Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(6), P. 1856 - 1856
Published: March 10, 2025
The
extracellular
matrix
(ECM)
is
the
common
denominator
of
more
than
50
chronic
diseases.
Some
these
pathologies
lead
to
enhanced
tissue
formation
and
deposition,
whereas
others
are
associated
with
increased
degradation,
some
exhibit
a
combination
both,
leading
severe
alterations.
To
develop
effective
therapies
for
diseases
affecting
lung,
liver,
kidney,
skin,
intestine,
musculoskeletal
system,
heart,
solid
tumors,
we
need
modulate
ECM’s
composition
restore
its
organization
function.
Across
diverse
organ
diseases,
there
denominators
distinguishing
factors
in
this
fibroinflammatory
axis,
which
may
be
used
foster
new
insights
into
drug
development
across
disease
indications.
2nd
Extracellular
Matrix
Pharmacology
Congress
took
place
Copenhagen,
Denmark,
from
17
19
June
2024
was
hosted
by
International
Society
Pharmacology.
event
attended
450
participants
35
countries,
among
whom
were
prominent
scientists
who
brought
together
state-of-the-art
research
on
asked
important
questions
facilitate
development.
We
highlight
key
aspects
ECM
lungs,
tumors
advance
our
understanding
central
targets
also
advances
tools
technology
that
enable
development,
thereby
supporting
ECM.
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
66, P. 329 - 347
Published: Jan. 11, 2024
Bone
metabolism
can
maintain
the
normal
homeostasis
and
function
of
bone
tissue.
Once
balance
is
broken,
it
will
cause
osteoporosis,
osteoarthritis,
defects,
tumors,
or
other
diseases.
However,
such
orthopedic
diseases
still
have
many
limitations
in
clinical
treatment,
as
drug
restrictions,
tolerance,
side
effects,
implant
rejection.
review:
In
complex
therapy
regeneration,
extracellular
derivatives
become
a
promising
research
focus
to
solve
problems
metabolic
These
derivatives,
which
include
components
matrix,
growth
factors,
vesicles,
significant
therapeutic
potential.
It
has
advantages
good
biocompatibility,
low
immune
response,
dynamic
demand
for
The
purpose
this
review
provide
comprehensive
perspective
on
elucidate
intrinsic
properties
versatility
derivatives.
Further
discussion
them
innovative
advanced
materials
improving
effectiveness
regeneration
processes.
Key
scientific
concepts
review,
we
first
listed
types
functions
three
Then,
discussed
effects
different
cell
sources
metabolism.
Subsequently,
collected
applications
treatment
summarized
challenges
applications.
Finally,
prospected
novel
We
hope
that
understanding
new
solutions
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 3, 2025
Matrix-assisted
laser
desorption
ionization
mass
spectrometry
imaging
(MALDI-MSI)
has
been
used
to
generate
spatial
maps
of
lipids,
metabolites,
peptides,
proteins,
and
glycans
in
tissues;
however,
its
use
for
mapping
extracellular
matrix
(ECM)
protein
distributions
is
underexplored.
ECM
proteins
play
a
major
role
various
pathological
conditions,
changes
their
affect
the
function
morphology
cells
within
tissues.
detection
challenging
because
they
are
large,
insoluble,
undergo
post-translational
modifications,
such
as
glycosylation.
We
describe
here
decellularization
tissue
sections
coupled
with
serial
enzymatic
digestions
PNGaseF
trypsin
improve
MALDI-MSI
without
disrupting
architecture.
Decellularization
leads
3-fold
increase
number
that
measured
by
MALDI-MSI.
also
introduce
binary
colocalization
method
identification,
which
increases
confidently
detected.
Together,
these
methods
enhance
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7435 - 7435
Published: April 18, 2023
The
extracellular
matrix
(ECM)
of
the
brain
is
a
dynamic
structure
made
up
vast
network
bioactive
macromolecules
that
modulate
cellular
events.
Structural,
organizational,
and
functional
changes
in
these
due
to
genetic
variation
or
environmental
stressors
are
thought
affect
functions
may
result
disease.
However,
most
mechanistic
studies
date
usually
focus
on
aspects
diseases
pay
less
attention
relevance
processes
governing
nature
disease
pathogenesis.
Thus,
ECM's
diversified
biological
roles,
increasing
interest
its
involvement
disease,
lack
sufficient
compiled
evidence
regarding
relationship
with
Parkinson's
(PD)
pathology,
we
aimed
compile
existing
boost
current
knowledge
area
provide
refined
guidance
for
future
research.
Here,
this
review,
gathered
postmortem
tissue
induced
pluripotent
stem
cell
(iPSC)-related
from
PubMed
Google
Scholar
identify,
summarize
describe
common
macromolecular
alterations
expression
ECM
components
(PD).
A
literature
search
was
conducted
until
10
February
2023.
overall
hits
database
manual
proteomic
transcriptome
were
1243
1041
articles,
respectively.
Following
full-text
articles
24
transcriptomic
found
be
eligible
inclusion.
According
studies,
proteins
such
as
collagens,
fibronectin,
annexins,
tenascins
recognized
differentially
expressed
Transcriptomic
displayed
dysregulated
pathways
including
ECM-receptor
interaction,
focal
adhesion,
adhesion
molecules
limited
number
relevant
accessed
our
search,
indicating
much
work
remains
carried
out
better
understand
roles
neurodegeneration
believe
review
will
elicit
focused
primary
thus
support
ongoing
efforts
discovery
development
diagnostic
biomarkers
well
therapeutic
agents
Journal of Cell Science,
Journal Year:
2023,
Volume and Issue:
136(17)
Published: Aug. 9, 2023
The
extracellular
matrix
(ECM)
is
a
complex
meshwork
of
proteins
that
forms
the
scaffold
all
tissues
in
multicellular
organisms.
It
plays
crucial
roles
aspects
life
-
from
orchestrating
cell
migration
during
development,
to
supporting
tissue
repair.
also
critical
etiology
or
progression
diseases.
To
study
this
compartment,
we
have
previously
defined
compendium
genes
encoding
ECM
and
ECM-associated
for
multiple
We
termed
'matrisome'
further
classified
matrisome
components
into
different
structural
functional
categories.
This
nomenclature
now
largely
adopted
by
research
community
annotate
'-omics'
datasets
has
contributed
advance
both
fundamental
translational
research.
Here,
report
development
Matrisome
AnalyzeR,
suite
tools
including
web-based
application
an
R
package.
web
can
be
used
anyone
interested
annotating,
classifying
tabulating
molecules
large
without
requiring
programming
knowledge.
companion
package
available
more
experienced
users,
processing
larger
additional
data
visualization
options.
AJP Cell Physiology,
Journal Year:
2023,
Volume and Issue:
325(1), P. C90 - C128
Published: May 8, 2023
The
extracellular
matrix
(ECM),
composed
of
interlinked
proteins
outside
cells,
is
an
important
component
the
human
body
that
helps
maintain
tissue
architecture
and
cellular
homeostasis.
As
people
age,
ECM
undergoes
changes
can
lead
to
age-related
morbidity
mortality.
Despite
its
importance,
aging
remains
understudied
in
field
geroscience.
In
this
review,
we
discuss
core
concepts
integrity,
outline
challenges
subsequent
pathologies
diseases,
summarize
diagnostic
methods
detecting
a
faulty
ECM,
provide
strategies
targeting
To
conceptualize
this,
built
technology
research
tree
hierarchically
visualize
possible
sequences
for
studying
aging.
This
strategic
framework
will
hopefully
facilitate
development
future
on
interventions
restore
which
could
potentially
new
drugs
or
therapeutic
promoting
health
during
