Protein & Cell,
Journal Year:
2015,
Volume and Issue:
6(5), P. 334 - 350
Published: March 23, 2015
Transporters
comprise
the
largest
family
of
membrane
proteins
in
human
organism,
including
members
solute
carrier
transporter
and
ATP-binding
cassette
families.
They
play
pivotal
roles
absorption,
distribution
excretion
xenobiotic
endogenous
molecules.
are
widely
expressed
various
tissues
routinely
evaluated
during
process
drug
development
approval.
Over
past
decade,
increasing
evidence
shows
that
transporters
important
both
normal
physiology
disease.
Currently,
utilized
as
therapeutic
targets
to
treat
numerous
diseases
such
diabetes,
major
depression,
hypertension
constipation.
Despite
steady
growth
field
biology,
more
than
half
superfamily
have
little
information
available
about
their
substrate(s)
or
physiological
functions.
This
review
outlines
current
research
methods
studies,
summarizes
drug-transporter
interactions
drug-drug
drug-endogenous
substrate
interactions.
In
end,
we
also
discuss
perspective
based
on
pathophysiological
roles.
Molecular Aspects of Medicine,
Journal Year:
2013,
Volume and Issue:
34(2-3), P. 95 - 107
Published: March 16, 2013
The
field
of
transport
biology
has
steadily
grown
over
the
past
decade
and
is
now
recognized
as
playing
an
important
role
in
manifestation
treatment
disease.
SLC
(solute
carrier)
gene
series
to
include
52
families
395
transporter
genes
human
genome.
A
list
these
can
be
found
at
HUGO
Gene
Nomenclature
Committee
(HGNC)
website
(see
www.genenames.org/genefamilies/SLC).
This
special
issue
features
mini-reviews
for
each
written
by
experts
field.
existing
online
resource
solute
carriers,
Bioparadigms
Tables
(www.bioparadigms.org),
been
updated
significantly
extended
with
additional
information
cross-links
other
relevant
databases,
nomenclature
used
this
database
validated
approved
HGNC.
In
addition,
functionality
improved
allow
easier
access
scientific
community.
introduction
includes:
overview
all
known
“non-SLC”
genes;
a
transporters
water
soluble
vitamins;
summary
recent
progress
structure
determination
(including
GLUT1/SLC2A1);
roles
diseases
drug
approval
pharmaceutical
perspectives.
Clinical Journal of the American Society of Nephrology,
Journal Year:
2015,
Volume and Issue:
10(12), P. 2232 - 2242
Published: Nov. 24, 2015
Acid-base
homeostasis
and
pH
regulation
are
critical
for
both
normal
physiology
cell
metabolism
function.
The
importance
of
this
is
evidenced
by
a
variety
physiologic
derangements
that
occur
when
plasma
either
high
or
low.
kidneys
have
the
predominant
role
in
regulating
systemic
bicarbonate
concentration
hence,
metabolic
component
acid-base
balance.
This
function
has
two
components:
reabsorption
virtually
all
filtered
HCO3−
production
new
to
replace
consumed
pathologic
acids.
generation
done
net
acid
excretion.
Under
conditions,
approximately
one-third
one-half
excretion
form
titratable
acid.
other
two-thirds
ammonium.
capacity
excrete
ammonium
under
conditions
loads
quantitatively
much
greater
than
increase
Multiple,
often
redundant
pathways
processes
exist
regulate
these
renal
functions.
Derangements
homeostasis,
however,
common
clinical
medicine
can
be
related
systems
involved
transport
kidneys.
Cellular and Molecular Life Sciences,
Journal Year:
2016,
Volume and Issue:
74(1), P. 93 - 115
Published: Oct. 6, 2016
Salt
and
fluid
absorption
secretion
are
two
processes
that
fundamental
to
epithelial
function
whole
body
homeostasis,
as
such
tightly
regulated
in
tissues.
The
CFTR
anion
channel
plays
a
major
role
regulating
both
diverse
range
of
tissues,
including
the
airways,
GI
reproductive
tracts,
sweat
salivary
glands.
It
is
not
surprising
then
defects
linked
disease,
life-threatening
secretory
diarrhoeas,
cholera,
well
inherited
cystic
fibrosis
(CF),
one
most
common
life-limiting
genetic
diseases
Caucasian
populations.
More
recently,
dysfunction
has
also
been
implicated
pathogenesis
acute
pancreatitis,
chronic
obstructive
pulmonary
disease
(COPD),
hyper-responsiveness
asthma,
underscoring
its
health
disease.
regulates
many
mechanisms
physiology,
maintaining
surface
hydration
luminal
pH.
Indeed,
recent
studies
have
identified
pH
an
important
arbiter
barrier
innate
defence,
particularly
airways
tract.
In
this
chapter,
we
will
illustrate
different
operational
roles
by
describing
characteristics
three
tissues:
pancreas,
gland.
FEBS Journal,
Journal Year:
2020,
Volume and Issue:
288(9), P. 2784 - 2835
Published: Aug. 24, 2020
This
review
aims
to
serve
as
an
introduction
the
solute
carrier
proteins
(SLC)
superfamily
of
transporter
and
their
roles
in
human
cells.
The
SLC
currently
includes
458
transport
65
families
that
carry
a
wide
variety
substances
across
cellular
membranes.
While
members
this
are
found
throughout
organelles,
focuses
on
transporters
expressed
at
plasma
membrane.
At
cell
surface,
may
be
viewed
gatekeepers
milieu,
dynamically
responding
different
metabolic
states.
With
altered
metabolism
being
one
hallmarks
cancer,
we
also
briefly
surface
play
development
progression
cancer
through
influence
regulating
environmental
conditions.
Science,
Journal Year:
2018,
Volume and Issue:
359(6372), P. 191 - 199
Published: Jan. 12, 2018
Chemogenetic
characterization
through
in
vitro
evolution
combined
with
whole-genome
analysis
can
identify
antimalarial
drug
targets
and
drug-resistance
genes.
We
performed
a
genome
of
262
Sulfur
is
one
of
the
essential
nutrients
that
required
for
adequate
growth
and
development
plants.
a
structural
component
protein
disulfide
bonds,
amino
acids,
vitamins,
cofactors.
Most
sulfur
in
soil
present
organic
matter
hence
not
accessible
to
Anionic
form
(SO42−)
primary
source
plants
are
generally
minimal
amounts
soil.
It
water-soluble,
so
readily
leaches
out
sulfur-containing
compounds
act
as
signaling
molecules
stress
management
well
normal
metabolic
processes.
They
also
take
part
crosstalk
complex
network
mediator
molecule.
Plants
uptake
sulfate
directly
from
by
using
their
dedicated
transporters.
In
addition,
use
transporter
symbiotically
associated
organism
like
bacteria
fungi
especially
under
depleted
conditions.
So,
very
important
plant
metabolism
its
analysis
with
different
dimensions
highly
improve
overall
well-being
plants,
dependent
animals
human
beings.
The
deficiency
leads
stunted
ultimately
loss
yield.
this
review,
we
have
focused
on
nutrition,
uptake,
transport,
inter-organismic
transfer
host
Given
strong
potential
agricultural
sources
applications,
cover
what
known
about
impact
health.
We
identify
opportunities
expand
our
understanding
how
application
microbes
AMF
or
other
root
endophytic
affects
turn
development.
Microbiology and Molecular Biology Reviews,
Journal Year:
2016,
Volume and Issue:
80(1), P. 205 - 327
Published: March 1, 2016
SUMMARY
The
genus
Trichoderma
contains
fungi
with
high
relevance
for
humans,
applications
in
enzyme
production
plant
cell
wall
degradation
and
use
biocontrol.
Here,
we
provide
a
broad,
comprehensive
overview
of
the
genomic
content
these
species
“hot
topic”
research
aspects,
including
CAZymes,
transport,
transcription
factors,
development,
along
detailed
analysis
annotation
less-studied
topics,
such
as
signal
transduction,
genome
integrity,
chromatin,
photobiology,
or
lipid,
sulfur,
nitrogen
metabolism
T.
reesei
,
atroviride
virens
open
up
new
perspectives
to
those
topics
discussed
previously.
In
total,
covered
more
than
2,000
predicted
9,000
11,000
genes
each
discussed,
which
is
>20%
respective
gene
content.
Additionally,
considered
available
transcriptome
data
annotated
genes.
Highlights
our
analyses
include
overall
carbohydrate
cleavage
preferences
due
different
contents
regulation
We
found
light
many
sulfur
metabolic
Golgi
1,2-mannosidase
likely
involved
N
-linked
glycosylation
was
detected,
were
indications
ability
spp.
generate
hybrid
galactose-containing
glycans.
inventory
effector
proteins
revealed
numerous
compounds
unique
warrant
further
investigation.
interesting
expansions
several
signaling
pathways,
G-protein-coupled
receptors,
RAS
GTPases,
casein
kinases.
A
particularly
feature
absolutely
duplication
alternative
amino
acid
synthesis
pathway.
