Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems

Cancers, Journal Year: 2019, Volume and Issue: 11(5), P. 640 - 640

Published: May 8, 2019

Targeting nanoparticle (NP) carriers to sites of disease is critical for their successful use as drug delivery systems. Along with optimization physicochemical properties, researchers have focused on surface modification NPs biological ligands. Such ligands can bind specific receptors the target cells. Furthermore, facilitate uptake modified NPs, which referred ‘active targeting’ NPs. In this review, we discuss recent applications including proteins, polysaccharides, aptamers, peptides, and small molecules NP-mediated delivery. We prioritized studies that demonstrated targeting in animals over vitro studies. expect review will assist biomedical working imaging.

Language: Английский

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The regulation of nanomaterials and nanomedicines for clinical application: current and future perspectives

Biomaterials Science, Journal Year: 2020, Volume and Issue: 8(17), P. 4653 - 4664

Published: Jan. 1, 2020

Nanomedicine research has increased drastically over the past ten years, however, before clinical translation many regulatory factors must be considered.

Language: Английский

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Nanomaterials for Nanotheranostics: Tuning Their Properties According to Disease Needs

ACS Nano, Journal Year: 2020, Volume and Issue: 14(3), P. 2585 - 2627

Published: Feb. 7, 2020

Nanotheranostics is one of the biggest scientific breakthroughs in nanomedicine. Most currently available diagnosis and therapies are invasive, time-consuming, associated with severe toxic side effects. Nanotheranostics, on other hand, has potential to bridge this gap by harnessing capabilities nanotechnology nanomaterials for combined therapeutics diagnostics markedly enhanced efficacy. However, nanomaterial applications nanotheranostics still its infancy. This due fact that each disease a particular microenvironment well-defined characteristics, which promotes deeper selection criteria meet needs. In review, we have outlined how designed tailored cancer diseases such as neurodegenerative, autoimmune (particularly rheumatoid arthritis), cardiovascular diseases. The penetrability retention biological system, therapeutic strategy used, imaging mode selected some aspects discussed disease. specific properties terms feasibility, physicochemical challenges, progress clinical trials, toxicity, their future application translational medicine addressed. Our review meticulously critically examines various nanomaterials, including graphene, across several diseases, offering broader perspective emerging field.

Language: Английский

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Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(8)

Published: Feb. 16, 2022

Significance The current application of messenger RNA (mRNA)-based technology has largely been confined to liver diseases because the lack a specific and efficient extrahepatic in vivo systemic mRNA delivery system. Here, we have developed library N-series lipid nanoparticles (LNPs) that could specifically regulate protein composition corona on surface LNPs, which allows lung. We further demonstrated our lung-targeting LNP effectively deliver mouse tuberous sclerosis complex 2 ( Tsc2 ) into TSC2-null cells restore its function, resulting enhanced control tumor burden preclinical model lymphangioleiomyomatosis, destructive lung disease caused by loss-of-function mutations gene.

Language: Английский

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Recent Advances in Understanding the Protein Corona of Nanoparticles and in the Formulation of “Stealthy” Nanomaterials

Frontiers in Bioengineering and Biotechnology, Journal Year: 2020, Volume and Issue: 8

Published: April 3, 2020

In the last decades, staggering progress in nanotechnology brought around a wide and heterogeneous range of nanoparticle-based platforms for diagnosis treatment many diseases. Most these systems are designed to be administered intravenously. This administration route allows nanoparticles (NPs) widely distribute body reach deep organs without invasive techniques. When nanovectors encounter biological environment systemic circulation, dynamic interplay occurs between circulating proteins NPs themselves. The set that bind surface is referred as protein corona (PC). PC has critical role making particles easily recognized by innate immune system, causing their quick clearance phagocytic cells located such lungs, liver, spleen. For same reason defines immunogenicity priming response them and, ultimately, immunological toxicity. Furthermore, can cause physical destabilization agglomeration particles. These problems induced consider only barrier overcome order achieve efficient NPs-based targeting. review will discuss latest advances characterization PC, development stealthy formulations, well manipulation employment an alternative resource prolonging half-life, its use diagnostic applications.

Language: Английский

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Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(13), P. 5365 - 5451

Published: Jan. 1, 2022

The present review details a chronological description of the events that took place during development mesoporous materials, their different synthetic routes and use as drug delivery systems. outstanding textural properties these materials quickly inspired translation to nanoscale dimension leading silica nanoparticles (MSNs). aspects introducing pharmaceutical agents into pores nanocarriers, together with possible biodistribution clearance routes, would be described here. smart nanocarriers are able release high local concentration therapeutic cargo on-demand after application certain stimuli reviewed here, ability deliver precise locations in body. huge progress design MSNs for biomedical applications, including potential treatment diseases, last 20 years will collated required work still needs done achieve clinical materials. This was conceived stand out from past reports since it aims tell story systems by some makers, who could considered among pioneers this area.

Language: Английский

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Protein corona, understanding the nanoparticle–protein interactions and future perspectives: A critical review

International Journal of Biological Macromolecules, Journal Year: 2020, Volume and Issue: 169, P. 290 - 301

Published: Dec. 22, 2020

Language: Английский

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pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics

Communications Biology, Journal Year: 2020, Volume and Issue: 3(1)

Published: March 3, 2020

Abstract The practical application of nanoparticles (NPs) as chemotherapeutic drug delivery systems is often hampered by issues such poor circulation stability and targeting inefficiency. Here, we have utilized a simple approach to prepare biocompatible biodegradable pH-responsive hybrid NPs that overcome these issues. consist drug-loaded polylactic-co-glycolic acid (PLGA) core covalently ‘wrapped’ with crosslinked bovine serum albumin (BSA) shell designed minimize interactions proteins macrophages inhibit target recognition. functionalized the acidity-triggered rational membrane (ATRAM) peptide facilitate internalization specifically into cancer cells within acidic tumor microenvironment. Following uptake, unique intracellular conditions degrade NPs, thereby releasing cargo. showed potent anticancer activity in vitro vivo while exhibiting no toxicity healthy tissue. Our results demonstrate ATRAM-BSA-PLGA are promising targeted platform.

Language: Английский

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Machine learning predicts the functional composition of the protein corona and the cellular recognition of nanoparticles

Proceedings of the National Academy of Sciences, Journal Year: 2020, Volume and Issue: 117(19), P. 10492 - 10499

Published: April 24, 2020

Protein corona formation is critical for the design of ideal and safe nanoparticles (NPs) nanomedicine, biosensing, organ targeting, other applications, but methods to quantitatively predict protein corona, especially functional compositions, remain unavailable. The traditional linear regression model performs poorly as measured by R 2 (less than 0.40). Here, performance with over 0.75 in prediction was achieved integrating a machine learning meta-analysis. NPs without modification surface were identified two most important factors determining formation. According experimental verification, compositions (e.g., immune proteins, complement apolipoproteins) complex coronas precisely predicted good (most 0.80). Moreover, method successfully cellular recognition uptake macrophages cytokine release) mediated proteins. This workflow provides accurately composition that determines nanotoxicity guide synthesis applications wide range overcoming limitations uncertainty.

Language: Английский

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Tailoring the component of protein corona via simple chemistry

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Oct. 4, 2019

Abstract Control over the protein corona of nanomaterials allows them to function better. Here, by taking graphene/gold as examples, we comprehensively assessed association surface properties with corona. As revealed in vitro measurements and computations, interaction between HSA/IgE was inversely correlated hydroxyl group availability, whereas that ApoE comparatively less relevant. Molecular simulations number distribution groups could regulate manner which interact proteins. Moreover, validated pre-adsorption before injection enhances blood circulation relative their pristine IgE-coated counterparts. This benefit can be attributed invulnerability complementary system provided ApoE, whose encasement does not increase cytotoxicity. Overall, this study offers a robust yet simple way create enriched dysopsonins realize better delivery efficacy.

Language: Английский

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