Scarring the early-life microbiome: its potential life-long effects on human health and diseases DOI Creative Commons
Hyunji Park, N. Park, Ara Koh

et al.

BMB Reports, Journal Year: 2023, Volume and Issue: 56(9), P. 469 - 481

Published: Aug. 14, 2023

The gut microbiome is widely recognized as a dynamic organ with profound influence on human physiology and pathology.Extensive epidemiological longitudinal cohort studies have provided compelling evidence that disruptions in the early-life can long-lasting health implications.Various factors before, during, after birth contribute to shaping composition function of neonatal infant microbiome.While these alterations be partially restored over time, metabolic phenotypes may persist, necessitating research identify critical period for early intervention achieve phenotypic recovery beyond composition.In this review, we provide current understanding changes microbiota throughout life various affecting changes.Specifically, highlight impact disruption development diseases later discuss perspectives efforts recover from such disruptions.

Language: Английский

Impact of the mother's gut microbiota on infant microbiome and brain development DOI
Eman A. Mady, Ahmed S. Doghish, Walaa A. El‐Dakroury

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 150, P. 105195 - 105195

Published: April 24, 2023

Language: Английский

Citations

53
Gut–X axis DOI Creative Commons
Lin Xu, Yu Zhang, Xueyan Li

et al.

iMeta, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 1, 2025

Abstract Recent advances in understanding the modulatory functions of gut and microbiota on human diseases facilitated our focused attention contribution to pathophysiological alterations many extraintestinal organs, including liver, heart, brain, lungs, kidneys, bone, skin, reproductive, endocrine systems. In this review, we applied “gut–X axis” concept describe linkages between other organs discussed latest findings related axis,” underlying mechanisms potential clinical intervention strategies.

Language: Английский

Citations

2
Social and environmental transmission spread different sets of gut microbes in wild mice DOI Creative Commons
Aura Raulo, Paul‐Christian Bürkner, Genevieve E. Finerty

et al.

Nature Ecology & Evolution, Journal Year: 2024, Volume and Issue: 8(5), P. 972 - 985

Published: May 1, 2024

Abstract Gut microbes shape many aspects of organismal biology, yet how these key bacteria transmit among hosts in natural populations remains poorly understood. Recent work mammals has emphasized either transmission through social contacts or indirect environmental contact, but the relative importance different routes not been directly assessed. Here we used a novel radio-frequency identification-based tracking system to collect long-term high-resolution data on relationships, space use and microhabitat wild population mice ( Apodemus sylvaticus ), while regularly characterizing their gut microbiota with 16S ribosomal RNA profiling. Through probabilistic modelling resulting data, identify positive statistically distinct signals transmission, captured by networks overlap home ranges, respectively. Strikingly, microorganisms biological attributes drove signals. While network effect was driven anaerobic bacteria, shared most influenced aerotolerant spore-forming bacteria. These findings support prediction that contact is important for transfer low oxygen tolerance, those can tolerate form spores may be able indirectly environment. Overall, results suggest spread biologically members mammalian microbiota.

Language: Английский

Citations

13
Daily skin-to-skin contact alters microbiota development in healthy full-term infants DOI Creative Commons
Henrik Eckermann, Jennifer L. Meijer, Kelly H. M. Cooijmans

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 10, 2024

The gut microbiota is vital for human body development and function. Its in early life influenced by various environmental factors. In this randomized controlled trial, the was obtained as a secondary outcome measure study on effects of one hour daily skin-to-skin contact (SSC) five weeks healthy full-term infants. Specifically, we studied alpha/beta diversity, volatility, maturation, bacterial gut-brain-axis-related functional abundances assessed thrice first year. Pregnant Dutch women (n = 116) were randomly assigned to SSC or care-as-usual groups. group participants engaged from birth age. Stool samples collected at two, five, 52 V4 region sequenced. We observed significant differences composition, abundances, predicted pathways between exhibited lower volatility during infancy. Microbiota maturation slower year our results suggested that breastfeeding duration may have partially mediated relation. Our findings provide evidence postpartum influence development. Replication necessary validate generalize these results. Future studies should include direct stress measurements extend sampling beyond investigate mechanism research SSC's impact long-term trajectories.

Language: Английский

Citations

12
Boosting microbiome science worldwide could save millions of children’s lives DOI Open Access
Hilary P. Browne, Najeeha Talat Iqbal, Majdi Osman

et al.

Nature, Journal Year: 2024, Volume and Issue: 625(7994), P. 237 - 240

Published: Jan. 8, 2024

Language: Английский

Citations

11
Primary succession of Bifidobacteria drives pathogen resistance in neonatal microbiota assembly DOI Creative Commons
Yan Shao, Cristina García-Mauriño, Simon Clare

et al.

Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(10), P. 2570 - 2582

Published: Sept. 6, 2024

Language: Английский

Citations

10
Maternal Pre- and Postnatal Stress and Maternal and Infant Gut Microbiota Features. DOI Creative Commons
Henrik Eckermann,

Hellen Lustermans,

Katariina Pärnänen

et al.

Psychoneuroendocrinology, Journal Year: 2025, Volume and Issue: 172, P. 107273 - 107273

Published: Jan. 2, 2025

Maternal stress can have short and long term adverse (mental) health effects for the mother her child. Previous evidence suggests that gut microbiota may be a potential mediator moderator of via various pathways. This study explored maternal trajectory during pregnancy as well association between pre- postnatal features infant after pregnancy. In line with previous research, we hypothesized would positively related to volatility infants highly stressed mothers show relative increase in Proteobacteria decrease Bifidobacterium. We collected stool samples at 18 32 weeks 8 months postpartum. Infant stools were obtained 2, 6 12 All analyzed using shotgun metagenome sequencing. also several measures (self-reported depression, anxiety, stress, hair cortisol cortisone), most same time points samples. Our data indicated does not undergo drastic changes from second third trimester but postpartum differs significantly prenatal microbiota. Furthermore, identified associations different including positive negative alpha diversity, beta diversity individual microbial phyla species abundances. Also, composite score, perceived score log-ratio cortisone all associated volatility. provides is both Collectively, this studies indicate uniformly associate features. Instead, are point specific. Regarding volatility, consistently found warrants future research investigating link more depth.

Language: Английский

Citations

1
Altered microbiome and metabolome profiling in fearful companion dogs: An exploratory study DOI Creative Commons
Luigi Sacchettino, Michele Costanzo, Iolanda Veneruso

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0315374 - e0315374

Published: Jan. 15, 2025

Behavioral dysfunctions in dogs represent one of the main social concerns, since they can endanger animals and human-dog relationship. Together with trigger stimulus (human, animal, place, scent, auditory stimuli, objects), experience stressful conditions, either multiple settings or unique situations, more often turning into generalized fear. Such a dysfunctional behavior be associated genetic susceptibility, environmental factors, traumatic experiences, medical conditions. The available therapy, based on approaches, management, neurochemical manipulation, through nutrition, supplements, medicines, pheromones, mainstays treatments currently accessible. Growing evidence humans highlight importance gut-brain axis modulation brain physiology as well. Here, taking advantage next generation sequencing approach, we sought to investigate potential connection between gut microbiota microbiome suffering from fear (n = 8), when compared healthy subjects who all lived different families. Faecal evaluation showed differential abundance taxa related Proteobacteria Firmicutes Phyla, case control dogs. Moreover, serum metabolomics documented significant alterations molecules GABA glutamate neurotransmission patients, well bile acids metabolism. Overall, our preliminary integrated investigations highlighted an intriguing role for microbiome-metabolome network, allowing further unveil pathophysiology relational issues companion paving way effective therapeutical approaches.

Language: Английский

Citations

1
The influence of pre- and postnatal exposure to air pollution and green spaces on infant’s gut microbiota: results from the MAMI birth cohort study DOI Creative Commons
Adrià Cruells, Raúl Cabrera‐Rubio, Mariona Bustamante

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 257, P. 119283 - 119283

Published: June 1, 2024

Animal and human studies indicate that exposure to air pollution natural environments might modulate the gut microbiota, but epidemiological evidence is very scarce.

Language: Английский

Citations

7
Gut Microbiota and Behavioural Issues in Production, Performance, and Companion Animals: A Systematic Review DOI Creative Commons
Bonnie Homer,

Jackson Judd,

Manijeh Mohammadi‐Dehcheshmeh

et al.

Animals, Journal Year: 2023, Volume and Issue: 13(9), P. 1458 - 1458

Published: April 25, 2023

The literature has identified poor nutrition as the leading factor in manifestation of many behavioural issues animals, including aggression, hyperalertness, and stereotypies. Literature focused on all species interest consistently reported that although there were no significant differences richness specific bacterial taxa microbiota individual subjects with abnormal behaviour (termed alpha diversity), was variability diversity between these compared to controls beta diversity). As seen humans mental disorders, animals exhibiting often have an enrichment pro-inflammatory lactic acid-producing bacteria a reduction butyrate-producing bacteria. It is evident from association exists gut (and by extension, concurrent production microbial metabolites) phenotypes across various species, pigs, dogs, horses. Similar population changes are also human health patients. However, insufficient data identify this cause or effect. This review provides testable hypotheses for future research establish causal relationships offering promising potential development novel therapeutic and/or preventative interventions aimed at restoring healthy gut-brain-immune axis mitigate and, turn, improve health, performance, animals.

Language: Английский

Citations

13