Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 97, P. 12 - 20
Published: Nov. 4, 2023
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Aug. 12, 2024
Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.
Language: Английский
Citations
87
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Sept. 25, 2024
Language: Английский
Citations
22
Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(3)
Published: March 1, 2024
Abstract Background Cancer is a thorny problem which cannot be conquered by mankind at present and recent researchers have put their focus on tumor microenviroment. Neutrophils, the prominent leukocytes in peripheral blood that accumulate tumours, serves as frontline cells response to tumour progression owing rapid development of micro biotechnology. Hence, targeted therapy with these neutrophils has made targeting treatment promising field cancer therapy. Main body We broadly summarise some studies phenotypes functions tumour‐associated well unique web‐like products play role progression—neutrophil extracellular traps—and interactions between microenvironment. Moreover, several therapeutic progress provided potential strategies for cancer. Conclusion This review aims offer holistic perspective interventions further inspire more researches therapies.
Language: Английский
Citations
15
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: July 18, 2024
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterized by late diagnosis, rapid progression, and high mortality rate. Its complex biology, dense, stromal tumor environment with an immunosuppressive milieu, contributes to resistance against standard treatments like chemotherapy radiation. This comprehensive review explores the dynamic role of microbiome in modulating efficacy outcomes PDAC. It delves into microbiome's impact on drug metabolism resistance, interaction between microbial elements, drugs, human biology. We also highlight significance specific bacterial species enzymes influencing action immune response microenvironment. Cutting-edge methodologies, including artificial intelligence, low-biomass analysis patient-derived organoid models, are discussed, offering insights nuanced interactions microbes cells. The potential microbiome-based interventions as adjuncts conventional PDAC paving way for personalized therapy approaches. synthesizes recent research provide in-depth understanding how affects efficacy. focuses elucidating key mechanisms identifying existing knowledge gaps. Addressing these gaps crucial enhancing medicine refining treatment strategies, ultimately improving patient outcomes.
Language: Английский
Citations
9
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 730 - 730
Published: Jan. 16, 2025
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis, primarily due to its immunosuppressive tumor microenvironment (TME), which contributes treatment resistance. Recent research shows that the microbiome, including microbial communities in oral cavity, gut, bile duct, and intratumoral environments, plays a key role PDAC development, imbalances (dysbiosis) promoting inflammation, progression, therapy resistance, side effects. Microbial metabolites can also affect immune cells, especially natural killer (NK) are vital for surveillance, response treatment-related Dysbiosis NK cell function, leading resistance We propose combined biomarker approach, integrating microbiome composition profiles, help predict effects, enabling more personalized therapies. This review examines how dysbiosis dysfunction discusses strategies (e.g., antibiotics, probiotics, vaccines) modulate enhance function. Targeting could activity, improve effectiveness of treatments, reduce However, further needed develop unified cell–microbiome interaction-based biomarkers precise effective patient outcomes.
Language: Английский
Citations
1
Cancers, Journal Year: 2024, Volume and Issue: 16(4), P. 794 - 794
Published: Feb. 15, 2024
Advances in our understanding of pancreatic ductal adenocarcinoma (PDAC) and its tumor microenvironment (TME) have the potential to transform treatment for hundreds thousands patients who are diagnosed each year. Whereas clinical assessment cancer cell genetics has grown increasingly sophisticated personalized, current protocols evaluate TME lagged, despite evidence that can be heterogeneous within between patients. Here, we outline PDAC diagnosis management, review novel biomarkers, highlight opportunities challenges when evaluating as prepare translate emerging TME-directed therapies clinic.
Language: Английский
Citations
7
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: June 27, 2024
Exosomes, as a class of small extracellular vesicles closely related to the biological behavior various types tumors, are currently attracting research attention in cancer diagnosis and treatment. Regarding diagnosis, stability their membrane structure wide distribution body fluids render exosomes promising biomarkers. It is expected that exosome-based liquid biopsy will become an important tool for tumor future. For treatment, exosomes, “golden communicators” between cells, can be designed deliver different drugs, aiming achieve low-toxicity low-immunogenicity targeted delivery. Signaling pathways exosome contents also used safer more effective immunotherapy against tumors. Exosomes derived from range sources, exhibit characteristics well clinical application advantages therapies. In this review, we analyzed main sources have great potential broad prospects therapy. Moreover, compared therapeutic advantages, providing new ideas exosomes.
Language: Английский
Citations
6
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: July 9, 2024
The gut microbiome plays a significant role in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC), influencing oncogenesis, immune responses, and treatment outcomes. Studies have identified microbial species like Porphyromonas gingivalis Fusobacterium nucleatum, that promote PDAC progression through various mechanisms. Additionally, affects cell activation response to immunotherapy, including checkpoint inhibitors CAR-T therapy. Specific microbes their metabolites play effectiveness (ICIs). Alterations can either enhance or diminish responses PD-1/PD-L1 CTLA-4 blockade bacterial trimethylamine N-oxide (TMAO) lipopolysaccharide (LPS) impact antitumor immunity, offering potential targets augment immunotherapy responses. Modulating fecal microbiota transplantation, probiotics, prebiotics, dietary changes, antibiotics shows promise treatment, although outcomes are highly variable. Dietary modifications, particularly high-fiber diets specific fat consumption, influence composition cancer risk. Combining microbiome-based therapies with existing treatments holds for improving therapy outcomes, but further research is needed optimize effectiveness.
Language: Английский
Citations
6
Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217350 - 217350
Published: Nov. 1, 2024
Pancreatic cancer remains one of the most challenging malignancies to treat due its late-stage diagnosis, aggressive progression, and high resistance existing therapies. This review examines latest advancements in early detection, therapeutic strategies, with a focus on emerging biomarkers, tumor microenvironment (TME) modulation, integration artificial intelligence (AI) data analysis. We highlight promising including microRNAs (miRNAs) circulating DNA (ctDNA), that offer enhanced sensitivity specificity for early-stage diagnosis when combined multi-omics panels. A detailed analysis TME reveals how components such as cancer-associated fibroblasts (CAFs), immune cells, extracellular matrix (ECM) contribute therapy by creating immunosuppressive barriers. also discuss interventions target these components, aiming improve drug delivery overcome evasion. Furthermore, AI-driven analyses are explored their potential interpret complex data, enabling personalized treatment strategies real-time monitoring response. conclude identifying key areas future research, clinical validation regulatory frameworks AI applications, equitable access innovative comprehensive approach underscores need integrated, outcomes pancreatic cancer.
Language: Английский
Citations
6
Biological Procedures Online, Journal Year: 2024, Volume and Issue: 26(1)
Published: May 27, 2024
Abstract Exosomes are increasingly recognized as important mediators of intercellular communication in cancer biology. can be derived from cells well cellular components tumor microenvironment. After secretion, the exosomes carrying a wide range bioactive cargos ingested by local or distant recipient cells. The released act through variety mechanisms to elicit multiple biological effects and impact most if not all hallmarks cancer. Moreover, owing their excellent biocompatibility capability being easily engineered modified, currently exploited promising platform for targeted therapy. In this review, we first summarize current knowledge roles risk etiology, initiation progression cancer, underlying molecular mechanisms. aptamer-modified exosome therapy is then briefly introduced. We also discuss future directions emerging biology perspective
Language: Английский
Citations
5