Comparative Analysis of the Prevalence of Dysphagia in Patients with Mild COVID-19 and Those with Aspiration Pneumonia Alone: Findings of the Videofluoroscopic Swallowing Study DOI Creative Commons
Junhyung Kim, Byung-Ju Ryu,

Yun Hee Kim

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(10), P. 1851 - 1851

Published: Oct. 18, 2023

Background and Objectives: Patients recovering from mild coronavirus disease (COVID-19) reportedly have dysphagia or difficulty in swallowing. We compared the prevalence of between patients diagnosed with COVID-19 those aspiration pneumonia alone. Materials Methods: A retrospective study was conducted January 2020 to June 2023 160 referred for a videofluoroscopic swallowing (VFSS) assess dysphagia. The cohort included 24 pneumonia, 30 without 106 reviewed demographic data, comorbidities, VFSS results using penetration-aspiration scale (PAS) functional (FDS). Results: In comparing (Group A) alone B), no significant differences were observed baseline characteristics, including dysphagia-related comorbidities groups. Group showed milder dysphagia, as evidenced by lower PAS FDS scores, shorter oral pharyngeal transit times (p = 0.001 p 0.003, respectively), fewer residues vallecula pyriform sinuses < 0.03, respectively). When subdivided into A1) A2), both subgroups outperformed B terms specific metrics, such time 0.01), 0.04 0.02, residue However, improved triggering reflex A2 0.02). Conclusion: Mild less severe than This finding consistent across parameters, even when group based on status pneumonia.

Language: Английский

Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options DOI
Yasaman Nazerian,

Mobina Ghasemi,

Younes Yassaghi

et al.

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 113, P. 109428 - 109428

Published: Nov. 7, 2022

Language: Английский

Citations

52
SARS-CoV-2 cell entry beyond the ACE2 receptor DOI Open Access
Shamila D. Alipoor, Mehdi Mirsaeidi

Molecular Biology Reports, Journal Year: 2022, Volume and Issue: 49(11), P. 10715 - 10727

Published: June 26, 2022

Language: Английский

Citations

49
Long-Term Effects of SARS-CoV-2 in the Brain: Clinical Consequences and Molecular Mechanisms DOI Open Access
Ann‐Charlotte Granholm

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(9), P. 3190 - 3190

Published: April 28, 2023

Numerous investigations have demonstrated significant and long-lasting neurological manifestations of COVID-19. It has been suggested that as many four out five patients who sustained COVID-19 will show one or several symptoms can last months after the infection run its course. Neurological are most common in people less than 60 years age, while encephalopathy is more those over 60. Biological mechanisms for these need to be investigated may include both direct indirect effects virus on brain spinal cord. Individuals with Alzheimer’s disease (AD) related dementia, well persons Down syndrome (DS), especially vulnerable COVID-19, but biological reasons this not clear. Investigating consequences an urgent emerging medical need, since close 700 million worldwide now had at least once. likely there a new burden healthcare economy dealing long-term severe SARS-CoV-2 infections long COVID, even younger generations. Interestingly, acute strikingly similar observed mild traumatic injury (mTBI) concussion, including dizziness, balance issues, anosmia, headaches. The possible convergence pathways involved discussed. current review focused commonly described symptoms, molecular involved.

Language: Английский

Citations

24
Potential for Early Noninvasive COVID-19 Detection Using Electronic-Nose Technologies and Disease-Specific VOC Metabolic Biomarkers DOI Creative Commons
A. D. Wilson,

Lisa Beth Forse

Sensors, Journal Year: 2023, Volume and Issue: 23(6), P. 2887 - 2887

Published: March 7, 2023

The established efficacy of electronic volatile organic compound (VOC) detection technologies as diagnostic tools for noninvasive early COVID-19 and related coronaviruses has been demonstrated from multiple studies using a variety experimental commercial devices capable detecting precise mixtures VOC emissions in human breath. activities numerous global research teams, developing novel electronic-nose (e-nose) methods, have generated empirical laboratory clinical trial test results based on the different types host VOC-biomarker metabolites specific chemical classes. COVID-19-specific biomarkers are derived disease-induced changes metabolic pathways by SARS-CoV-2 viral pathogenesis. unique mechanisms proposed recent researchers to explain how causes damage organ systems throughout body associated with symptom combinations, cytokine storms physiological cascades that disrupt normal biochemical processes through gene dysregulation generate disease-specific targeted e-nose detection. This paper reviewed methods applications VOC-detection early, diagnosis infections. In addition, metabolomic (quantitative) biomarkers, consisting host-derived VOCs identified exhaled breath patients, were summarized possible sources useful confirming supporting diagnoses.

Language: Английский

Citations

23
Transcriptome and machine learning analysis of the impact of COVID-19 on mitochondria and multiorgan damage DOI Creative Commons

Yu-Yu Chang,

An‐Chi Wei

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(1), P. e0297664 - e0297664

Published: Jan. 31, 2024

The effects of coronavirus disease 2019 (COVID-19) primarily concern the respiratory tract and lungs; however, studies have shown that all organs are susceptible to infection by severe acute syndrome 2 (SARS-CoV-2). COVID-19 may involve multiorgan damage from direct viral invasion through angiotensin-converting enzyme (ACE2), inflammatory cytokine storms, or other secondary pathways. This study involved analysis publicly accessible transcriptome data Gene Expression Omnibus (GEO) database for identifying significant differentially expressed genes related an investigation relating pathways associated with mitochondrial, cardiac, hepatic, renal toxicity in COVID-19. Significant were identified ranked statistical approaches, derived biological meaning feature importance; both utilized as machine learning features verification. Sample set selection was based on performance, sample size, imbalanced state, overfitting assessment. Machine served a verification tool facilitating testing hypotheses incorporating gene list adjustment. A subsequent in-depth pathway network conducted explore whether is impairments via mitochondrial infection. showed potential ACE2, pathways, suggesting medical interventions COVID-19-induced damage.

Language: Английский

Citations

4
SARS-CoV-2 Invasion and Pathological Links to Prion Disease DOI Creative Commons
Walter J. Lukiw,

Vivian Jaber,

Aileen I. Pogue

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(9), P. 1253 - 1253

Published: Sept. 7, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19 disease, is a highly infectious and transmissible viral pathogen that continues to impact human health globally. Nearly ~600 million people have been infected with SARS-CoV-2, about half exhibit some degree continuing complication, generically referred as long COVID. Lingering often serious neurological problems for patients in post-COVID-19 recovery period include brain fog, behavioral changes, confusion, delirium, deficits intellect, cognition memory issues, loss balance coordination, vision, visual processing hallucinations, encephalopathy, encephalitis, neurovascular or cerebrovascular insufficiency, and/or impaired consciousness. Depending upon patient’s age at onset other factors, up ~35% all elderly develop mild-to-severe encephalopathy due complications arising from SARS-CoV-2-induced cytokine storm surge cytokine-mediated pro-inflammatory immune signaling. In fact, this syndrome: (i) appears predispose aged development complications, especially those who experienced more grade infection; (ii) lies along interactive pathological pathways involving SARS-CoV-2 infection promotes parallel intensification progressive lethal conditions, (iii) strongly associated symptomology, onset, prion disease (PrD) insidious incurable syndromes. This commentary paper will evaluate recent peer-reviewed studies intriguing area SARS-CoV-2-associated neuropathology assess how chronic, viral-mediated changes CNS contribute cognitive decline PrD progressive, age-related neurodegenerative disorders.

Language: Английский

Citations

17
Oral intake of Kluyveromyces marxianus B0399 plus Lactobacillus rhamnosus CECT 30579 to mitigate symptoms in COVID-19 patients: A randomized open label clinical trial DOI
Vicente Navarro‐López,

Adriana Hernández-Belmonte,

Maria Isabel Pérez Soto

et al.

Medicine in Microecology, Journal Year: 2022, Volume and Issue: 14, P. 100061 - 100061

Published: Aug. 24, 2022

Language: Английский

Citations

15
SARS-CoV-2, long COVID, prion disease and neurodegeneration DOI Creative Commons

Yuhai Zhao,

Vivian Jaber,

Walter J. Lukiw

et al.

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Sept. 27, 2022

OPINION article Front. Neurosci., 27 September 2022Sec. Neurodegeneration Volume 16 - 2022 | https://doi.org/10.3389/fnins.2022.1002770

Citations

13
Suffocation in asthma and COVID-19: Supplementation of inhaled corticosteroids with alkaline hydrogen peroxide as an alternative to ECMO DOI Open Access
Aleksandr Urakov, Natalya Urakova, Петр Д. Шабанов

et al.

Published: July 11, 2023

Suffocation syndrome is the leading cause of hypoxia and mortality in most common lung diseases, asthma COVID-19. Inhaled corticosteroids (ICSs) have been shown to be main-stay critical care these diseases. Meanwhile, from strangulated highest low-income countries because ICSs are not currently available many patients. Warm alkaline hydrogen peroxide solutions (WAHPSs) reportedly invented recent years urgently turn thick sputum, mucus, pus, serous fluid, blood clots other biological masses con-taining enzyme catalase into a fluffy oxygenated foam. It has that mechanism action WAHPSs consists saponification lipid protein-lipid complexes bi-ological their transformation oxygen foam, decomposed water gas under At excess absorbed through lungs increases saturation. Based on described high availability ingre-dients, it suggested choking COVID-19 can reduced by combining with inhaled WAHPSs, especially poor countries. The essence inventions underlying formation given.

Language: Английский

Citations

7
Post-COVID-19 syndrome management: Utilizing the potential of dietary polysaccharides DOI Open Access
Kit‐Leong Cheong, Biao Yu, Bo Teng

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 166, P. 115320 - 115320

Published: Aug. 17, 2023

The COVID-19 pandemic has caused significant global impact, resulting in long-term health effects for many individuals. As more patients recover, there is a growing need to identify effective management strategies ongoing concerns, such as post-COVID-19 syndrome, characterized by persistent symptoms or complications beyond several weeks months from the onset of symptoms. In this review, we explore potential dietary polysaccharides promising approach managing syndrome. We summarize immunomodulatory, antioxidant, antiviral, and prebiotic activities Furthermore, review investigates role enhancing immune response, regulating function, improving oxidative stress, inhibiting virus binding ACE2, balancing gut microbiota, increasing functional metabolites. These properties may help alleviate symptoms, providing avenue treatment strategies.

Language: Английский

Citations

7