Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

Molecular Aspects of Medicine, Journal Year: 2018, Volume and Issue: 65, P. 2 - 15

Published: June 30, 2018

Language: Английский

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The extracellular matrix as a multitasking player in disease

FEBS Journal, Journal Year: 2019, Volume and Issue: 286(15), P. 2830 - 2869

Published: March 25, 2019

Extracellular matrices (ECMs) are highly specialized and dynamic three-dimensional (3D) scaffolds into which cells reside in tissues. ECM is composed of a variety fibrillar components, such as collagens, fibronectin, elastin, non-fibrillar molecules proteoglycans, hyaluronan, glycoproteins including matricellular proteins. These macromolecular components interconnected forming complex networks that actively communicate with through binding to cell surface receptors and/or matrix effectors. ECMs exert diverse roles, either providing tissues structural integrity mechanical properties essential for tissue functions or regulating phenotype maintain homeostasis. molecular composition structure vary among tissues, markedly modified during normal repair well the progression various diseases. Actually, abnormal remodeling occurring pathologic circumstances drives disease by cell-matrix interactions. The importance also highlighted mutations genes give rise genetic disorders clinical phenotypes. In this review, we present critical emerging issues related assembly multitasking roles diseases osteoarthritis, fibrosis, cancer, mechanisms underlying matrix-based discussed. Research focused on 3D will help discover matrix-related causative abnormalities novel diagnostic tools therapeutic targets.

Language: Английский

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Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: June 17, 2021

Abstract Fibrotic skin disease represents a major global healthcare burden, characterized by fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts are found to be heterogeneous in multiple fibrotic diseases, but heterogeneity diseases is not well characterized. In this study, we explore keloid, paradigm using single-cell RNA-seq. Our results indicate that keloid fibroblasts can divided into 4 subpopulations: secretory-papillary, secretory-reticular, mesenchymal pro-inflammatory. Interestingly, the percentage subpopulation significantly increased compared normal scar. Functional studies crucial for collagen overexpression keloid. Increased also another disease, scleroderma, suggesting broad mechanism fibrosis. These findings will help us better understand pathogenesis, provide potential targets therapies.

Language: Английский

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The Roles of Inflammation in Keloid and Hypertrophic Scars

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: Dec. 4, 2020

The underlying mechanisms of wound healing are complex but inflammation is one the determining factors. Besides its traditional role in combating against infection upon injury, characteristics and magnitude have dramatic impacts on pathogenesis scar. Keloids hypertrophic scars pathological that result from aberrant healing. They characterized by continuous local excessive collagen deposition. In this review, we aim at discussing how dysregulated contributes to scar formation. Immune cells, soluble inflammatory mediators, related intracellular signal transduction pathways our three subtopics encompassing events occurring associated with end, enumerate current potential medicines therapeutics for suppressing limiting progression Understanding initiation, progression, resolution will provide insights into formation useful developing effective treatments.

Language: Английский

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Toward understanding scarless skin wound healing and pathological scarring

F1000Research, Journal Year: 2019, Volume and Issue: 8, P. 787 - 787

Published: June 5, 2019

The efficient healing of skin wounds is crucial for securing the vital barrier function skin, but pathological wound and scar formation are major medical problems causing both physiological psychological challenges patients. A number tightly coordinated regenerative responses, including haemostasis, migration various cell types into wound, inflammation, angiogenesis, extracellular matrix, involved in process. In this article, we summarise central mechanisms processes excessive scarring acute healing, which can lead to keloids or hypertrophic scars, two fibrotic scars caused by burns other traumas resulting significant functional aesthetic disadvantages. addition, discuss recent developments related functions activated fibroblasts, matrix mechanical forces environment as well scarless healing. Understanding different pivotal developing new therapies prevent large wounds.

Language: Английский

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Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies

Life, Journal Year: 2021, Volume and Issue: 11(7), P. 665 - 665

Published: July 7, 2021

The skin is the biggest organ of human body which acts as a protective barrier against deleterious agents. When this damaged, organism promotes healing process with several molecular and cellular mechanisms, in order to restore physiological structure skin. control wound depends on correct balance among its different mechanisms. Any disruption these mechanisms can lead problems delay healing. impairment linked underlying factors well aging, nutrition, hypoxia, stress, infections, drugs, genetics, chronic diseases. Over years, numerous studies have been conducted discover approach best therapies for healing, including surgical procedures non-surgical treatments such topical formulations, dressings, or substitutes. Thus, general necessary facilitate direction further studies. This work provides updated concepts that interfere, used

Language: Английский

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Microneedle-mediated transdermal drug delivery for treating diverse skin diseases

Acta Biomaterialia, Journal Year: 2020, Volume and Issue: 121, P. 119 - 133

Published: Dec. 5, 2020

Language: Английский

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Keloids: a review of therapeutic management

International Journal of Dermatology, Journal Year: 2020, Volume and Issue: 60(6), P. 661 - 671

Published: Sept. 9, 2020

Abstract Keloid scar formation arises from a disorganized fibroproliferative collagen response that extends beyond the original wound margins because of excessive production extracellular matrix (ECM). Despite treatment options for keloid scars including medical and surgical therapies, such as intralesional steroid injection excision, recurrence rate remains high. Herein we consolidate recently published narrative reviews, systematic meta‐analyses to provide an overview updated recommendations keloidal formation. PubMed search engine was used access MEDLINE database investigate updates regarding incidence treatment. More than 100 articles were reviewed. management multimodal approach. There continues be no gold standard provides consistently low rate; however, increasing number available treatments synergistic combinations these (i.e., laser‐based devices in combination with steroids, or 5‐fluorouracil (5‐FU) therapy) is showing favorable results. Future studies could target efficacy novel modalities autologous fat grafting stem cell‐based therapies) management. This review article guidelines keloids discusses insight into assist patient‐focused, evidence‐based clinical decision making.

Language: Английский

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Scars

Nature Reviews Disease Primers, Journal Year: 2023, Volume and Issue: 9(1)

Published: Nov. 16, 2023

Language: Английский

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Cellular and Molecular Processes in Wound Healing

Biomedicines, Journal Year: 2023, Volume and Issue: 11(9), P. 2526 - 2526

Published: Sept. 13, 2023

This review summarizes the recent knowledge of cellular and molecular processes that occur during wound healing. However, these biological mechanisms have yet to be defined in detail; this is demonstrated by fact alterations events pathological states, such as keloids, consisting excessive formation scars, consequences detail. Attention also dedicated new therapies proposed for kinds pathologies. Awareness scientific problems important experts various disciplines who are confronted with presentations daily.

Language: Английский

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