Genome plasticity in Candida albicans: A cutting-edge strategy for evolution, adaptation, and survival DOI Creative Commons
Ifeanyi Elibe, Emeka Innocent Nweze, Emmanuel A. Eze

et al.

Infection Genetics and Evolution, Journal Year: 2022, Volume and Issue: 99, P. 105256 - 105256

Published: Feb. 26, 2022

Candida albicans is the most implicated fungal species that grows as a commensal or opportunistic pathogen in human host. It associated with many life-threatening infections, especially immunocompromised persons. The genome of very flexible and can withstand wide assortment variations continuously changing environment. Thus, plasticity central to its adaptation has long been considerable interest. C. diploid heterozygous highly dynamic display variation from small large scale chromosomal rearrangement aneuploidy, which have implications drug resistance, virulence, pathogenicity. This review presents an up-to-date overview recent genomic studies involving albicans. discusses accumulating evidence shows how mitotic recombination events, ploidy dynamics, loss heterozygosity (LOH) influence evolution, adaptation, survival Understanding factors affect crucial for proper understanding rapid development adjustment therapeutic strategies mitigate their spread.

Language: Английский

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis DOI Creative Commons

Tatiana Y. Hargrove,

Laura Friggeri,

Z. Wawrzak

et al.

Journal of Biological Chemistry, Journal Year: 2017, Volume and Issue: 292(16), P. 6728 - 6743

Published: March 4, 2017

Language: Английский

Citations

320
Two New Triterpenoid Saponins with Antifungal Activity from Camellia sinensis Flowers DOI Open Access
Jian-Fa Zong, Zhibo Hong, Zhan Hu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1147 - 1147

Published: Jan. 28, 2025

Two new triterpenoid saponins, namely camsinsaponins A and B (1, 2), along with two known congeners (3, 4) were isolated from Camellia sinensis flowers. Their structures determined by extensive spectroscopic data. All compounds assessed for antifungal bioactivity against Candida albicans, glabrata, tropicalis. Compounds 1–4 showed excellent inhibitory effects. Notably, in regard to 1 2, their MIC values C. albicans close those of the positive control, fluconazole. Furthermore, elements on glabrata better than The aforementioned findings offer valuable insights future development novel therapeutic strategies drug-resistant infections.

Language: Английский

Citations

3
Antimicrobial Compounds Produced by Vaginal Lactobacillus crispatus Are Able to Strongly Inhibit Candida albicans Growth, Hyphal Formation and Regulate Virulence-related Gene Expressions DOI Creative Commons
Shuai Wang,

Qiangyi Wang,

Ence Yang

et al.

Frontiers in Microbiology, Journal Year: 2017, Volume and Issue: 08

Published: April 4, 2017

The female vaginal environment contains diverse microorganisms, and their interactions play significant roles in health disease. Lactobacillus species are the predominant microorganisms healthy women relevant as a barrier to defense against pathogens, including Candida albicans. yeast-to-hyphae transition is believed be determinant of C. albicans pathogenesis. In this study, we investigated effects isolates L. crispatus (seven strains), gasseri (six jensenii (five strains) on growth, hyphal formation virulence-related genes expression ATCC 10231. We found that showed most antimicrobial activities microplate-based liquid medium assay (P < 0.05). All seven cell-free supernatants (CFS) from strains reduced growth by >60%. might due productions some secretory compounds addition H2O2 organic acids. Furthermore, each CFS was significantly suppress under hyphae-inducing conditions (RPMI 1640 supplemented with 10% fetal bovine serum). hyphae inhibition rates treated crispatus, gasseri, were 88.3 ± 3.02%, 84.9 6.0%, 81.9 6.2%, respectively. Moreover, hyphae-specific (ALS3, HWP1, ECE1, EAP1, SAP5) transcriptional regulatory (EFG1, TEC1, NRG1) analyzed using quantitative real-time PCR. results demonstrated down-regulated ALS3 (0.140-fold)), HWP1 (0.075-fold), ECE1 (0.045-fold), while up-regulated negative regulator gene NRG1 1.911-fold. B145 heat stable protease resistance, but those partially sensitive same treatments. Our novel findings suggest dominant associated vagina, could strongly inhibit formation. repress ECE1) NRG1-dependent manner. Besides, highly worthwhile for probiotic investigation.

Language: Английский

Citations

134
Mechanism of Candida pathogenesis: revisiting the vital drivers DOI
Ifeanyi Elibe, Emeka Innocent Nweze

European Journal of Clinical Microbiology & Infectious Diseases, Journal Year: 2020, Volume and Issue: 39(10), P. 1797 - 1819

Published: May 6, 2020

Language: Английский

Citations

106
Applications of Silver Nanoparticles in Dentistry: Advances and Technological Innovation DOI Open Access
Clara Couto Fernandéz,

Ana Rita Sokolonski,

Maísa Santos Fonseca

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(5), P. 2485 - 2485

Published: March 2, 2021

Silver nanoparticles (AgNPs) have been successfully applied in several areas due to their significant antimicrobial activity against microorganisms. In dentistry, AgNP can be disinfection, prophylaxis, and prevention of infections the oral cavity. this work, use silver dentistry associated technological innovations was analyzed. The scientific literature searched using PubMed Scopus databases with descriptors related resulting 90 open-access articles. search for patents restricted A61K code (International Patent Classification), same descriptors, 206 patents. results found were ordered by dental specialties demonstrated incorporation AgNPs different dentistry. context, reaffirmed growth technology dominance USA pharmaceutical industry over product development. It could concluded that nanotechnology is a promising area applications.

Language: Английский

Citations

103
Candida glabrata: Pathogenicity and Resistance Mechanisms for Adaptation and Survival DOI Creative Commons
Yahaya Hassan, Shu Yih Chew, Leslie Thian Lung Than

et al.

Journal of Fungi, Journal Year: 2021, Volume and Issue: 7(8), P. 667 - 667

Published: Aug. 17, 2021

Candida glabrata is a yeast of increasing medical relevance, particularly in critically ill patients. It the second most isolated species associated with invasive candidiasis (IC) behind C. albicans. The attributed higher incidence primarily due to an increase acquired immunodeficiency syndrome (AIDS) population, cancer, and diabetic elderly population frequent use indwelling devices are also predisposing factors. This work aimed review various virulence factors that facilitate survival pathogenic IC. available published research articles related pathogenicity were retrieved reviewed from four credible databases, mainly Google Scholar, ScienceDirect, PubMed, Scopus. highlighted many glabrata, including adherence susceptible host surfaces, evading defences, replicative ageing, producing hydrolytic enzymes (e.g., phospholipases, proteases, haemolysins). infection initiation. Other virulent include iron regulation genetic mutations. Accordingly, biofilm production, tolerance high-stress environments, resistance neutrophil killings, development antifungal drugs, notably fluconazole other azole derivatives, reported. provided evident mechanisms ensuring its sustenance survival.

Language: Английский

Citations

103
The role of Lactobacillus species in the control of Candida via biotrophic interactions DOI Creative Commons
Isabella Zangl,

Ildiko-Julia Pap,

Christoph Aspöck

et al.

Microbial Cell, Journal Year: 2020, Volume and Issue: 7(1), P. 1 - 14

Published: Jan. 6, 2020

The role of Lactobacillus species in the control Candida via biotrophic interactions – Microbial communities have an important health and disease. spp. are ubiquitous commensals sometimes opportunistic fungal pathogens humans, colonizing mucosal surfaces genital, urinary, respiratory gastrointestinal tracts oral cavity. They mainly cause local infections immune competent individuals. However, case ineffective defense, may become a serious threat. part human microbiome natural competitors vaginal environment. Lactic acid, low pH other secreted metabolites environmental signals sensed by present microbiome. This review briefly discusses ternary interaction between host, with regard to (...)

Language: Английский

Citations

85
Candida albicans Interactions with Mucosal Surfaces during Health and Disease DOI Creative Commons
Spyridoula-Angeliki Nikou, Nessim Kichik,

Rhys Brown

et al.

Pathogens, Journal Year: 2019, Volume and Issue: 8(2), P. 53 - 53

Published: April 22, 2019

Flexible adaptation to the host environment is a critical trait that underpins success of numerous microbes. The polymorphic fungus Candida albicans has evolved persist in challenging niches human body. interaction C. with mucosal surface an essential prerequisite for fungal colonisation and epitomises complex interface between microbe host. exhibits adaptations healthy permit commensal surfaces without provoking overt immune response may lead clearance. Conversely, impaired fitness at enables pathogenic infiltration into underlying tissues, often devastating consequences. This review will summarise our current understanding interactions occur

Language: Английский

Citations

83
Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages DOI Creative Commons
Xionghui Ding, Hiroto Kambara,

Rongxia Guo

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Nov. 18, 2021

Candida albicans is the most common cause of fungal sepsis. Inhibition inflammasome activity confers resistance to polymicrobial and LPS-induced sepsis; however, signaling appears protect against C. infection, so inhibitors are not clinically useful for candidiasis. Here we show disruption GSDMD, a known target key pyroptotic cell death mediator, paradoxically alleviates candidiasis, improving outcomes survival Candida-infected mice. Mechanistically, hijacked canonical inflammasome-GSDMD axis-mediated pyroptosis promote their escape from macrophages, deploying hyphae candidalysin, pore-forming toxin expressed by hyphae. GSDMD inhibition alleviated candidiasis preventing macrophages while maintaining inflammasome-dependent but GSDMD-independent IL-1β production anti-fungal host defenses. This study demonstrates functions in Candida's immunity vitro vivo suggests that may be potential therapeutic albicans-induced

Language: Английский

Citations

69
Candida albicans can foster gut dysbiosis and systemic inflammation during HIV infection DOI Creative Commons
Silvère D. Zaongo, Jing Ouyang, Stéphane Isnard

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: Feb. 1, 2023

Candida albicans (C. albicans) is a ubiquitous fungal commensal component of the human microbiota, and under certain circumstances, such as during an immunocompromised state, it may initiate different types infection. Moreover, C. continuously reciprocally interacts with host immune system well other elements gut thus contributing significantly to both homeostasis immunity. People living HIV (PLWH), including those receiving antiretroviral therapy, are characterized by depletion CD4 + T-cells dysbiosis in their gut. colonization frequent PLWH, causing high prevalence morbidity. Gut barrier damage elevated levels microbial translocation also fairly common this population. Herein, we take closer look at reciprocity among albicans, HIV, system, throwing some light on complex interplay.

Language: Английский

Citations

33