Delivery technologies for cancer immunotherapy

Nature Reviews Drug Discovery, Journal Year: 2019, Volume and Issue: 18(3), P. 175 - 196

Published: Jan. 8, 2019

Language: Английский

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The evolution of commercial drug delivery technologies

Nature Biomedical Engineering, Journal Year: 2021, Volume and Issue: 5(9), P. 951 - 967

Published: April 1, 2021

Language: Английский

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Polylactic acid (PLA) controlled delivery carriers for biomedical applications

Advanced Drug Delivery Reviews, Journal Year: 2016, Volume and Issue: 107, P. 163 - 175

Published: July 16, 2016

Language: Английский

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Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

Advanced Drug Delivery Reviews, Journal Year: 2019, Volume and Issue: 143, P. 68 - 96

Published: March 1, 2019

Language: Английский

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Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box

Molecules, Journal Year: 2015, Volume and Issue: 20(9), P. 16852 - 16891

Published: Sept. 16, 2015

The majority of heterocycle compounds and typically common fragments present in most pharmaceuticals currently marketed, alongside with their intrinsic versatility unique physicochemical properties, have poised them as true cornerstones medicinal chemistry. Apart from the already marketed drugs, there are many other being investigated for promising activity against several malignancies. In particular, anticancer research has been capitalizing on dynamic core scaffold these compounds. Nevertheless, any heterocyclic do not come without shortcomings. this review, we provide a concise overview active families main applications medicine. We shall focus those suitable cancer therapy while simultaneously addressing biochemical modes action, biological targets, structure-activity relationships well limitation issues use Finally, considering advent nanotechnology effective selective targeting discuss fundamental aspects considerations nanovectorization such that may improve pharmacokinetic/pharmacodynamic properties heterocycles.

Language: Английский

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The Impact of Nanoparticle Protein Corona on Cytotoxicity, Immunotoxicity and Target Drug Delivery

Nanomedicine, Journal Year: 2015, Volume and Issue: 11(1), P. 81 - 100

Published: Dec. 11, 2015

In a perfect sequence of events, nanoparticles (NPs) are injected into the bloodstream where they circulate until reach target tissue. The ligand on NP surface recognizes its specific receptor expressed tissue and drug is released in controlled manner. However, once physiological environment, NPs interact with biological components surrounded by protein corona (PC). This can trigger an immune response affect toxicity targeting capabilities. this review, we provide survey recent findings NP–PC interactions discuss how PC be used to modulate both cytotoxicity as well improve efficacy targeted delivery nanocarriers.

Language: Английский

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Recent advances of cocktail chemotherapy by combination drug delivery systems

Advanced Drug Delivery Reviews, Journal Year: 2015, Volume and Issue: 98, P. 19 - 34

Published: Nov. 6, 2015

Language: Английский

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Analyte-Responsive Hydrogels: Intelligent Materials for Biosensing and Drug Delivery

Accounts of Chemical Research, Journal Year: 2017, Volume and Issue: 50(2), P. 170 - 178

Published: Feb. 7, 2017

Nature has mastered the art of molecular recognition. For example, using synergistic non-covalent interactions, proteins can distinguish between molecules and bind a partner with incredible affinity specificity. Scientists have developed, continue to develop, techniques investigate better understand As consequence, analyte-responsive hydrogels that mimic these recognitive processes emerged as class intelligent materials. These materials are unique not only in type analyte which they respond but also how recognition is achieved hydrogel responds analyte. Traditional environmental cues such pH, temperature, ionic strength. The functional monomers used make be varied achieve responsive behavior. hydrogels, by incorporating biomolecules inherent properties (e.g., nucleic acids, peptides, enzymes, etc.) into polymer network. Furthermore, addition typical swelling/syneresis responses, exhibit behaviors, gel assembly or disassembly, upon interaction target With diverse tools available for ability generate found great utility wide range applications. In this Account, we discuss strategies making four different classes specifically, non-imprinted, molecularly imprinted, biomolecule-containing, enzymatically hydrogels. Then explore been incorporated sensors drug delivery systems, highlighting examples demonstrate versatility physicochemical changes induced binding exploited detectable signal sensing research area grown, number creative approaches improving selectivity sensitivity (i.e., detection limit) emerged. applications therapeutic release triggered competitive interactions Additionally, including degradable units within network enable sustained release. Several exciting exploiting behavior treatment cancer, diabetes, irritable bowel syndrome discussed detail. We expect combinatorial design will yield potential fields delivery.

Language: Английский

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Cloaking nanoparticles with protein corona shield for targeted drug delivery

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: Oct. 25, 2018

Abstract Targeted drug delivery using nanoparticles can minimize the side effects of conventional pharmaceutical agents and enhance their efficacy. However, translating nanoparticle-based into clinical applications still remains a challenge due to difficulty in regulating interactions on interfaces between biological systems. Here, we present targeting strategy for incorporated with supramolecularly pre-coated recombinant fusion protein which HER2-binding affibody combines glutathione- S -transferase. Once thermodynamically stabilized preferred orientations nanoparticles, adsorbed proteins as corona serum prevent clearance by macrophages, while ensuring systematic functions vitro vivo. This study provides insight use built shield agent through

Language: Английский

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Nanotechnology for COVID-19: Therapeutics and Vaccine Research

ACS Nano, Journal Year: 2020, Volume and Issue: 14(7), P. 7760 - 7782

Published: June 22, 2020

The current global health threat by the novel coronavirus disease 2019 (COVID-19) requires an urgent deployment of advanced therapeutic options available. role nanotechnology is highly relevant to counter this "virus" nano enemy. Nano intervention discussed in terms designing effective nanocarriers conventional limitations antiviral and biological therapeutics. This strategy directs safe delivery available using engineered nanocarriers, blocking initial interactions viral spike glycoprotein with host cell surface receptors, disruption virion construction. Controlling eliminating spread reoccurrence pandemic demands a vaccine strategy. Nanocarriers have potential design risk-free immunization strategies for severe acute respiratory syndrome 2 candidates such as protein constructs nucleic acids. We discuss recent well ongoing nanotechnology-based prophylactic fight against pandemic, outlining key areas nanoscientists step in.

Language: Английский

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