The Love Hormone and Seizure Control: A Review of Oxytocin’s Impact on Epilepsy Management DOI Creative Commons
Lufuno Makhado, Thendo Gertie Makhado

IntechOpen eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 3, 2023

Epilepsy is a neurological disorder characterised by recurrent seizures, which can significantly impact patient’s quality of life. While current management strategies for epilepsy, such as antiepileptic drugs and surgery, are effective many patients, there need novel therapies that provide better seizure control improve patients’ outcomes. Oxytocin, neuropeptide known its role in social bonding trust, has emerged promising therapy epilepsy. Preclinical studies have shown oxytocin reduce activity outcomes animal models In contrast, clinical suggested may frequency severity some epilepsy patients. This chapter reviews the knowledge including potential mechanisms oxytocin’s effects, limitations challenges studies, future research directions implications. The also discusses broader on understanding behaviour disorders. Overall, highlights underscores further research.

Language: Английский

Leaving no patient behind! Expert recommendation in the use of innovative technologies for diagnosing rare diseases DOI Creative Commons
Clara D.M. van Karnebeek, Anne O’Donnell‐Luria, Gareth Baynam

et al.

Orphanet Journal of Rare Diseases, Journal Year: 2024, Volume and Issue: 19(1)

Published: Sept. 27, 2024

Language: Английский

Citations

4
Personalised Medicine and Molecular Docking: Tailoring Drug Discovery for Individual Patients DOI Creative Commons
Noopur Khare,

Pragati Khare

Biomedical engineering, Journal Year: 2024, Volume and Issue: unknown

Published: April 29, 2024

The combination of molecular docking with personalised medicine represents a paradigm shift in drug development, providing unmatched accuracy customising therapeutic approaches for specific patients. This collaborative effort utilises cutting-edge computational methods, including docking, conjunction genetic insights to optimise and anticipate drug-receptor interactions. Revolutionary achievements could be further amplified by integrating large-scale omics data, artificial intelligence, structural biology discoveries. Molecular are developing fields that lead treatments take into account each patient’s unique profile addition previously unheard-of levels disease diagnosis. revolutionary landscape will enhanced future developments quantum computing, CRISPR-based gene editing, biomarker discovery. These advances enable the realisation healthcare which interventions not only precise but also proactive, thereby realising full potential customised strategies improved patient outcomes.

Language: Английский

Citations

3
In vivo antibacterial activity of medicinal plant Sophora flavescens against Streptococcus agalactiae infection DOI
Fa‐Li Zhang, Yang Liu,

Wei‐Hao He

et al.

Journal of Fish Diseases, Journal Year: 2023, Volume and Issue: 46(9), P. 977 - 986

Published: June 9, 2023

Streptococcosis disease caused by Streptococcus agalactiae (Group B Streptococcus, GBS) results in a huge economic loss of tilapia culture. It is urgent to find new antimicrobial agents against streptococcosis. In this study, 20 medicinal plants were evaluated vitro and vivo obtain potential bioactive compounds GBS infection. The showed that the ethanol extracts had low or no antibacterial properties vitro, with minimal inhibitory concentration ≥256 mg/L. Interestingly, tests 7 could significantly inhibit infection tilapia, Sophora flavescens (SF) strongest anti-GBS activity reaching 92.68%. SF reduce bacterial loads different tissues (liver, spleen brain) after treated tested concentrations (12.5, 25.0, 50.0 100.0 mg/kg) for 24 h. Moreover, 50 mg/kg improve survival rate GBS-infected inhibiting replication. Furthermore, expression antioxidant gene cat, immune-related c-type lysozyme anti-inflammatory cytokine il-10 liver tissue increased Meanwhile, reduced myd88 pro-inflammatory cytokines il-8 il-1β tilapia. negative positive models UPLC-QE-MS, respectively, identified 27 57 components SF. major extract model α, α-trehalose, DL-malic acid, D- (-)-fructose xanthohumol, while oxymatrine, formononetin, (-)-maackiain xanthohumol. oxymatrine xanthohumol Taken together, these suggest can it has development agents.

Language: Английский

Citations

8
Emerging technologies in personalized medicine DOI

Christopher E. Hopkins

Molecular Aspects of Medicine, Journal Year: 2023, Volume and Issue: 91, P. 101182 - 101182

Published: Feb. 16, 2023

Language: Английский

Citations

4
Clinical variants in Caenorhabditis elegans expressing human STXBP1 reveal a novel class of pathogenic variants and classify variants of uncertain significance DOI Creative Commons

Christopher E. Hopkins,

Kathryn McCormick,

Trisha Brock

et al.

Genetics in Medicine Open, Journal Year: 2023, Volume and Issue: 1(1), P. 100823 - 100823

Published: Jan. 1, 2023

Language: Английский

Citations

3
A humanized Caenorhabditis elegans model of hereditary spastic paraplegia-associated variants in KLC4 DOI Creative Commons

Selin Gümüşderelioğlu,

Lauren Resch,

Trisha Brock

et al.

Disease Models & Mechanisms, Journal Year: 2023, Volume and Issue: 16(8)

Published: Aug. 1, 2023

ABSTRACT Hereditary spastic paraplegia (HSP) is a group of degenerative neurological disorders. We identified variant in human kinesin light chain 4 (KLC4) that suspected to be associated with autosomal-dominant HSP. How this and other variants relate pathologies unknown. created humanized Caenorhabditis elegans model which klc-2 was replaced by KLC4 (referred as hKLC4) assessed the extent hKLC4 retained function worm. observed slight decrease motility but no nuclear migration defects worms, suggesting retains much klc-2. Five were introduced into model. The clinical led early lethality, significant when homozygous weak defect heterozygous, possibly correlating finding late-onset HSP proband heterozygous. Thus, we able establish C. an animal for use it test significance five uncertain gene KLC4.

Language: Английский

Citations

3
Oxytocin and Social Function DOI
Olih Solihin,

Ahmad Zakki Abdullah,

Devi Kurniati

et al.

IntechOpen eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 30, 2023

Welcome to the world of Oxytocin and Social Function, an in-depth exploration powerful role this neuropeptide in shaping our social behaviors interactions. The book delves into rich complex relationship between oxytocin functions. Featuring contributions from leading experts field, offers a comprehensive understanding oxytocin's lives. It goes beyond laboratory explore hormone's potential real-world applications. also highlights recent research on enhancing empathy, reducing stress, promoting overall well-being. With book, readers will gain deeper intricate workings how it shapes relationships. Function is must-read for anyone interested human behavior, psychology, neuroscience, or ever-growing field research. Turn page embark captivating journey hidden potentials its transformative effects function.

Language: Английский

Citations

3
A new Caenorhabditis elegans model to study copper toxicity in Wilson disease DOI Creative Commons
Federico Catalano, Thomas O’Brien, Aleksandra A. Mekhova

et al.

Traffic, Journal Year: 2023, Volume and Issue: 25(1)

Published: Oct. 27, 2023

Abstract Wilson disease (WD) is caused by mutations in the ATP7B gene that encodes a copper (Cu) transporting ATPase whose trafficking from Golgi to endo‐lysosomal compartments drives sequestration of excess Cu and its further excretion hepatocytes into bile. Loss function leads toxic overload liver subsequently brain, causing fatal hepatic neurological abnormalities. The limitations existing WD therapies call for development new therapeutic approaches, which require an amenable animal model system screening validation drugs molecular targets. To achieve this objective, we generated mutant Caenorhabditis elegans strain with substitution conserved histidine (H828Q) ortholog cua‐1 corresponding most common variant (H1069Q) causes WD. animals exhibited very poor resistance compared wild‐type strain. This manifested strong delay larval development, shorter lifespan, impaired motility, oxidative stress pathway activation, mitochondrial damage. In addition, morphological analysis revealed several neuronal abnormalities exposed Cu. Further investigation suggested CUA‐1 retained degraded endoplasmic reticulum, similarly human ATP7B‐H1069Q. As consequence, protein does not allow counteract toxicity. Notably, pharmacological correctors ATP7B‐H1069Q reduced toxicity mutants indicating similar pathogenic pathways might be activated H/Q and, therefore, targeted rescue ATP7B/CUA‐1 function. Taken together, our findings suggest newly represents excellent studies

Language: Английский

Citations

3
A humanizedCaenorhabditis elegansmodel of Hereditary Spastic Paraplegia-associated variants in kinesin light chain KLC4 DOI Creative Commons

Selin Gümüşderelioğlu,

Lauren Resch,

Trisha Brock

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 8, 2023

Hereditary spastic paraplegia (HSP) is a group of degenerative neurological disorders. We identified variant in human kinesin light chain

Language: Английский

Citations

2
CytoSIP: an annotated structural atlas for interactions involving cytokines or cytokine receptors DOI Creative Commons
Lu Wang,

Fang Sun,

Qianying Li

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: May 24, 2024

Abstract Therapeutic agents targeting cytokine-cytokine receptor (CK-CKR) interactions lead to the disruption in cellular signaling and are effective treating many diseases including tumors. However, a lack of universal quick access annotated structural surface regions on CK/CKR has limited progress structure-driven approach developing targeted macromolecular drugs precision medicine therapeutics. Herein we develop CytoSIP (Single nucleotide polymorphisms (SNPs), I nterface, P henotype), rich internet application based database atomic around hotspots experimentally determined complexes. contains: (1) SNPs CK/CKR; (2) involving domains, interfaces, oligomeric epitopes, or other drug surfaces; (3) phenotypes associated with SNPs. The framework introduces unique tri-level SIP data model bridge genetic variants (atomic level) disease (organism using protein structure (complexes) as an underlying (molecule level). Customized screening tools implemented retrieve relevant subset, which reduces time resources needed interrogate large datasets pathologies. portal is publicly accessible at https://CytoSIP.biocloud.top , facilitating panoramic investigation context-dependent crosstalk between development therapeutic agents.

Language: Английский

Citations

0