Injectable chitosan/xyloglucan composite hydrogel with mechanical adaptivity and endogenous bioactivity for skin repair

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 313, P. 120904 - 120904

Published: April 13, 2023

Language: Английский

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Marine collagen-chitosan-fucoidan/chondroitin sulfate cryo-biomaterials loaded with primary human cells envisaging cartilage tissue engineering

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 241, P. 124510 - 124510

Published: April 19, 2023

Cartilage repair after a trauma or degenerative disease like osteoarthritis (OA) continues to be big challenge in current medicine due the limited self-regenerative capacity of articular cartilage tissues. To overcome limitations, tissue engineering and regenerative (TERM) adjacent areas have focused their efforts on new therapeutical procedures materials capable restoring normal functionalities through polymeric scaffolding stem cell approaches. For this, sustainable exploration marine origin has emerged last years as natural alternative mammal sources, benefiting from biological properties (e.g., biocompatibility, biodegradability, no toxicity, among others) for development several types scaffolds. In this study, collagen(jCOL)-chitosan(sCHT)-fucoidan(aFUC)/chondroitin sulfate(aCS) were cryo-processed (-20 °C, -80 -196 °C) chemical-free crosslinking approach was explored establish cohesive stable cryogel materials. The cryogels intensively characterized assess oscillatory behavior, thermal structural stability, thixotropic (around 45 % best formulations), injectability, surface organization. Additionally, demonstrate an interesting microenvironment vitro studies using human adipose-derived cells (hASCs), supporting viability proliferation. both physic-chemical studies, systems that contain fucoidan formulations, i.e., C

Language: Английский

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An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications

Polymers, Journal Year: 2023, Volume and Issue: 15(4), P. 1020 - 1020

Published: Feb. 17, 2023

Soft tissues diseases significantly affect patients quality of life and usually require targeted, costly sometimes constant interventions. With the average lifetime increase, a proportional increase age-related soft has been witnessed. Due to this, last two decades have seen tremendous demand for minimally invasive one-step resolutive procedures. Intensive scientific industrial research led recognition injectable formulations as new advantageous approach in management complex that are challenging treat with conventional strategies. Among them, collagen-based products revealed be one most promising among bioactive biomaterials-based formulations. Collagen is abundant structural protein vertebrate connective and, because its non-structural role, widely used multifunctional biomaterials health-related sectors, including medical care cosmetics. Indeed, historically considered “gold standard” from 1981 paving way development generation fillers. A huge number approved worldwide clinical use routinely introduced many settings both aesthetic regenerative surgery. In this context, review article aims an update on outcomes injectables medicine 20 years in-depth focus their safety effectiveness treatment integumental, gastrointestinal, musculoskeletal, urogenital apparatus.

Language: Английский

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Calcium phosphate bone cements as local drug delivery systems for bone cancer treatment

Biomaterials Advances, Journal Year: 2023, Volume and Issue: 148, P. 213367 - 213367

Published: March 3, 2023

Bone cancer is usually a metastatic disease, affecting people of all ages. Its effective therapy requires targeted drug administration locally at the site so that surrounding healthy organs and tissues stay unharmed. Upon thorough literature search, tremendous number published articles are reporting on development calcium phosphate cements (CPCs) for treatment variety diseases, such as osteoporosis, osteoarthritis, osteomyelitis, other musculoskeletal disorders. However, just limited research employs CPCs specifically bone treatment. In this review article, we study factors influencing local release from particularly focus therapy. Finally, locate deficiencies in regarding specific topic propose which perspectives should be considered discussed future articles.

Language: Английский

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Alginate-based hydrogels mediated biomedical applications: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135019 - 135019

Published: Aug. 28, 2024

Language: Английский

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