Acetyl-CoA carboxylase as potential molecular target of dimethyl trisulfide on inhibiting the Aspergillus flavus growth and aflatoxins production DOI Creative Commons
An‐Dong Gong,

Mengge Song,

Jingrong Liu

et al.

LWT, Journal Year: 2024, Volume and Issue: 198, P. 115924 - 115924

Published: March 3, 2024

Aspergillus flavus and the produced aflatoxins are common hazardous contaminants in grains food, which generated great damage to food security human health. Acetyl-CoA carboxylase (ACC), catalyzing acetyl-CoA malonyl-CoA, is first speed-determining step fatty acid biosynthesis (cell membrane composition) process A. flavus. Here, we demonstrated that dimethyl trisulfide (DMTS), emitted from bacteria, could interact with ACC, decrease enzymatic activity 377.62 191.42 kat/g vitro, down-regulate expression of ACC other important genes aflatoxin pathway, reduce content hexadecanoic acid, octadecanoic eicosanoic finally prevent growth production. Two binding sites containing 19 amino acids were detected between DMTS through molecular docking analysis. These highly conserved different filamentous fungi, accounted for broad antifungal spectrum DMTS. Therefore, concluded target on results elucidate inhibitory mechanism fungal pathogens, provide basic theories development novel agents.

Language: Английский

Synergistic antifungal mechanism of eugenol and citral against Aspergillus niger: Molecular Level DOI
Xiaobin Wang, Qingli Yang, Fangyuan Zhao

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 213, P. 118435 - 118435

Published: March 27, 2024

Language: Английский

Citations

39

Antifungal mechanism of Angelica sinensis essential oil against Penicillium roqueforti and its application in extending the shelf life of bread DOI

Qingchao Gao,

Jingjing Qi, Yulong Tan

et al.

International Journal of Food Microbiology, Journal Year: 2023, Volume and Issue: 408, P. 110427 - 110427

Published: Oct. 6, 2023

Language: Английский

Citations

43

Trans-2-hexenal inhibits the growth of imazalil-resistant Penicillium digitatum Pdw03 and delays green mold in postharvest citrus DOI
Xingxing Yuan,

Kuixian Meng,

Shiwei Shi

et al.

Postharvest Biology and Technology, Journal Year: 2023, Volume and Issue: 199, P. 112304 - 112304

Published: Feb. 22, 2023

Language: Английский

Citations

25

Antifungal effects of carvacrol, the main volatile compound in Origanum vulgare L. essential oil, against Aspergillus flavus in postharvest wheat DOI

Wen-Yan Duan,

Xi-Man Zhu,

Shuaibing Zhang

et al.

International Journal of Food Microbiology, Journal Year: 2023, Volume and Issue: 410, P. 110514 - 110514

Published: Dec. 5, 2023

Language: Английский

Citations

25

Antifungal activity of selected lactic acid bacteria from olive drupes DOI Creative Commons
Mario Riolo, Carlos Luz, Elena Santilli

et al.

Food Bioscience, Journal Year: 2023, Volume and Issue: 52, P. 102422 - 102422

Published: Jan. 27, 2023

In this study, 16 Lactobacilli (LABs) isolated from the drupes of olive (Olea europaea) oil varieties were identified as Lactiplantibacillus plantarum (seven isolates), Pediococcus pentosaceus (six Enterococcus faecium (two isolates) and Streptococcus salivarius (a single isolate) by peptide mass fingerprinting sequencing 16S rRNA. Antifungal activity LABs their cell-free fermentates (CFSs) against several plant pathogenic fungi oomycetes (fungi sensu lato), including Alternaria, Aspergillus Colletotrichum, Penicillium, Plenodomus Phytophthora, was evaluated in vitro using culture overlaying agar diffusion tests. Minimal inhibitory concentration (MIC) minimal fungicidal (MFC) determined. showed antifungal lato tested. The most noticeable shown isolates L. P. Fusarium oxysporum, Colletotrichum species Penicillium nordicum. Chemical analysis revealed CFSs contained acid lactic variable quantities 14 diverse phenolic acids 26 volatile organic compounds (VOCs). No obvious correlation found between metabolic profile efficacy. However, it is first time that potential LABs, recovered varieties, natural fungicides, demonstrated.

Language: Английский

Citations

23

Curcumin inhibits Aspergillus flavus infection and aflatoxin production possibly by inducing ROS burst DOI
Danfeng Zhang,

Youyang Yang,

Bangben Yao

et al.

Food Research International, Journal Year: 2023, Volume and Issue: 167, P. 112646 - 112646

Published: Feb. 26, 2023

Language: Английский

Citations

20

Synergistic antifungal mechanism of cinnamaldehyde and nonanal against Aspergillus flavus and its application in food preservation DOI
Wei Zhang,

Cuixiang Li,

Yangyong Lv

et al.

Food Microbiology, Journal Year: 2024, Volume and Issue: 121, P. 104524 - 104524

Published: March 25, 2024

Language: Английский

Citations

8

The Role of Oxidative Stress in the Antifungal Activity of Two Mollusk Fractions on Resistant Fungal Strains DOI Open Access
Lyudmila Velkova,

Radoslav Abrashev,

Jeny Miteva‐Staleva

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 985 - 985

Published: Jan. 24, 2025

Fungal infections are a significant global public health challenge because of their widespread occurrence, morbidity, and profound social economic consequences. Antifungal resistance is also an increasing concern, posing substantial risk to health. There growing interest in searching for new antifungal drugs isolated from natural sources. This study aimed evaluate the activity novel mollusk fractions against fungal strains resistant nystatin amphotericin B. In addition, role oxidative stress mechanism damage was determined. The mucus garden snail Cornu aspersum (MCa/1-20) hemolymph fraction marine Rapana venosa (HLRv/3-100) were obtained characterized via 12% sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) mass spectrometric -analyses. results demonstrate that spores biomass both have fungicidal effect Penicillium griseofulvum, Aspergillus niger. Compared control group, release intracellular proteins reducing sugars significantly increased treated groups. data showed levels biomarkers (lipid peroxidation oxidatively damaged proteins) downregulated antioxidant enzyme defense, corresponding activity. To our knowledge, this first evaluating as factor fractions’

Language: Английский

Citations

1

Inhibition Mechanism of Cinnamomum burmannii Leaf Essential Oil Against Aspergillus flavus and Aflatoxins DOI Creative Commons

Huanyan Liang,

Feifei Lv,

Xian Mu

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(4), P. 682 - 682

Published: Feb. 17, 2025

This investigation evaluates the comparative efficacy of Cinnamomum burmannii leaf essential oil (YXYO) and its main active ingredients as a novel preservative to protect stored food commodities from fungal infestations, aflatoxin B1 (AFB1) contamination caused by Aspergillus flavus. Morphological observations utilizing SEM TEM revealed significant alterations in treated samples, alongside decrease ergosterol content dose-dependent disruption antioxidant system energy system. Transcriptomic analysis suggested that differentially expressed genes were predominantly associated with spore growth, cell wall, membrane, oxidative stress, metabolism, biosynthesis. Solid-phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS) identified ten YXYO, including borneol, α-terpineol, terpinen-4-ol, etc. Moreover, an effective inhibition A. flavus infection peanuts was observed application 30 μL/disc YXYO blend compounds.

Language: Английский

Citations

1

Antifungal and elicitor activities of p-hydroxybenzoic acid for the control of aflatoxigenic Aspergillus flavus in kiwifruit DOI

Zi-Yao Huo,

Xin‐Chi Shi,

Yanxia Wang

et al.

Food Research International, Journal Year: 2023, Volume and Issue: 173, P. 113331 - 113331

Published: July 28, 2023

Language: Английский

Citations

17