Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155374 - 155374
Published: May 29, 2024
Language: Английский
Acta Pharmaceutica Sinica B, Journal Year: 2020, Volume and Issue: 11(2), P. 340 - 354
Published: Oct. 10, 2020
Enormous studies have corroborated that long non-coding RNAs (lncRNAs) extensively participate in crucial physiological processes such as metabolism and immunity, are closely related to the occurrence development of tumors, cardiovascular diseases, nervous system disorders, nephropathy, other diseases. The application lncRNAs biomarkers or intervention targets can provide new insights into diagnosis treatment This paper has focused on emerging research pharmacological reviewed transition from role disease coding acting drug candidates, including current status progress preclinical research. Cutting-edge strategies for lncRNA modulation been summarized, sources lncRNA-related drugs, genetic technology small-molecule compounds, delivery methods. clinical trials lncRNA-targeting drugs is also discussed. information will form a latest updated reference lncRNA-based drugs.
Language: Английский
Citations
381
Cells, Journal Year: 2020, Volume and Issue: 9(7), P. 1574 - 1574
Published: June 28, 2020
MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for silencing and post-transcriptional regulation gene expression. They can mediate fine-tuned crosstalk among coding molecules sharing miRNA response elements (MREs). In suitable environment, both be targeted by the same miRNAs indirectly regulate each other competing them. These RNAs, otherwise known as endogenous RNAs (ceRNAs), lead to an additional regulatory layer, where find new significance. The miRNA-mediated interplay different types has been observed in many contexts. analyses ceRNA networks cancer pathologies, well physiological conditions, provide opportunities interpreting omics data field personalized medicine. development novel computational tools, providing putative predictions interactions, is rapidly growing interest. this review, I discuss present current knowledge mechanism its implications broad spectrum such cardiovascular or autoimmune diseases, cancers neurodegenerative disorders.
Language: Английский
Citations
149
Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(19), P. 7167 - 7199
Published: Jan. 1, 2020
Targeting RNAs with small molecules, a new frontier in drug discovery and development.
Language: Английский
Citations
142
Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12
Published: Aug. 17, 2022
Cancer is one of the most frequently diagnosed malignant diseases worldwide, posing a serious, long-term threat to patients’ health and life. Systemic chemotherapy remains first-line therapeutic approach for recurrent or metastatic cancer patients after surgery, with potential effectively extend patient survival. However, development drug resistance seriously limits clinical efficiency ultimately results in treatment failure death. A large number studies have shown that non-coding RNAs (ncRNAs), particularly microRNAs, long RNAs, circular are widely involved regulation resistance. Their dysregulation contributes by modulating expression specific target genes cellular apoptosis, autophagy, efflux, epithelial-to-mesenchymal transition (EMT), stem cells (CSCs). Moreover, some ncRNAs also possess great as efficient, biomarkers diagnosis prognosis well targets patients. In this review, we summarize recent findings on emerging role underlying mechanisms focus their applications treatment. This information will be benefit early prognostic assessments ncRNA-based strategies
Language: Английский
Citations
79
Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 245, P. 154438 - 154438
Published: April 6, 2023
Language: Английский
Citations
52
Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122946 - 122946
Published: Aug. 8, 2024
Language: Английский
Citations
24
Biological Research, Journal Year: 2025, Volume and Issue: 58(1)
Published: Jan. 27, 2025
Parkinson's disease (PD) is a progressive age-related neurodegenerative whose annual incidence increasing as populations continue to age. Although its pathogenesis has not been fully elucidated, oxidative stress shown play an important role in promoting the occurrence and development of disease. Long noncoding RNAs (lncRNAs), which are more than 200 nucleotides length, also involved PD at transcriptional level via epigenetic regulation, or post-transcriptional by participating physiological processes, including aggregation α-synuclein, mitochondrial dysfunction, stress, calcium stabilization, neuroinflammation. LncRNAs correlated during processes: affects expression multiple lncRNAs, while lncRNAs regulate many genes responses. Oxidative affect other processes associated with neurodegeneration, dysfunction increased neuroinflammation that lead neuronal death. Therefore, modulating levels specific may alleviate pathological damage have neuroprotective effects. This review discusses general mechanisms mechanism underlying PD, teases out through pathogenesis, well identifies possible lncRNAs. Reviewing published studies will help us further understand process identify potential therapeutic strategies for PD.
Language: Английский
Citations
4
Non-Coding RNA, Journal Year: 2021, Volume and Issue: 7(2), P. 36 - 36
Published: June 17, 2021
Development is a complex process regulated both by genetic and epigenetic environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain. Altered lncRNAs has been linked to neurodegenerative, neurodevelopmental mental disorders. The identification characterization that are deregulated or mutated health diseases fundamental understanding transcriptional processes brain function. Crucially, can be exploited novel target for treating neurological In our review, we first summarize recent advances lncRNA functions context cell biology then discussing their association with selected neuronal development
Language: Английский
Citations
98
International Journal of Biological Sciences, Journal Year: 2021, Volume and Issue: 17(12), P. 3188 - 3208
Published: Jan. 1, 2021
Long non-coding RNAs (lncRNAs) are a series of that lack open reading frameworks.Accumulating evidence suggests important roles for lncRNAs in various diseases, including cancers.Recently, lncRNA H19 (H19) became research focus due to its ectopic expression human malignant tumors, where it functioned as an oncogene.Subsequently, was confirmed be involved tumorigenesis and progression many tumors had been implicated promoting cell growth, invasion, migration, epithelial-mesenchymal transition, metastasis, apoptosis.H19 also sequesters some microRNAs, facilitating multilayer molecular regulatory mechanism.In this review, we summarize the abnormal overexpression cancers, which wide prospects further into diagnosis treatment cancers.
Language: Английский
Citations
98
Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9
Published: April 9, 2021
Long non-coding RNAs (lncRNAs) have gained great attention as epigenetic regulators of gene expression in many tissues. Increasing evidence indicates that lncRNAs, together with microRNAs (miRNAs), play a pivotal role osteogenesis. While miRNA action mechanism relies mainly on miRNA-mRNA interaction, resulting suppressed expression, lncRNAs affect mRNA functionality through different activities, including interaction miRNAs. Recent advances RNA sequencing technology improved knowledge into the molecular pathways regulated by and This review reports recent miRNAs roles key osteogenic differentiation. Specifically, we described herein discoveries lncRNA-miRNA crosstalk during differentiation mesenchymal stem cells (MSCs) derived from bone marrow (BM), well other anatomical regions. The deep understanding connection between will strongly improve mechanisms growth development, ultimately leading to discover innovative diagnostic therapeutic tools for disorders diseases.
Language: Английский
Citations
95