Wound Healing: A Cellular Perspective

Physiological Reviews, Journal Year: 2018, Volume and Issue: 99(1), P. 665 - 706

Published: Nov. 26, 2018

Wound healing is one of the most complex processes in human body. It involves spatial and temporal synchronization a variety cell types with distinct roles phases hemostasis, inflammation, growth, re-epithelialization, remodeling. With evolution single technologies, it has been possible to uncover phenotypic functional heterogeneity within several these types. There have also discoveries rare, stem subsets skin, which are unipotent uninjured state, but become multipotent following skin injury. Unraveling each their interactions other important understanding mechanisms normal wound closure. Changes microenvironment including alterations mechanical forces, oxygen levels, chemokines, extracellular matrix growth factor synthesis directly impact cellular recruitment activation, leading impaired states healing. Single technologies can be used decipher diseased such as chronic wounds hypertrophic scarring so that effective therapeutic solutions for developed.

Language: Английский

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Osteoblast-Osteoclast Communication and Bone Homeostasis

Cells, Journal Year: 2020, Volume and Issue: 9(9), P. 2073 - 2073

Published: Sept. 10, 2020

Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts osteoclasts communicate with each other to regulate cellular behavior, survival differentiation through direct cell-to-cell contact or secretory proteins. A interaction allows bidirectional transduction of activation signals EFNB2-EPHB4, FASL-FAS SEMA3A-NRP1, regulating Alternatively, produce range different molecules, including M-CSF, RANKL/OPG, WNT5A, WNT16, that promote suppress osteoclast development. Osteoclasts also influence osteoblast formation secretion soluble factors, S1P, SEMA4D, CTHRC1 C3. Here we review the current knowledge regarding membrane bound- factors governing

Language: Английский

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The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

Bioactive Materials, Journal Year: 2020, Volume and Issue: 6(7), P. 1973 - 1987

Published: Dec. 26, 2020

The tumor development and metastasis are closely related to the structure function of microenvironment (TME). Recently, TME modulation strategies have attracted much attention in cancer immunotherapy. Despite preliminary success immunotherapeutic agents, their therapeutic effects been restricted by limited retention time drugs TME. Compared with traditional delivery systems, nanoparticles unique physical properties elaborate design can efficiently penetrate specifically deliver major components In this review, we briefly introduce substitutes including dendritic cells, macrophages, fibroblasts, vasculature, tumor-draining lymph nodes hypoxic state, then review various targeting these applications therapy. addition, could be combined other therapies, chemotherapy, radiotherapy, photodynamic therapy, however, nanoplatform system may not effective all types tumors due heterogeneity different individuals. changes at stages during required further elucidated so that more individualized nanoplatforms designed.

Language: Английский

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The extracellular matrix as a multitasking player in disease

FEBS Journal, Journal Year: 2019, Volume and Issue: 286(15), P. 2830 - 2869

Published: March 25, 2019

Extracellular matrices (ECMs) are highly specialized and dynamic three-dimensional (3D) scaffolds into which cells reside in tissues. ECM is composed of a variety fibrillar components, such as collagens, fibronectin, elastin, non-fibrillar molecules proteoglycans, hyaluronan, glycoproteins including matricellular proteins. These macromolecular components interconnected forming complex networks that actively communicate with through binding to cell surface receptors and/or matrix effectors. ECMs exert diverse roles, either providing tissues structural integrity mechanical properties essential for tissue functions or regulating phenotype maintain homeostasis. molecular composition structure vary among tissues, markedly modified during normal repair well the progression various diseases. Actually, abnormal remodeling occurring pathologic circumstances drives disease by cell-matrix interactions. The importance also highlighted mutations genes give rise genetic disorders clinical phenotypes. In this review, we present critical emerging issues related assembly multitasking roles diseases osteoarthritis, fibrosis, cancer, mechanisms underlying matrix-based discussed. Research focused on 3D will help discover matrix-related causative abnormalities novel diagnostic tools therapeutic targets.

Language: Английский

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Myofibroblasts

Experimental Eye Research, Journal Year: 2015, Volume and Issue: 142, P. 56 - 70

Published: July 18, 2015

Language: Английский

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TGF-β1 – A truly transforming growth factor in fibrosis and immunity

Seminars in Cell and Developmental Biology, Journal Year: 2019, Volume and Issue: 101, P. 123 - 139

Published: Dec. 24, 2019

Language: Английский

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Keloids: The paradigm of skin fibrosis — Pathomechanisms and treatment

Matrix Biology, Journal Year: 2016, Volume and Issue: 51, P. 37 - 46

Published: Feb. 2, 2016

Language: Английский

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The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication

Matrix Biology, Journal Year: 2018, Volume and Issue: 68-69, P. 81 - 93

Published: Feb. 1, 2018

Language: Английский

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Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(39), P. 19609 - 19618

Published: Sept. 4, 2019

Pancreatic ductal adenocarcinoma (PDAC) has prominent extracellular matrix (ECM) that compromises treatments yet cannot be nonselectively disrupted without adverse consequences. ECM of PDAC, despite the recognition its importance, not been comprehensively studied in patients. In this study, we used quantitative mass spectrometry (MS)-based proteomics to characterize proteins normal pancreas and pancreatic intraepithelial neoplasia (PanIN)- PDAC-bearing from both human patients mouse genetic models, as well chronic pancreatitis patient samples. We describe detailed changes abundance complexity matrisome course PDAC progression. reveal an early up-regulated group PanIN, which are further uncover notable similarities between PDAC. assigned cellular origins by performing MS on multiple lines human-to-mouse xenograft tumors. found that, although stromal cells produce over 90% mass, elevated levels derived tumor cells, but those produced exclusively tend correlate with poor survival. Furthermore, distinct pathways were implicated regulating expression cancer cells. suggest rather than global suppression production, more precise manipulations, such targeting tumor-promoting their regulators could effective therapeutically.

Language: Английский

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Hepatic inflammatory responses in liver fibrosis

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 20(10), P. 633 - 646

Published: July 3, 2023

Language: Английский

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