Introduction to the human gut microbiota

Biochemical Journal, Journal Year: 2017, Volume and Issue: 474(11), P. 1823 - 1836

Published: May 16, 2017

The human gastrointestinal (GI) tract harbours a complex and dynamic population of microorganisms, the gut microbiota, which exert marked influence on host during homeostasis disease. Multiple factors contribute to establishment microbiota infancy. Diet is considered as one main drivers in shaping across life time. Intestinal bacteria play crucial role maintaining immune metabolic protecting against pathogens. Altered bacterial composition (dysbiosis) has been associated with pathogenesis many inflammatory diseases infections. interpretation these studies relies better understanding inter-individual variations, heterogeneity communities along GI tract, functional redundancy need distinguish cause from effect states dysbiosis. This review summarises our current development its impact integrity health, underlying for mechanistic focusing host–microbe interactions.

Language: Английский

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An insight into gut microbiota and its functionalities

Cellular and Molecular Life Sciences, Journal Year: 2018, Volume and Issue: 76(3), P. 473 - 493

Published: Oct. 13, 2018

Language: Английский

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Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

Proceedings of the National Academy of Sciences, Journal Year: 2017, Volume and Issue: 114(40), P. 10713 - 10718

Published: Sept. 11, 2017

Significance We have experimentally investigated the immunoregulatory effects of human gut microbiota in multiple sclerosis (MS). identified specific bacteria that are associated with MS and demonstrated these regulate T lymphocyte-mediated adaptive immune responses contribute to proinflammatory environment vitro vivo. Thus, our results expand knowledge microbial regulation immunity may provide a basis for development microbiome-based therapeutics autoimmune diseases.

Language: Английский

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Gut-microbiota-targeted diets modulate human immune status

Cell, Journal Year: 2021, Volume and Issue: 184(16), P. 4137 - 4153.e14

Published: July 12, 2021

Language: Английский

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Profile of the gut microbiota of adults with obesity: a systematic review

European Journal of Clinical Nutrition, Journal Year: 2020, Volume and Issue: 74(9), P. 1251 - 1262

Published: March 30, 2020

Language: Английский

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Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis

Microbiome, Journal Year: 2021, Volume and Issue: 9(1)

Published: Sept. 7, 2021

Abstract Background Alteration of the gut microbiota may contribute to development inflammatory bowel disease (IBD). Epigallocatechin-3-gallate (EGCG), a major bioactive constituent green tea, is known be beneficial in IBD alleviation. However, it unclear whether exerts an effect when EGCG attenuates IBD. Results We first explored oral or rectal delivery on DSS-induced murine colitis. Our results revealed that anti-inflammatory and colonic barrier integrity were enhanced by oral, but not rectal, EGCG. observed distinct EGCG-mediated alteration microbiome increasing Akkermansia abundance butyrate production. Next, we demonstrated pre-supplementation induced similar outcomes administration. Prophylactic attenuated colitis significantly enriched short-chain fatty acids (SCFAs)-producing bacteria such as SCFAs production mice. To validate these discoveries, performed fecal transplantation (FMT) sterile filtrate (SFF) inoculate DSS-treated Microbiota from EGCG-dosed mice alleviated over control SFF shown superiorly integrity, also SCFAs. Collectively, attenuation suggests intimate involvement SCFAs-producing , SCFAs, which was further prophylaxis FMT. Conclusions This study provides data indicating ameliorated inflammation microbiota-dependent manner. findings provide novel insights into remission potential modulator for prevent treat

Language: Английский

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Polysaccharide Degradation by the Intestinal Microbiota and Its Influence on Human Health and Disease

Journal of Molecular Biology, Journal Year: 2016, Volume and Issue: 428(16), P. 3230 - 3252

Published: July 6, 2016

Language: Английский

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Development of a gut microbe–targeted nonlethal therapeutic to inhibit thrombosis potential

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(9), P. 1407 - 1417

Published: July 26, 2018

Language: Английский

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The gut microbiota influences anticancer immunosurveillance and general health

Nature Reviews Clinical Oncology, Journal Year: 2018, Volume and Issue: 15(6), P. 382 - 396

Published: April 10, 2018

Language: Английский

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Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function

PLoS ONE, Journal Year: 2017, Volume and Issue: 12(3), P. e0173004 - e0173004

Published: March 1, 2017

Gut barrier function is key in maintaining a balanced response between the host and its microbiome. The microbiota can modulate changes gut as well metabolic inflammatory responses. This highly complex system involves numerous microbiota-derived factors. symbiont Akkermansia muciniphila positively correlated with lean phenotype, reduced body weight gain, amelioration of responses restoration by modulation mucus layer thickness. However, molecular mechanisms behind immunological regulatory properties are unexplored. Herein, we identify abundant outer membrane pili-like protein A. MucT that directly involved immune regulation enhancement trans-epithelial resistance. purified Amuc_1100 enrichments containing all associated proteins induced production specific cytokines through activation Toll-like receptor (TLR) 2 TLR4. mainly leads to high levels IL-10 similar those other beneficial suppressive microorganisms such Faecalibacterium prausnitzii A2-165 Lactobacillus plantarum WCFS1. Together these results indicate composition particularly newly identified homeostasis at mucosa, improvement function.

Language: Английский

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