Polymers for Advanced Technologies,
Journal Year:
2022,
Volume and Issue:
34(1), P. 6 - 23
Published: Oct. 4, 2022
Abstract
Electrospinning
procedures
such
as
blend
electrospinning,
coaxial
and
emulsion
electrospinning
have
been
used
for
the
fabrication
of
electrospun
nanofibers
(ENFs)
biomedical
applications.
These
ENFs
are
attracted
great
interest
especially
in
drug
delivery
applications
due
to
their
small
size,
high
surface
area‐to‐volume,
porosity.
The
aim
this
review
is
focus
on
controlled
release
mechanism
among
different
methods,
selectivity
hydrophilic,
water‐soluble
polymers
a
carrier
drug.
depends
mainly
method
loading,
polymeric
interactions,
nature
polymer
swelling,
erosion,
or
degradation.
This
compressed
literature
survey
about
by
factors
affecting
nanofiber
morphologies,
blends
successful
behavior,
involved
steps.
Biomaterials Research,
Journal Year:
2021,
Volume and Issue:
25(1)
Published: Feb. 12, 2021
Various
non-invasive
administrations
have
recently
emerged
as
an
alternative
to
conventional
needle
injections.
A
transdermal
drug
delivery
system
(TDDS)
represents
the
most
attractive
method
among
these
because
of
its
low
rejection
rate,
excellent
ease
administration,
and
superb
convenience
persistence
patients.
TDDS
could
be
applicable
in
not
only
pharmaceuticals
but
also
skin
care
industry,
including
cosmetics.
Because
this
mainly
involves
local
it
can
prevent
buildup
concentration
nonspecific
tissues
targeted
by
drug.
However,
physicochemical
properties
translate
multiple
obstacles
restrictions
delivery,
with
numerous
investigations
conducted
overcome
bottlenecks.
In
review,
we
describe
different
types
available
methods,
along
a
critical
discussion
specific
advantages
disadvantages,
characterization
potential
each
method.
Progress
research
on
methods
has
established
high
efficiency
inherent
TDDS,
which
is
expected
find
applications
wide
range
fields.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Nov. 3, 2023
Abstract
Smart
nanoparticles,
which
can
respond
to
biological
cues
or
be
guided
by
them,
are
emerging
as
a
promising
drug
delivery
platform
for
precise
cancer
treatment.
The
field
of
oncology,
nanotechnology,
and
biomedicine
has
witnessed
rapid
progress,
leading
innovative
developments
in
smart
nanoparticles
safer
more
effective
therapy.
In
this
review,
we
will
highlight
recent
advancements
including
polymeric
dendrimers,
micelles,
liposomes,
protein
cell
membrane
mesoporous
silica
gold
iron
oxide
quantum
dots,
carbon
nanotubes,
black
phosphorus,
MOF
others.
We
focus
on
their
classification,
structures,
synthesis,
intelligent
features.
These
possess
the
ability
various
external
internal
stimuli,
such
enzymes,
pH,
temperature,
optics,
magnetism,
making
them
systems.
Additionally,
review
explore
latest
studies
tumor
targeting
functionalizing
surfaces
with
tumor-specific
ligands
like
antibodies,
peptides,
transferrin,
folic
acid.
also
summarize
different
types
options,
small
molecules,
proteins,
nucleic
acids,
even
living
cells,
potential
use
While
is
promising,
acknowledge
challenges
clinical
prospects
associated
use.
Finally,
propose
blueprint
that
involves
artificial
intelligence-powered
treatment
applications.
By
harnessing
aims
usher
new
era
personalized
therapy,
providing
patients
individualized
options.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(6), P. e17488 - e17488
Published: June 1, 2023
Advances
in
molecular
pharmacology
and
an
improved
understanding
of
the
mechanism
most
diseases
have
created
need
to
specifically
target
cells
involved
initiation
progression
diseases.
This
is
especially
true
for
life-threatening
requiring
therapeutic
agents
which
numerous
side
effects,
thus
accurate
tissue
targeting
minimize
systemic
exposure.
Recent
drug
delivery
systems
(DDS)
are
formulated
using
advanced
technology
accelerate
specific
site,
maximizing
efficacy
minimizing
off-target
accumulation
body.
As
a
result,
they
play
important
role
disease
management
treatment.
DDS
offer
greater
advantages
when
compared
conventional
due
their
enhanced
performance,
automation,
precision,
efficacy.
They
made
nanomaterials
or
miniaturized
devices
with
multifunctional
components
that
biocompatible,
biodegradable,
high
viscoelasticity
extended
circulating
half-life.
review,
therefore,
provides
comprehensive
insight
into
history
technological
advancement
systems.
It
updates
recent
systems,
applications,
challenges
associated
use,
future
directions
performance
use.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(9), P. 5505 - 5616
Published: April 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
Nature Reviews Drug Discovery,
Journal Year:
2023,
Volume and Issue:
22(5), P. 387 - 409
Published: March 27, 2023
Poor
medication
adherence
is
a
pervasive
issue
with
considerable
health
and
socioeconomic
consequences.
Although
the
underlying
reasons
are
generally
understood,
traditional
intervention
strategies
rooted
in
patient-centric
education
empowerment
have
proved
to
be
prohibitively
complex
and/or
ineffective.
Formulating
pharmaceutical
drug
delivery
system
(DDS)
promising
alternative
that
can
directly
mitigate
many
common
impediments
adherence,
including
frequent
dosing,
adverse
effects
delayed
onset
of
action.
Existing
DDSs
already
positively
influenced
patient
acceptability
improved
rates
across
various
disease
types.
The
next
generation
systems
potential
instate
an
even
more
radical
paradigm
shift
by,
for
example,
permitting
oral
biomacromolecules,
allowing
autonomous
dose
regulation
enabling
several
doses
mimicked
single
administration.
Their
success,
however,
contingent
on
their
ability
address
problems
made
unsuccessful
past.
Improving
recognized
as
one
most
impactful
cost-effective
improving
general
population.
Here,
Baryakova
colleagues
assess
next-generation
discuss
impact
had
different
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(44)
Published: Sept. 17, 2021
Abstract
Oral
administration
is
the
most
convenient
and
commonly
used
approach
for
drug
delivery,
while
it
still
a
challenge
to
overcome
complicated
gastrointestinal
barriers
realize
efficient
macromolecular
absorption.
Here,
novel
magneto‐responsive
microneedle
robots
are
presented
oral
delivery
of
versatile
macromolecules.
These
with
three
components
magnetic
substrate,
separable
connection,
tips
generated
by
Lego‐brick‐stacking‐inspired
multistage
3D
fabrication
strategy.
With
assistance
commercial
enteric
capsule
encapsulation,
they
can
be
taken
orally
released
when
entering
small
intestine.
Benefitting
from
their
polarized
orient
intestinal
wall,
barriers,
insert
into
tissue,
deliver
encapsulated
actives
under
specific
fields.
Besides,
after
connection
degrades,
left
inside
tissue
continuous
release,
substrate
excreted
safely.
Based
on
these
features,
practical
values
demonstrated
using
them
insulin
efficiently
regulate
blood
glucose
pigs.
It
believed
that
proposed
diverse
macromolecules
thus
open
new
chapter
administration.
Green Chemistry,
Journal Year:
2022,
Volume and Issue:
24(3), P. 975 - 1020
Published: Jan. 1, 2022
Developing
greener
synthesis
processes
is
an
inescapable
necessity
to
transform
the
industrial
landscape,
mainly
in
pharmaceutical
sector,
into
a
long-term,
sustainable
reality.
Pharmaceutics,
Journal Year:
2021,
Volume and Issue:
13(9), P. 1475 - 1475
Published: Sept. 15, 2021
The
emergence
of
phytosome
nanotechnology
has
a
potential
impact
in
the
field
drug
delivery
and
could
revolutionize
current
state
topical
bioactive
phytochemicals
delivery.
main
challenge
facing
translation
therapeutic
activity
to
clinical
setting
is
extremely
low
absorption
rate
poor
penetration
across
biological
barriers
(i.e.,
skin).
Phytosomes
as
lipid-based
nanocarriers
play
crucial
function
enhancement
pharmacokinetic
pharmacodynamic
properties
herbal-originated
polyphenolic
compounds,
make
this
promising
tool
for
development
new
formulations.
implementation
nanosized
system
enhance
due
their
unique
physiochemical
characteristics,
improving
bioavailability.
In
review,
we
provide
an
outlook
on
knowledge
phytoconstituents
applications.
great
emerging
reviewed,
with
particular
focus
phytosomes
innovative
nanocarrier.
Additionally,
compared
liposomes
gold
standard
phytochemicals.
Finally,
advantages
applications
are
discussed.
