Bioactive Materials,
Journal Year:
2021,
Volume and Issue:
12, P. 246 - 256
Published: Oct. 25, 2021
Pathogenic
bacteria
pose
a
devastating
threat
to
public
health.
However,
because
of
the
growing
bacterial
antibiotic
resistance,
there
is
an
urgent
need
develop
alternative
antibacterial
strategies
established
antibiotics.
Herein,
iron-doped
carbon
dots
(Fe-CDs,
∼3
nm)
nanozymes
with
excellent
photothermal
conversion
and
photoenhanced
enzyme-like
properties
are
developed
through
facile
one-pot
pyrolysis
approach
for
synergistic
efficient
therapy
wound
healing.
In
particular,
Fe
doping
endows
CDs
peroxidase
(POD)-like
activity,
which
lead
generation
heat
reactive
oxygen
species
(ROS)
Gram-positive
Gram-negative
killing.
This
study
demonstrates
Fe-CDs
have
significant
healing
efficiency
by
preventing
infection,
promoting
fibroblast
proliferation,
angiogenesis,
collagen
deposition.
Furthermore,
ultrasmall
size
possesses
good
biocompatibility
favoring
clinical
translation.
We
believe
that
nanozyme-mediated
therapeutic
platform
presented
here
expected
show
promising
applications
in
antibacterial.
Bioengineering,
Journal Year:
2021,
Volume and Issue:
8(5), P. 63 - 63
Published: May 11, 2021
Normal
wound
healing
progresses
through
inflammatory,
proliferative
and
remodeling
phases
in
response
to
tissue
injury.
Collagen,
a
key
component
of
the
extracellular
matrix,
plays
critical
roles
regulation
either
its
native,
fibrillar
conformation
or
as
soluble
components
milieu.
Impairments
any
these
stall
chronic,
non-healing
state
that
typically
requires
some
form
intervention
guide
process
back
completion.
Key
factors
hostile
environment
chronic
are
persistent
inflammation,
increased
destruction
ECM
caused
by
elevated
metalloproteinases
other
enzymes
improper
activation
mediators
process.
being
central
several
processes,
has
been
utilized
an
adjunct
therapy
promote
healing.
In
this
work
significance
collagen
different
biological
processes
relevant
reviewed
summary
current
literature
on
use
collagen-based
products
care
is
provided.
Biomolecules,
Journal Year:
2021,
Volume and Issue:
11(5), P. 700 - 700
Published: May 8, 2021
Skin
wounds
greatly
affect
the
global
healthcare
system,
creating
a
substantial
burden
on
economy
and
society.
Moreover,
situation
is
exacerbated
by
low
healing
rates,
which
in
fact
are
overestimated
reports.
Cutaneous
generally
classified
into
acute
chronic.
The
immune
response
plays
an
important
role
during
wound
healing.
activation
of
cells
factors
initiate
inflammatory
process,
facilitate
cleansing
promote
subsequent
tissue
However,
dysregulation
system
process
leads
to
persistent
inflammation
delayed
healing,
ultimately
result
chronic
wounds.
microenvironment
characterized
high
quantities
pro-inflammatory
macrophages,
overexpression
mediators
such
as
TNF-α
IL-1β,
increased
activity
matrix
metalloproteinases
abundance
reactive
oxygen
species.
frequently
complicated
bacterial
biofilms,
perpetuate
phase.
Continuous
microbial
biofilms
make
it
very
difficult
for
heal.
In
this
review,
we
discuss
innate
adaptive
immunity
pathogenesis
Furthermore,
review
latest
immunomodulatory
therapeutic
strategies,
including
modifying
macrophage
phenotype,
regulating
miRNA
expression
targeting
pro-
anti-inflammatory
improve
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(8), P. 1811 - 1811
Published: April 12, 2019
The
skin
is
a
complex
organ
that
has
devised
numerous
strategies,
such
as
physical,
chemical,
and
microbiological
barriers,
to
protect
the
host
from
external
insults.
In
addition,
contains
an
intricate
network
of
immune
cells
resident
tissue,
crucial
for
defense
well
tissue
homeostasis.
event
insult,
skin-resident
are
not
only
prevention
infection
but
also
reconstruction.
Deregulation
responses
often
leads
impaired
healing
poor
restoration
function.
this
review,
we
will
discuss
defensive
components
focus
on
function
in
homeostasis
their
role
wound
healing.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(6), P. 5604 - 5640
Published: Jan. 13, 2022
Tissue
engineering
is
a
promising
and
revolutionary
strategy
to
treat
patients
who
suffer
the
loss
or
failure
of
an
organ
tissue,
with
aim
restore
dysfunctional
tissues
enhance
life
expectancy.
Supramolecular
adhesive
hydrogels
are
emerging
as
appealing
materials
for
tissue
applications
owing
their
favorable
attributes
such
tailorable
structure,
inherent
flexibility,
excellent
biocompatibility,
near-physiological
environment,
dynamic
mechanical
strength,
particularly
attractive
self-adhesiveness.
In
this
review,
key
design
principles
various
supramolecular
strategies
construct
comprehensively
summarized.
Thereafter,
recent
research
progress
regarding
applications,
including
primarily
dermal
repair,
muscle
bone
neural
vascular
oral
corneal
cardiac
fetal
membrane
hepatic
gastric
systematically
highlighted.
Finally,
scientific
challenges
remaining
opportunities
underlined
show
full
picture
hydrogels.
This
review
expected
offer
comparative
views
critical
insights
inspire
more
advanced
studies
on
pave
way
different
fields
even
beyond
applications.
Cells,
Journal Year:
2021,
Volume and Issue:
10(8), P. 1959 - 1959
Published: Aug. 1, 2021
Exosomes
are
a
type
of
extracellular
vesicles,
produced
within
multivesicular
bodies,
that
then
released
into
the
space
through
merging
body
with
plasma
membrane.
These
vesicles
secreted
by
almost
all
cell
types
to
aid
in
vast
array
cellular
functions,
including
intercellular
communication,
differentiation
and
proliferation,
angiogenesis,
stress
response,
immune
signaling.
This
ability
contribute
several
distinct
processes
is
due
complexity
exosomes,
as
they
carry
multitude
signaling
moieties,
proteins,
lipids,
surface
receptors,
enzymes,
cytokines,
transcription
factors,
nucleic
acids.
The
favorable
biological
properties
exosomes
biocompatibility,
stability,
low
toxicity,
proficient
exchange
molecular
cargos
make
prime
candidates
for
tissue
engineering
regenerative
medicine.
Exploring
functions
payloads
can
facilitate
regeneration
therapies
provide
mechanistic
insight
paracrine
modulation
activities.
In
this
review,
we
summarize
current
knowledge
exosome
biogenesis,
composition,
isolation
methods.
We
also
discuss
emerging
healing
exosomal
cargos,
such
microRNAs,
brain
injuries,
cardiovascular
disease,
COVID-19
amongst
others.
Overall,
review
highlights
burgeoning
roles
potential
applications
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Nov. 8, 2022
Abstract
As
an
evolutionarily
conserved
signalling
network,
the
Hippo
pathway
plays
a
crucial
role
in
regulation
of
numerous
biological
processes.
Thus,
substantial
efforts
have
been
made
to
understand
upstream
signals
that
influence
activity
pathway,
as
well
its
physiological
functions,
such
cell
proliferation
and
differentiation,
organ
growth,
embryogenesis,
tissue
regeneration/wound
healing.
However,
dysregulation
can
cause
variety
diseases,
including
cancer,
eye
cardiac
pulmonary
renal
hepatic
immune
dysfunction.
Therefore,
therapeutic
strategies
target
dysregulated
components
might
be
promising
approaches
for
treatment
wide
spectrum
diseases.
Here,
we
review
key
critical
functions
controlled
by
pathway.
Additionally,
diseases
associated
with
alterations
potential
therapies
targeting
will
discussed.
