The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections

European Journal of Clinical Investigation, Journal Year: 2021, Volume and Issue: 52(4)

Published: Oct. 26, 2021

Aortic aneurysms (AA) are pathological dilations of the aorta, associated with an overall mortality rate up to 90% in case rupture. In addition dilation, aortic layers can separate by a tear within layers, defined as dissections (AD). Vascular smooth muscle cells (vSMC) predominant cell type wall and dysregulation vSMC functions contributes AA AD development progression. However, since exact underlying mechanism is poorly understood, finding potential therapeutic targets for challenging surgery remains only treatment option.In this review, we summarize current knowledge about give overview how altered pathogenesis, organized per anatomical location (abdominal or thoracic aorta).Important healthy diseased conditions apoptosis, phenotypic switch, extracellular matrix regeneration degradation, proliferation contractility. Stressors wall, including inflammatory infiltration (epi)genetic changes, modulate cause disturbance processes vSMC, such changes TGF-β signalling regulatory RNA expression.This review underscores central role dysfunction abdominal Further research focused on necessary find noninvasive options.

Language: Английский

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Application of omics in the diagnosis, prognosis, and treatment of acute myeloid leukemia

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: June 10, 2024

Acute myeloid leukemia (AML) is the most frequent in adults with a high mortality rate. Current diagnostic criteria and selections of therapeutic strategies are generally based on gene mutations cytogenetic abnormalities. Chemotherapy, targeted therapies, hematopoietic stem cell transplantation (HSCT) major for AML. Two dilemmas clinical management AML related to its poor prognosis. One inaccurate risk stratification at diagnosis, leading incorrect treatment selections. The other resistance chemotherapy and/or therapies. Genomic features have been focus studies. However, DNA-level aberrations do not always predict expression levels genes proteins latter more closely linked disease phenotypes. With development high-throughput sequencing mass spectrometry technologies, studying downstream effectors including RNA, proteins, metabolites becomes possible. Transcriptomics can reveal regulatory networks, proteomics discover protein signaling pathways intimately associated disease, metabolomics reflect precise changes during progression. Moreover, omics profiling single-cell level enables cellular components hierarchies microenvironment. abundance data from different layers better by identifying prognosis-related biomarkers, has prospective application drug targets, therefore potentially discovering solutions two dilemmas. In this review, we summarize existing studies using methods, both separately combined, covering research fields stratification, prognosis prediction, chemotherapy, as well therapy. Finally, discuss directions challenges multi-omics precision medicine Our review may inspire researchers physicians study angle.

Language: Английский

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Circular RNAs in cardiovascular diseases

Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 232, P. 107991 - 107991

Published: Sept. 27, 2021

Language: Английский

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Circular RNAs as Competing Endogenous RNAs in Cardiovascular and Cerebrovascular Diseases: Molecular Mechanisms and Clinical Implications

Frontiers in Cardiovascular Medicine, Journal Year: 2021, Volume and Issue: 8

Published: July 7, 2021

Circular RNAs (circRNAs) represent a novel class of widespread and diverse endogenous RNA molecules. This unusual species is generated by back-splicing event exons or introns, resulting in covalently closed circRNA molecule. Accumulating evidence indicates that plays an important role the biological functions network competing (ceRNA). CircRNAs can competitively bind to miRNAs abolish suppressive effect on target RNAs, thus regulating gene expression at posttranscriptional level. The circRNAs as ceRNAs pathogenesis cardiovascular cerebrovascular diseases (CVDs) has been recently reported highlighted. Understanding underlying molecular mechanism could aid discovery therapeutic targets strategies against CVDs. Here, we review progress studying CVDs, with emphasis mechanism, discuss future directions possible clinical implications.

Language: Английский

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Circular RNAs as a Diagnostic and Therapeutic Target in Cardiovascular Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2125 - 2125

Published: Jan. 21, 2023

Circular RNAs (circRNAs) are a family of noncoding (ncRNAs) that endogenous and widely distributed in different species, performing several functions, mainly their association with microRNAs (miRNAs) RNA-binding proteins. CVDs remain the leading cause death worldwide; therefore, development new therapies strategies, such as gene or nonpharmacological therapies, low cost, physical exercise, to alleviate these diseases is extreme importance for society. With increasing evidence ncRNA participating progression CVDs, studies have reported promising targets diagnosis treatment. There role miRNAs lncRNAs; however, little known about class RNAs, called circRNAs, CVDs. In this mini review, we focus on mechanisms circRNAs

Language: Английский

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m6A-dependent mature miR-151-5p accelerates the malignant process of HNSCC by targeting LYPD3

Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)

Published: July 16, 2024

miRNA has emerged as a crucial regulator in various of pathological and physiological processes, yet its precise mechanism action the detailed their Head neck squamous cell carcinoma (HNSCC) remains incompletely understood. This study sheds light on role mi-151-5p, revealing significantly elevated expression tumor cells, which notably enhances invasion migration HNSCC cells. effect is achieved through directly targeting LY6/PLAUR Domain Containing 3 (LYPD3) by miR-151-5p, involving complementary binding to 3'-untranslated regions (3'-UTR) mRNA LYPD3. Consequently, this interaction accelerates metastasis HNSCC. Notably, clinical observations indicate correlation between high miR-151-5p low levels LYPD3 settings are correlated with poor prognosis patients. Furthermore, our investigation demonstrates that glycosylation modulates subcellular localization reinforces suppressing metastasis. Additionally, we uncover potential regulatory facilitation maturation accumulation N6-methyladenosine (m6A) modification. process orchestrated methyltransferase-like (METTL3) mediated newly identified reader, heterogeneous nuclear ribonucleoprotein U (hnRNP U). These findings collectively underscore significance METTL3/miR-151-5p/LYPD3 axis serves prominent driver malignant progression

Language: Английский

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The Function and Therapeutic Potential of Circular RNA in Cardiovascular Diseases

Cardiovascular Drugs and Therapy, Journal Year: 2021, Volume and Issue: 37(1), P. 181 - 198

Published: July 16, 2021

Language: Английский

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Circular RNAs modulate cell death in cardiovascular diseases

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: May 2, 2025

Language: Английский

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Identification of hub genes related to the progression of type 1 diabetes by computational analysis

BMC Endocrine Disorders, Journal Year: 2021, Volume and Issue: 21(1)

Published: April 7, 2021

Abstract Background Type 1 diabetes (T1D) is a serious threat to childhood life and has fairly complicated pathogenesis. Profound attempts have been made enlighten the pathogenesis, but molecular mechanisms of T1D are still not well known. Methods To identify candidate genes in progression T1D, expression profiling by high throughput sequencing dataset GSE123658 was downloaded from Gene Expression Omnibus (GEO) database. The differentially expressed (DEGs) were identified, gene ontology (GO) pathway enrichment analyses performed. protein-protein interaction network (PPI), modules, target - miRNA regulatory TF analysis constructed analyzed using HIPPIE, miRNet, NetworkAnalyst Cytoscape. Finally, validation hub conducted ROC (Receiver operating characteristic) curve RT-PCR analysis. A docking study Results total 284 DEGs consisting 142 up regulated down genes. pathways include cell-cell signaling, vesicle fusion, plasma membrane, signaling receptor activity, lipid binding, GPCR innate immune system. Four identified biological process revealed that these mainly enriched cytokine system, showed EGFR, GRIN2B, GJA1, CAP2, MIF, POLR2A, PRKACA, GABARAP, TLN1 PXN might be involved advancement T1D. Molecular studies score. Conclusions present investigation help us understand underlying provide targets for diagnosis treatment

Language: Английский

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Circ_0008571 modulates the phenotype of vascular smooth muscle cells by targeting miR-145-5p in intracranial aneurysms

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(6), P. 167278 - 167278

Published: June 2, 2024

Language: Английский

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