Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10296 - 10296

Published: June 18, 2023

Hyaluronic acid (HA) is a glycosaminoglycan widely distributed in the human body, especially body fluids and extracellular matrix of tissues. It plays crucial role not only maintaining tissue hydration but also cellular processes such as proliferation, differentiation, inflammatory response. HA has demonstrated its efficacy powerful bioactive molecule for skin antiaging atherosclerosis, cancer, other pathological conditions. Due to biocompatibility, biodegradability, non-toxicity, non-immunogenicity, several HA-based biomedical products have been developed. There an increasing focus on optimizing production achieve high-quality, efficient, cost-effective products. This review discusses HA’s structure, properties, through microbial fermentation. Furthermore, it highlights applications emerging sectors biomedicine.

Language: Английский

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Microneedles as a momentous platform for psoriasis therapy and diagnosis: A state-of-the-art review

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 632, P. 122591 - 122591

Published: Jan. 7, 2023

Language: Английский

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Liposome-loaded polymeric microneedles for enhanced skin deposition of rifampicin

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 646, P. 123446 - 123446

Published: Sept. 24, 2023

Methicillin-resistant Staphylococcus aureus (MRSA) is a prevailing bacterial pathogen linked to superficial skin and soft tissue infections (SSTIs). Rifampicin (RIF), potent antibiotic against systemic localised staphylococcal infections, faces limitations due its low solubility. This constraint hampers therapeutic potential for MRSA-induced SSTIs. To address this, an advanced liposomal system was designed efficient dermal RIF delivery. Rifampicin-loaded liposomes (LipoRIF) were embedded within polymeric dissolving microneedles (DMNs) enable targeted intradermal drug A robust Design of Experiment (DoE) methodology guided the systematic preparation optimisation LipoRIF formulations. The optimal formulation integrated DMNs. These LipoRIF-DMNs exhibited favourable mechanical properties effective insertion characteristics. Notably, in vitro assays on deposition unveiled transformative result - DMN platform significantly enhanced skin, surpassing dispersion alone. Moreover, displayed minimal cytotoxicity toward cells. Encouragingly, rigorous antimicrobial evaluations demonstrated LipoRIF-DMNs' capacity inhibit MRSA growth compared control group. propose potentially enhanced, minimally invasive approach effectively manage SSTIs ailments stemming from infections.

Language: Английский

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Recent Approaches for the Topical Treatment of Psoriasis Using Nanoparticles

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 449 - 449

Published: March 25, 2024

Psoriasis (PSO) is a chronic autoimmune skin condition characterized by the rapid and excessive growth of cells, which leads to formation thick, red, scaly patches on surface skin. These can be itchy painful, they may cause discomfort for patients affected this condition. Therapies psoriasis aim alleviate symptoms, reduce inflammation, slow down cell growth. Conventional topical treatment options are non-specific, have low efficacy associated with adverse effects, why researchers investigating different delivery mechanisms. A novel approach drug using nanoparticles (NPs) shows promise in reducing toxicity improving therapeutic efficacy. The unique properties NPs, such as their small size large area, make them attractive targeted delivery, enhanced stability, controlled release. In context PSO, NPs designed deliver active ingredients anti-inflammatory effect, immunosuppressants, or other compounds directly areas. formulations offer improved access epidermis facilitate better absorption, thus enhancing conventional anti-psoriatic drugs. increase surface-to-volume ratio, resulting penetration through skin, including intracellular, intercellular, trans-appendage routes. present review aims discuss latest approaches therapy PSO NPs. It intended summarize results vitro vivo examinations carried out last few years regarding effectiveness safety nanoparticles.

Language: Английский

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The Advancement and Obstacles in Improving the Stability of Nanocarriers for Precision Drug Delivery in the Field of Nanomedicine

Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(8), P. 686 - 721

Published: Feb. 27, 2024

Nanocarriers have emerged as a promising class of nanoscale materials in the fields drug delivery and biomedical applications. Their unique properties, such high surface area- tovolume ratios enhanced permeability retention effects, enable targeted therapeutic agents to specific tissues or cells. However, inherent instability nanocarriers poses significant challenges their successful application. This review highlights importance nanocarrier stability applications its impact on biocompatibility, delivery, long shelf life, performance, efficacy, reduced side prolonged circulation time, delivery. Enhancing requires careful design, engineering, optimization physical chemical parameters. Various strategies cutting-edge techniques employed improve are explored, with focus By understanding advances stability, this aims contribute development implementation nanocarrier- based therapies clinical settings, advancing field nanomedicine.

Language: Английский

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Preparation and Properties of Polyvinylpyrrolidone/Sodium Carboxymethyl Cellulose Soluble Microneedles

Materials, Journal Year: 2023, Volume and Issue: 16(9), P. 3417 - 3417

Published: April 27, 2023

Transdermal drug delivery is a new means of delivering drugs through the skin to achieve therapeutic effects. Microneedles have several advantages, including low cost, easy self-administration, and high efficiency. Different polymers affect morphology, mechanical properties, efficiency microneedles. To study performance limitations microneedles (MNs), we prepared different ratios polymers. MNs were fabricated from polyvinylpyrrolidone (PVP) sodium carboxymethyl cellulose (CMC-Na) using centrifugal molding method. Needle formability, other properties evaluated compare performances with ratios. PVP CMC-Na intermixed at water as solvent. The soluble by mold casting. thermodynamic crystallinity studied scanning electron microscopy (SEM), thermogravimetric analysis (TG), differential calorimetric (DSC), X-ray diffraction (XRD). results showed that composite good thermal stability. Among compositions tested, 10% PVP/2% microneedle demonstrated best regular surface morphology relatively decomposition melting temperatures. These indicate appropriate two materials possess formability properties.

Language: Английский

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Breakthroughs and bottlenecks of psoriasis therapy: Emerging trends and advances in lipid based nano-drug delivery platforms for dermal and transdermal drug delivery

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 84, P. 104548 - 104548

Published: May 12, 2023

Language: Английский

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Microneedles Based on a Biodegradable Polymer—Hyaluronic Acid

Polymers, Journal Year: 2024, Volume and Issue: 16(10), P. 1396 - 1396

Published: May 14, 2024

Transdermal transport can be challenging due to the difficulty in diffusing active substances through outermost layer of epidermis, as primary function skin is protect against entry exogenous compounds into body. In addition, penetration epidermis for hydrophilic nature and particles larger than 500 Da highly limited physiological properties non-polar its layer, namely stratum corneum. A solution this problem use microneedles, which “bypass” problematic epidermal by dispensing substance directly deeper layers skin. Microneedles obtained with various materials come different types. Of special interest are carriers based on biodegradable biocompatible polymers, such polysaccharides. Therefore, paper reviews latest literature methods obtain hyaluronic acid-based microneedles. It focuses current advancements field consequently provides an opportunity guide future research area.

Language: Английский

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A novel natural polysaccharide dissolving microneedle capable of adsorbing pus to load EGCG for the treatment of acne vulgaris

Materials & Design, Journal Year: 2024, Volume and Issue: 238, P. 112639 - 112639

Published: Jan. 8, 2024

Acne vulgaris is a common inflammatory skin disease associated with Propionibacterium acnes (P. acnes), serious physical and psychological effects on patients. Conventional topical use of antibiotics not effective due to the barrier oral administration can adversely affect intestinal flora. Microneedle novel type localized drug delivery system that noninvasively breaks through stratum corneum effectively enhances transdermal absorption drugs. Here, Bletilla striata polysaccharide (BSP)/Hyaluronic acid (HA) loaded Epigallocatechin gallate (EGCG) was used as microneedle body easily penetrate epidermis enhance antibacterial ability. Polyvinyl alcohol (PVA) Diatomaceous earth (DE) are backing absorb pus bacterial debris, prevent re-infection bacteria promote healing. Compared traditional antibiotics, excellent permeability EGCG @ BSP/ HA MNs studied here improve efficacy solve side resistance. In vivo studies in mice models induced by P. showed this could reduce swelling, inhibit growth levels TNF-α, IL-8 MMP-2. summary, study provides an ideal antimicrobial for treatment acne vulgaris.

Language: Английский

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Development of pH-Sensitive Nanoparticle Incorporated into Dissolving Microarray Patch for Selective Delivery of Methotrexate

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(4)

Published: March 27, 2024

Language: Английский

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