Analysis of genes associated with Alzheimer's disease and endoplasmic reticulum stress DOI Creative Commons
Ziyu Liu, Fei Li

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 11, 2024

Abstract Objecitve Endoplasmic reticulum (ER) stress can activate the unfolded protein response (UPR), and sustained activation of UPR is closely associated with inflammation neuronal dysfunction, ultimately leading to neurodegeneration. This study aims identify potential targets related ER stress, aiming provide new insights into treatment Alzheimer's disease (AD). Methods We conducted differential expression analysis GSE4757 dataset in Gene Expression Omnibus (GEO) database using GEO2R tool performed Venn differentially expressed genes (DEGs) stress. Subsequently, we annotated functions DEGs genes, constructed a protein-protein interaction network Cytoscape, identified hub genes. Results The contained total 407 DEGs, 33 overlapping those The biological processes involved these mainly include mesenchymal morphogenesis, muscle growth, ossification regulation. KEGG revealed that participate cellular pathways such as basal cell carcinoma signaling pathway, breast cancer, pertussis pathway. We also four AD by Cytoscape. Conclusion used bioinformatics role AD, analyzed their involvement processes, for intervening thereby providing direction treating AD.

Language: Английский

Molecular mechanism of ATF6 in unfolded protein response and its role in disease DOI Creative Commons
Yingying Lei, Hong Yu, Shaoxue Ding

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e25937 - e25937

Published: Feb. 10, 2024

Activating transcription factor 6 (ATF6), an important signaling molecule in unfolded protein response (UPR), plays a role the pathogenesis of several diseases, including diseases such as congenital retinal disease, liver fibrosis and ankylosing spondylitis. After endoplasmic reticulum stress (ERS), ATF6 is activated after separation from binding immunoglobulin (GRP78/BiP) (ER) transported to Golgi apparatus be hydrolyzed by site 1 2 proteases into fragments, which localize nucleus regulate expression ERS-related genes. In these ERS leads activation UPR, ultimately lead occurrence development regulating physiological state cells through pathway. Here, we discuss evidence for pathogenic importance different preclinical results.

Language: Английский

Citations

28
Advancements in autophagy perturbations in Alzheimer’s disease: Molecular aspects and therapeutics DOI

Rishika Dhapola,

Sneha Kumari,

Prajjwal Sharma

et al.

Brain Research, Journal Year: 2025, Volume and Issue: 1851, P. 149494 - 149494

Published: Feb. 6, 2025

Language: Английский

Citations

1
The Interplay Between Endoplasmic Reticulum Stress and Ferroptosis in Neurological Diseases DOI

Tianyu Zhai,

Bingbing Wang,

Caizhen Shi

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: Feb. 10, 2025

Language: Английский

Citations

1
Insight into the pathophysiological advances and molecular mechanisms underlying cerebral stroke: current status DOI

Rishika Dhapola,

Bikash Medhi,

Dibbanti HariKrishnaReddy

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: May 11, 2024

Language: Английский

Citations

6
Insight into the emerging and common experimental in-vivo models of Alzheimer’s disease DOI Creative Commons

Rishika Dhapola,

Sneha Kumari,

Prajjwal Sharma

et al.

Laboratory Animal Research, Journal Year: 2023, Volume and Issue: 39(1)

Published: Dec. 11, 2023

Abstract Alzheimer’s disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder. As the exact cause of still unclear, drug development very challenging. This review encompasses commonly used AD models involving various chemicals, heavy metals and endogenous substances induced transgenic models. It also provides insight into reliable emerging that may overcome shortcomings associated with available Chemicals like streptozotocin, scopolamine, colchicine okadaic acid render animal susceptible to neuroinflammation oxidative stress neurodegeneration along amyloid-β deposition tau hyperphosphorylation. Similarly, acrolein 1–42 are efficient in inducing major pathologies AD. Heavy aluminum fluoride mixture these have been reported induce neurotoxicity therefore as for Transgenic developed result knock-in or knock-out certain genes including PDAPP, APP23, Tg2576, APP/PS1, 3 × Tg 5 FAD incorporated this study. Further, advanced pathomimetic provided particular interest here which will add on current knowledge aid process deepen our understanding related pathogenesis. These newly discovered include oAβ25-35 model, model expressing 82-kDa ChAT, oDGal mouse APP rat. study selection suitable novel potent therapeutics exploring detailed pathogenic mechanism Graphical abstract

Language: Английский

Citations

14
Endoplasmic reticulum stress and unfolded protein response in renal lipid metabolism DOI
Xinyi Zhou, Ziyi Li,

Fajian Ren

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114463 - 114463

Published: Feb. 1, 2025

Language: Английский

Citations

0
Recent Progress in Nanomedicine for the Diagnosis and Treatment of Alzheimer’s Diseases DOI

Han Yang,

Haozhe Tan,

Haifei Wen

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(50), P. 33792 - 33826

Published: Dec. 3, 2024

Alzheimer's disease (AD) is a neurodegenerative that causes memory loss and progressive permanent deterioration of cognitive function. The most challenging issue in combating AD its complicated pathogenesis, which includes the deposition amyloid β (Aβ) plaques, intracellular hyperphosphorylated tau protein, neurofibrillary tangles (NFT), etc. Despite rapid advancements mechanistic research drug development for AD, currently developed drugs only improve ability temporarily relieve symptoms but cannot prevent AD. Moreover, blood–brain barrier (BBB) creates huge to delivery brain. Therefore, effective diagnostic tools treatments are urgently needed. In recent years, nanomedicine has provided opportunities overcome challenges limitations associated with traditional diagnostics or treatments. Various types nanoparticles (NPs) play an essential role diagnosis treatment acting as carriers targeting bioavailability across/bypass BBB directly on lesions. This review categorizes different NPs summarizes their applications It also discusses clinical explores latest developments prospects

Language: Английский

Citations

4
A Structural Effect of the Antioxidant Curcuminoids on the Aβ(1–42) Amyloid Peptide DOI Creative Commons
Angelo Santoro, Antônio Ricci, Manuela Rodriquez

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 53 - 53

Published: Jan. 5, 2025

Investigating amyloid-β (Aβ) peptides in solution is essential during the initial stages of developing lead compounds that can influence Aβ fibrillation while peptide still a soluble state. The tendency Aβ(1-42) to misfold solution, correlated aetiology Alzheimer's disease (AD), one main hindrances characterising its aggregation kinetics cell-mimetic environment. Moreover, triggers unfolded protein response (UPR) endoplasmic reticulum (ER), leading cellular dysfunction and multiple cell death modalities, exacerbated by reactive oxygen species (ROS), which damage components trigger inflammation. Antioxidants like curcumin, derivative Curcuma longa, help mitigate ER stress scavenging ROS enhancing antioxidant enzymes. Furthermore, evidence literature highlights effect curcumin on secondary structure Aβ(1-42). This explorative study investigates conformational behaviour presence six derivatives using circular dichroism (CD) explore their interactions with lipid bilayers, potentially preventing aggregate formation. results suggest synthetic tetrahydrocurcumin (THC) interacts amyloid all systems presented, cyclocurcumin (CYC) bisdemethoxycurcumin (BMDC) only interact when less stable conformation. Molecular dynamics simulations helped visualise curcuminoids' an aqueous system hypothesise importance surface exposition solvent, differently modulated derivatives.

Language: Английский

Citations

0
Facile synthesis of the unknown 6,7-dihydrofuro[3,4-c]pyridines and 3,4-diaryloylpyridines from N-propargyl β-enaminones DOI Creative Commons
Elif Serel Yilmaz, Kerem Kaya, Metin Zora

et al.

Organic & Biomolecular Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A simple methodology for the synthesis of bicyclic 6,7-dihydrofuro[3,4- c ]pyridines is reported. The skeletal diversity synthesized heterobicyclic frame may present new nitrogen- and oxygen-based hybrid systems medicinal chemistry.

Language: Английский

Citations

0
Okra seed polysaccharides mitigate neuroinflammation and cognitive impairment via modulation of Nrf2/HO-1, HMGB1/RAGE/TLR4/NF-κB, NLRP3/Caspase-1, JAK-2/STAT-3, AMPK/SIRT1/m-TOR, PI3K/AKT/CREB/BDNF/TrkB and PERK/CHOP/Bcl-2 axes DOI
Jilan A. Nazeam, Ian Black,

Varughese A Mulamoottil

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114110 - 114110

Published: Jan. 24, 2025

Language: Английский

Citations

0