Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 2, 2024

Abstract Early development of the gut ecosystem is crucial for lifelong health. While infant bacterial communities have been studied extensively, virome remains under-explored. To study over time and factors that shape it, we longitudinally assess composition viruses their hosts in 30 women during after pregnancy 32 infants first year life. Using shotgun metagenomic sequencing applied to dsDNA extracted from Virus-Like Particles (VLPs) bacteria, generate 205 VLP metaviromes 322 total metagenomes. With this data, show while maternal stable late birth, dynamic Notably, viromes contain a higher abundance active temperate phages compared viromes, which decreases Moreover, feeding mode place delivery influence infants. Lastly, provide evidence co-transmission viral strains mothers infants, demonstrating acquire some mother’s gut.

Language: Английский

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Microbiota during pregnancy and early life: role in maternal−neonatal outcomes based on human evidence

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Aug. 19, 2024

Here, we explored the vast potential of microbiome-based interventions in preventing and managing non-communicable diseases including obesity, diabetes, allergies, celiac disease, inflammatory bowel diseases, malnutrition, cardiovascular across different life stages. We discuss intricate relationship between microbiome emphasizing on "window opportunity" for microbe–host interactions during first years after birth. Specific biotics also live biotherapeutics fecal microbiota transplantation emerge as pivotal tools precision medicine, acknowledging "one size doesn't' fit all" aspect. Challenges implementation underscore need advanced technologies, scientific transparency, public engagement. Future perspectives advocate understanding maternal−neonatal microbiome, exploring maternal exposome delving into human milk's role establishment restoration infant its influence over health disease. An integrated approach, employing multi-omics accounting inter-individual variance composition function appears central to unleash full early-life revolutionizing healthcare.

Language: Английский

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Host–gut microbiota interactions during pregnancy

Evolution Medicine and Public Health, Journal Year: 2024, Volume and Issue: 12(1), P. 7 - 23

Published: Jan. 1, 2024

Abstract Mammalian pregnancy is characterized by a well-known suite of physiological changes that support fetal growth and development, thereby positively affecting both maternal offspring fitness. However, mothers also experience trade-offs between current future reproductive success, responses to these can result in mother–offspring fitness conflicts. Knowledge the mechanisms through which operate, as well contexts they critical for understanding evolution reproduction. Historically, hormonal during have been thought play pivotal role conflicts since directly indirectly influence metabolism, immunity, other aspects development. recent research suggests gut microbiota may an important role. Here, we create foundation exploring this constructing mechanistic model linking hormones, immunity metabolism microbiota. We posit marked hormones alter microbiome composition function via impacts on immune system. The then feeds back metabolism. dynamics are likely be involved mediating different health pregnancy. predict interactions describe vary across populations response environments. Moving forward, empirical studies combine microbial functional data with outcomes infants will allow us test evolutionary implications gestational microbiota, enriching our ecology physiology.

Language: Английский

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Placental Epigenome Impacts Fetal Development: Effects of Maternal Nutrients and Gut Microbiota

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1860 - 1860

Published: June 13, 2024

Evidence is emerging on the role of maternal diet, gut microbiota, and other lifestyle factors in establishing lifelong health disease, which are determined by transgenerationally inherited epigenetic modifications. Understanding mechanisms may help identify novel biomarkers for gestation-related exposure, burden, or disease risk. Such essential developing tools early detection risk exposure levels. It necessary to establish an threshold due nutrient deficiencies environmental that can result clinically relevant alterations modulate risks fetus. This narrative review summarizes latest updates roles nutrients (n-3 fatty acids, polyphenols, vitamins) microbiota placental epigenome its impacts fetal brain development. unravels potential functional targeted intervention ensure optimal development performance later life.

Language: Английский

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Microbiota-targeted interventions and clinical implications for maternal-offspring health: An umbrella review of systematic reviews and meta-analyses of randomised controlled trials

Journal of Global Health, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 13, 2024

Microbes in the human body are determinants of life-long health and disease. Microbiome acquisition starts utero matures during early childhood through breastfeeding. However, maternal gut dysbiosis affects maternal-offspring microbiome interplay. Lines evidence on dysbiosis-targeted interventions their effect inconsistent inconclusive. Therefore, this study summarised studies to identify most common microbiota-targeted intervention pregnancy lactation comprehensively evaluate its effects offspring health.

Language: Английский

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Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 935 - 935

Published: March 24, 2024

Pregnancy alters many physiological systems, including the maternal gut microbiota. Diet is a key regulator of this system and can alter host immune to promote inflammation. Multiple perinatal disorders have been associated with inflammation, metabolic alterations, microbial dysbiosis, gestational diabetes mellitus, pre-eclampsia, preterm birth, mood disorders. However, effects high-inflammatory diets on microbiota during pregnancy yet be fully explored. We aimed address gap using system-based approach characterize associations among dietary inflammatory potential, measure diet quality, microbiome pregnancy. Forty-seven pregnant persons were recruited prior 16 weeks gestation. Participants completed food frequency questionnaire (FFQ) provided fecal samples. Dietary potential was assessed Inflammatory Index (DII) from FFQ data. Fecal samples analyzed 16S rRNA amplicon sequencing. Differential taxon abundances respect DII score identified, predicted PICRUSt2. decreased vitamin mineral intake dysbiotic structure metabolism. Gut compositional differences revealed decrease in short-chain fatty acid producers such as Faecalibacterium, an increase B12 synthesis, methylglyoxal detoxification, galactose metabolism, multidrug efflux systems individuals increased scores. reduction consumption vitamins minerals dysregulation.

Language: Английский

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The Role of Gut Microbiota in the Onset and Progression of Obesity and Associated Comorbidities

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12321 - 12321

Published: Nov. 16, 2024

Obesity, a global public health problem, is constantly increasing, so the concerns in preventing and combating it are increasingly focused on intestinal microbiota. It was found that microbiota different lean people compared to obese individuals, but exact mechanisms by which energy homeostasis influenced still incompletely known. Numerous studies show involvement of certain bacterial species promoting obesity associated diseases such as diabetes, hypertension, cancer, etc. Our aim summarize main findings regarding influence several factors lifestyle changes, including diet bariatric surgery, diversity gut individuals. The second purpose this paper investigate potential effect various modulation techniques ameliorating its comorbidities. A literature search conducted using PubMed database, identifying articles published between 2019 2024. Most identified suggest generally with alterations microbiome decreased microbial diversity, an increased Firmicutes-to-Bacteroidetes ratio, SCFAs levels. also indicate could represent novel strategy treating related metabolic diseases. Although some (e.g., inflammation or hormonal regulation) already considered powerful connection development, further research needed enhance knowledge particular topic.

Language: Английский

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Composition of the fecal, vaginal and colostrum microbiotas of dams at parturition and their relationship with neonatal outcomes in dogs

Animal Microbiome, Journal Year: 2025, Volume and Issue: 7(1)

Published: March 6, 2025

Microbial seeding in early life is critical for the host's short- and long-term health, mother first source of bacteria newborn. The objective this study was to characterize maternal fecal, vaginal, colostral microbiotas canine species one day after parturition evaluate relationship between microbial profiles 36 dams neonatal outcomes 284 newborns. part revealed presence 2 3 clusters on basis core microbiota dams. Among these three microbiotas, only vaginal microbiome found be associated with outcomes. Compared those other clusters, females Cluster 1, lowest stillbirth mortality ratios, presented a greater abundance Moraxellaceae their microbiota; 2, Pasteurellaceae, mostly from Haemophilus genus; (with highest ratios), Enterobacteriaceae, E. coli. Moreover, significantly lower richness according Shannon index than did clusters. This underscores strong association microbiota, particularly newborn health. results call further research gain deeper understanding optimal composition ways modulate it improve

Language: Английский

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Investigating the Microbiome in Relation to Mental Distress Across Two Points of Pregnancy: Data from USA and Swedish Cohorts

Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: unknown, P. 100453 - 100453

Published: Jan. 1, 2025

Language: Английский

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Developmental inequity and the impact of pesticide exposure on gut and brain health in developing nations – a Brazilian perspective

Humanities and Social Sciences Communications, Journal Year: 2025, Volume and Issue: 12(1)

Published: Feb. 1, 2025

Language: Английский

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