Redox Balance in Cancer in the Context of Tumor Prevention and Treatment DOI Creative Commons
Paweł Sutkowy, Przemysław Czeleń

Biomedicines, Journal Year: 2025, Volume and Issue: 13(5), P. 1149 - 1149

Published: May 9, 2025

Malignant neoplasms constitute a substantial health concern for the human population, currently ranking as second leading cause of mortality worldwide. In 2022, approximately 10 million deaths were attributable to cancer, and projections estimate that this number will rise 35 in 2050. Consequently, development effective cancer treatments prevention strategies remains primary focus medical research. context, impacts on redox balance are being considered. The objective study was present current knowledge oxidation reduction processes cancer. This review discloses intricate multifaceted interplay oxidoreductive systems during carcinogenesis, which engenders discordant findings domain tumor treatment. also examines controversies surrounding use antioxidants, including their impact other therapeutic interventions. offers comprehensive overview existing subject, concluding personalized precise anticancer therapies targeting can serve both diagnostic tools.

Language: Английский

Targeting ROS in cancer: rationale and strategies DOI
Christophe Glorieux, Shihua Liu, Dunyaporn Trachootham

et al.

Nature Reviews Drug Discovery, Journal Year: 2024, Volume and Issue: 23(8), P. 583 - 606

Published: July 9, 2024

Language: Английский

Citations

133
Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications DOI Creative Commons
Qian Zhong,

Xina Xiao,

Yijie Qiu

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(3)

Published: May 2, 2023

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent bonds on backbones amino acid side chains proteins and expand diversity proteins, which provides basis for emergence organismal complexity. To date, more than 650 types protein modifications, such as most well-known phosphorylation, ubiquitination, glycosylation, methylation, SUMOylation, short-chain long-chain acylation redox irreversible have been described, inventory is still increasing. By changing conformation, localization, activity, stability, charges, interactions with other biomolecules, PTMs ultimately alter phenotypes biological processes cells. The homeostasis important human health. Abnormal may cause changes in properties loss functions, are closely related occurrence development various diseases. In this review, we systematically introduce characteristics, regulatory mechanisms, functions health addition, therapeutic prospects diseases by targeting associated enzymes also summarized. This work will deepen understanding promote discovery diagnostic prognostic markers drug targets

Language: Английский

Citations

119
Oxidative Stress in Age-Related Neurodegenerative Diseases: An Overview of Recent Tools and Findings DOI Creative Commons
Dimitris Korovesis, Teresa Rubio‐Tomás, Nektarios Tavernarakis

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(1), P. 131 - 131

Published: Jan. 5, 2023

Reactive oxygen species (ROS) have been described to induce a broad range of redox-dependent signaling reactions in physiological conditions. Nevertheless, an excessive accumulation ROS leads oxidative stress, which was traditionally considered as detrimental for cells and organisms, due the damage they cause biomolecules. During ageing, elevated levels result damaged proteins, may exhibit altered enzymatic function or physical properties (e.g., aggregation propensity). Emerging evidence also highlights relationship between stress age-related pathologies, such protein misfolding-based neurodegenerative diseases Parkinson’s (PD), Alzheimer’s (AD) Huntington’s (HD) diseases). In this review we aim introduce role physiology pathology then focus on state-of-the-art techniques available detect quantify oxidized proteins live vivo, providing guide those aiming characterize ageing diseases. Lastly, discuss recently published data neurological disorders.

Language: Английский

Citations

75
S100A8 and S100A9 in Cancer DOI
Yu Chen,

Yuzhen Ouyang,

Zhixin Li

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(3), P. 188891 - 188891

Published: March 29, 2023

Language: Английский

Citations

69
A bioinformatics analysis, pre-clinical and clinical conception of autophagy in pancreatic cancer: Complexity and simplicity in crosstalk DOI Creative Commons
Milad Ashrafizadeh, Wei Zhang, Rongjun Zou

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 194, P. 106822 - 106822

Published: June 17, 2023

Pancreatic cancer (PC) is a serious gastrointestinal tract disease for which the 5-year survival rate less than 10%, even in developed countries such as USA. The genomic profile alterations and dysregulated biological mechanisms commonly occur PC. Macroautophagy/autophagy cell death process that maintained at basal level physiological conditions, whereas its often changes during tumorigenesis. function of autophagy human cancers dual can be oncogenic onco-suppressor. Autophagy potent controller tumorigenesis supportive PC escalates growth cells suppression mediate death. also determines metastasis cells, it control EMT affecting migration. Moreover, starvation hypoxia stimulate glycolysis, glycolysis induction mediated by enhancing Furthermore, protective stimulates drug resistance gemcitabine inhibition enhance radiosensitivity. degrade MHC-I to immune evasion regulates polarization macrophages tumor microenvironment. Modulation activity provided silibinin, ursolic acid, chrysin huaier treatment Non-coding RNAs are controllers improve therapy response patients. mitophagy shows dysregulation PC, proliferation cells. Therefore, bioinformatics analysis demonstrates autophagy-related proteins genes biomarkers.

Language: Английский

Citations

65
The pleiotropic functions of reactive oxygen species in cancer DOI
Katherine Wu, Ahmed E. El Zowalaty, Volkan I. Sayin

et al.

Nature Cancer, Journal Year: 2024, Volume and Issue: 5(3), P. 384 - 399

Published: March 22, 2024

Language: Английский

Citations

61
Reactive oxygen species (ROS), oxygen radicals and antioxidants: Where are we now, where is the field going and where should we go? DOI
Barry Halliwell

Biochemical and Biophysical Research Communications, Journal Year: 2022, Volume and Issue: 633, P. 17 - 19

Published: Nov. 4, 2022

Language: Английский

Citations

48
Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma DOI Creative Commons
Shailendra K. Gautam, Surinder K. Batra, Maneesh Jain

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: July 24, 2023

Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC), contributing to early metastasis and poor patient survival. Compared the localized tumors, current standard-of-care therapies have failed improve survival patients with metastatic PDAC, that necessecitates exploration novel therapeutic approaches. While immunotherapies such as immune checkpoint blockade (ICB) vaccines emerged promising treatment modalities in certain cancers, limited responses been achieved PDAC. Therefore, specific mechanisms regulating response immunotherapy must be explored. The immunosuppressive microenvironment driven by oncogenic mutations, tumor secretome, non-coding RNAs, microbiome persists throughout PDAC progression, allowing neoplastic cells grow locally metastasize distantly. escaping host surveillance are unique molecular, immunological, metabolic characteristics. Following chemokine exosomal guidance, these organ-specific pre-metastatic niches (PMNs) constituted local resident cells, stromal fibroblasts, suppressive metastasis-associated macrophages, neutrophils, myeloid-derived suppressor cells. differs from primary tumors cell composition, functionality, metabolism. Thus far, multiple molecular pathways, distinct identified dampen effector functions, confounding This review describes major immunoregulatory pathways contribute progression limit outcomes Overall, we highlight vulnerabilities attributable factors discuss whether targeting immunological "hot spots" could immunotherapies.

Language: Английский

Citations

39
Targeting methionine metabolism in cancer: opportunities and challenges DOI
Peng Bin, Chuanlong Wang, Hangchao Zhang

et al.

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(5), P. 395 - 405

Published: April 5, 2024

Language: Английский

Citations

15
Emerging mechanisms and promising approaches in pancreatic cancer metabolism DOI Creative Commons
Hao Wu,

Mengdi Fu,

Mengwei Wu

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(8)

Published: Aug. 1, 2024

Abstract Pancreatic cancer is an aggressive with a poor prognosis. Metabolic abnormalities are one of the hallmarks pancreatic cancer, and cells can adapt to biosynthesis, energy intake, redox needs through metabolic reprogramming tolerate nutrient deficiency hypoxic microenvironments. use glucose, amino acids, lipids as maintain malignant growth. Moreover, they also metabolically interact in tumour microenvironment change cell fate, promote progression, even affect immune responses. Importantly, changes at body level deserve more attention. Basic research clinical trials based on targeted therapy or combination other treatments full swing. A comprehensive in-depth understanding regulation will not only enrich mechanisms disease progression but provide inspiration for new diagnostic therapeutic approaches.

Language: Английский

Citations

13