical
flicker
frequency
changes
are
not
'diagnostic'
nor
validated
sensitive.
The
mechanisms
attributed
surface
disease
mainly
reduced
completeness,
partial/uncorrected
refractive
error
underlying
binocular
vision
anomalies,
together
with
the
cognitive
demand
task
differences
in
position,
size,
brightness
glare
compared
an
equivalent
task.
In
general,
interventions
well
established;
patients
experiencing
should
be
provided
full
correction
for
appropriate
working
distances.
Improving
blinking,
optimizing
work
encouraging
regular
breaks
may
help.
Based
current,
best
evidence,
blue-light
blocking
do
appear
effective
management
strategy.
More
larger
clinical
trials
needed
assess
artificial
tear
effectiveness
relieving
strain,
particularly
comparing
different
constituents;
systematic
review
within
report
identified
use
secretagogues
warm
compress/humidity
goggles/ambient
humidifiers
promising
strategies,
along
nutritional
supplementation
(such
omega-3
fatty
acid
berry
extracts).
The Ocular Surface,
Journal Year:
2023,
Volume and Issue:
30, P. 240 - 253
Published: Sept. 1, 2023
The
Tear
Film
&
Ocular
Surface
Society
(TFOS)
Workshop
entitled
'A
Lifestyle
Epidemic:
Disease'
was
a
global
initiative
undertaken
to
establish
the
direct
and
indirect
impacts
of
everyday
lifestyle
choices
challenges
on
ocular
surface
health.
This
article
presents
an
executive
summary
evidence-based
conclusions
recommendations
10-part
TFOS
report.
factors
described
within
report
include
contact
lenses,
cosmetics,
digital
environment,
elective
medications
procedures,
environmental
conditions,
challenges,
nutrition,
societal
challenges.
For
each
topic
area,
current
literature
summarized
appraised
in
narrative-style
review
answer
key
topic-specific
question
sought
using
systematic
methodology.
published
its
entirety
April
2023
July
issues
journal.
Links
downloadable
versions
document
supplementary
material,
including
translations,
are
available
website:
http://www.TearFilm.org.
Progress in Retinal and Eye Research,
Journal Year:
2024,
Volume and Issue:
100, P. 101250 - 101250
Published: March 8, 2024
Changes
in
the
bacterial
flora
gut,
also
described
as
gut
microbiota,
are
readily
acknowledged
to
be
associated
with
several
systemic
diseases,
especially
those
an
inflammatory,
neuronal,
psychological
or
hormonal
factor
involved
pathogenesis
and/or
perception
of
disease.
Maintaining
ocular
surface
homeostasis
is
based
on
all
these
four
factors,
and
there
accumulating
evidence
literature
relationship
between
microbiota
diseases.
The
mechanisms
mostly
interconnected
due
interaction
central
peripheral
neuronal
networks,
inflammatory
effectors
system.
A
better
understanding
influence
maintenance
homeostasis,
onset
persistence
disorders
could
bring
new
insights
help
elucidate
epidemiology
pathology
dynamics
health
Revealing
exact
nature
associations
paramount
importance
for
developing
a
holistic
approach
using
highly
promising
therapeutic
strategies
targeting
The Ocular Surface,
Journal Year:
2023,
Volume and Issue:
31, P. 11 - 20
Published: Dec. 7, 2023
Dry
eye
disease
(DED),
a
multifactorial
ocular
that
significantly
impacts
quality
of
life,
is
most
commonly
reported
in
adults.
This
review
describes
the
prevalence,
risk
factors,
diagnosis
and
management
DED
children.
A
literature
search,
conducted
from
January
2000-December
2022,
identified
54
relevant
publications.
Using
similar
diagnostic
criteria
to
those
adults,
namely
standardized
questionnaires
evaluation
tear
film
homeostatic
signs,
prevalence
children
ranged
5.5%
23.1
%.
There
was
limited
evidence
for
influence
ethnicity
children,
however
some
studies
an
effect
sex
older
Factors
independently
associated
with
included
digital
device
use,
duration
outdoor
time
urban
living,
Rates
were
higher
allergy
underlying
systemic
diseases.
Compared
prior
or
based
on
signs
symptoms
lower
but
reported.
Treatment
options
including
lifestyle
modifications,
blinking,
lid
unpreserved
lubricants
mild
escalating
treatment
severity.
Management
requires
careful
exploration
symptoms,
medical
history
comorbidities
such
as
anterior
blepharitis.
Appropriately
powered
population-based
are
required
understand
factors
Development
age-appropriate
thresholds
would
support
better
understanding
natural
history.
