Soybean Antigen Protein-Induced Intestinal Barrier Damage by Trigging Endoplasmic Reticulum Stress and Disordering Gut Microbiota in Weaned Piglets DOI Creative Commons
Lei Wang, Y. Liu, Daoliang Zhang

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(18), P. 6500 - 6500

Published: Sept. 7, 2023

Endoplasmic reticulum (ER) stress is a crucial factor in the pathogenesis of intestinal diseases. Soybean antigenic proteins (β-conglycinin and soy glycinin) induce hypersensitivity reactions barrier damage. However, whether this damage associated with ER stress, autophagy, gut microbiome largely unclear. Therefore, study, we aimed to investigate effect dietary supplementation glycinin (11S β-conglycinin (7S on flora weaned piglets. Thirty healthy 21-day-old “Duroc × Long White Yorkshire” piglets were randomly divided into three groups fed basic, 7S-supplemented, or 11S-supplemented diet for one week. The results indicated that 7S/11S disrupted growth performance, damaged integrity, impaired goblet cell function (p < 0.05). Moreover, induced blocked autophagic flux jejunum 0.05) increased relative abundance pathogenic 0.01) decreased beneficial In conclusion, induces blockage, microbiota imbalance,

Language: Английский

The impact of the gut microbiome on extra-intestinal autoimmune diseases DOI
Eiji Miyauchi, Chikako Shimokawa, Alex Steimle

et al.

Nature reviews. Immunology, Journal Year: 2022, Volume and Issue: 23(1), P. 9 - 23

Published: May 9, 2022

Language: Английский

Citations

236
Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper DOI Open Access
Marek Jutel, Ioana Agache, Magdalena Zemelka‐Wiącek

et al.

Allergy, Journal Year: 2023, Volume and Issue: 78(11), P. 2851 - 2874

Published: Oct. 10, 2023

Abstract The exponential growth of precision diagnostic tools, including omic technologies, molecular diagnostics, sophisticated genetic and epigenetic editing, imaging nano‐technologies patient access to extensive health care, has resulted in vast amounts unbiased data enabling in‐depth disease characterization. New endotypes have been identified for various allergic diseases triggered the gradual transition from a description focused on symptoms identifying biomarkers intricate pathogenetic metabolic pathways. Consequently, current taxonomy be revised better categorization. This European Academy Allergy Clinical Immunology Position Paper responds this challenge provides modern nomenclature diseases, which respects earlier classifications back early 20th century. Hypersensitivity reactions originally described by Gell Coombs extended into nine different types comprising antibody‐ (I‐III), cell‐mediated (IVa‐c), tissue‐driven mechanisms (V‐VI) direct response chemicals (VII). Types I‐III are linked classical newly clinical conditions. Type IVa‐c specified detailed according understanding T1, T2 T3 responses. V‐VI involve epithelial barrier defects metabolic‐induced immune dysregulation, while cellular inflammatory responses covered type VII. It is notable that several combinations mixed may appear setting. relevance approach allergy practice will conferred another article follow year, aiming at showing where can overlap evolve over lifetime.

Language: Английский

Citations

118
Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice DOI Creative Commons
Amy Parrish, Marie Boudaud, Erica T. Grant

et al.

Nature Microbiology, Journal Year: 2023, Volume and Issue: 8(10), P. 1863 - 1879

Published: Sept. 11, 2023

Abstract Alterations in the gut microbiome, including diet-driven changes, are linked to rising prevalence of food allergy. However, little is known about how specific bacteria trigger breakdown oral tolerance. Here we show that depriving specific-pathogen-free mice dietary fibre leads a microbiota signature with increases mucin-degrading bacterium Akkermansia muciniphila . This associated intestinal barrier dysfunction, increased expression type 1 and 2 cytokines IgE-coated commensals colon, which result an exacerbated allergic reaction allergens, ovalbumin peanut. To demonstrate causal role A. , employed tractable synthetic human gnotobiotic mice. The presence within microbiota, combined deprivation, resulted stronger anti-commensal IgE coating innate type-2 immune responses, worsened symptoms Our study provides important insights into microbes can regulate pathways allergy diet-dependent manner.

Language: Английский

Citations

49
Diet-driven differential response of Akkermansia muciniphila modulates pathogen susceptibility DOI

Mathis Wolter,

Erica T. Grant, Marie Boudaud

et al.

Molecular Systems Biology, Journal Year: 2024, Volume and Issue: 20(6), P. 596 - 625

Published: May 14, 2024

Language: Английский

Citations

23
Carotenoids and Their Health Benefits as Derived via Their Interactions with Gut Microbiota DOI Creative Commons
Abdulkerim Eroglu, Ibrahim S. Al’Abri, Rachel E. Kopec

et al.

Advances in Nutrition, Journal Year: 2022, Volume and Issue: 14(2), P. 238 - 255

Published: Dec. 16, 2022

Carotenoids have been related to a number of health benefits. Their dietary intake and circulating levels associated with reduced incidence obesity, diabetes, certain types cancer, even lower total mortality. potential interaction the gut microbiota (GM) has generally overlooked but may be relevance, as carotenoids largely bypass absorption in small intestine are passed on colon, where they appear part degraded into unknown metabolites. These include apo-carotenoids that biological effects because higher aqueous solubility electrophilicity could better target transcription factors, i.e., NF-κB, PPARγ, RAR/RXRs. If absorbed both local systemic effects. Certain microbes supplemented were also reported produce colon. Although some bactericidal aspects shown vitro, few studies demonstrated prebiotic-like effect, resulting bacterial shifts health-associated properties. Also, stimulation IgA play role this respect. further contribute mucosal barrier health, such stabilizing tight junctions. This review highlights gut-related health-beneficial emphasizes current research gaps regarding carotenoid-GM interactions.

Language: Английский

Citations

60
Human milk oligosaccharides: potential therapeutic aids for allergic diseases DOI Open Access

Isabel Tarrant,

B. Brett Finlay

Trends in Immunology, Journal Year: 2023, Volume and Issue: 44(8), P. 644 - 661

Published: July 11, 2023

Language: Английский

Citations

25
Recent progress on engineered micro/nanomaterials mediated modulation of gut microbiota for treating inflammatory bowel disease DOI

Lingling Kan,

Ziwen Zheng,

Wanyue Fu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 43 - 65

Published: April 17, 2024

Language: Английский

Citations

16
Regulatory mechanisms of the probiotic-targeted gut–liver axis for the alleviation of alcohol-related liver disease: a review DOI

Feiyu Yang,

Xiangfei Li, Jing Sun

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: Feb. 5, 2025

Alcohol abuse-triggered alcohol-related liver disease (ALD) has become as a global public health concern that substantially affects the well-being and clinical status of patients. Although modern medicine provides various treatments for ALD, their effectiveness is limited can lead to adverse side effects. Probiotics have been employed prevent, alleviate, even treat with promising results. However, few comprehensive reviews are available on how they mitigate ALD by targeting gut-liver axis. This review systematically clarifies specific mediators axis in healthy states. It also describes alterations observed ALD. Furthermore, this thoroughly summarizes underlying mechanisms through which probiotics act relieve discusses current challenges faced research applications. Finally, we discuss future prospects using improves our understanding supports development application target therapeutic use.

Language: Английский

Citations

1
Immune responses in the irritable bowel syndromes: time to consider the small intestine DOI Creative Commons
Grace L. Burns, Nicholas J. Talley, Simon Keely

et al.

BMC Medicine, Journal Year: 2022, Volume and Issue: 20(1)

Published: March 31, 2022

Abstract Background Irritable bowel syndrome (IBS) is considered a disorder of gut-brain interaction (DGBI), presenting as chronic abdominal pain and altered defaecation. Symptoms are often food related. Much work in the field has focused on identifying physiological, immune microbial abnormalities colon patients; however, evidence small intestinal activation imbalance been reported studies. The significance such findings largely underappreciated despite growing body implicating homeostatic pathogenesis DGBIs. Main text Small mechanosensation characteristic feature IBS. Furthermore, barrier functions have demonstrated IBS patients with diarrhoea-predominant subtype. bacterial overgrowth increased populations mast cells frequently associated IBS, low-grade inflammation reports localised hypersensitivity responses implicate intestine site immune-microbial-food interactions. Conclusions Given association symptoms intake large proportion emerging these patients, current literature suggests not limited to but rather may involve dysfunction entire tract. It remains unclear if regional variation pathology explains various symptom phenotypes further should consider tract whole answer this question.

Language: Английский

Citations

31
Interaction of Pyrogallol-Containing Polyphenols with Mucin Reinforces Intestinal Mucus Barrier Properties DOI

Guangxin Feng,

Kaining Han,

Qian Yang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2022, Volume and Issue: 70(30), P. 9536 - 9546

Published: July 19, 2022

High consumption of polyphenol-rich green tea, coffee, fruits, and vegetables is associated with a low risk human chronic diseases. Recent studies highlight the relevance polyphenol-mediated gut microbiota modulation its impact on mucus barrier. Herein, we study direct interaction epicatechin (EC), epigallocatechin gallate (EGCG), tannic acid (TA) intestinal mucin by isothermal titration calorimetry multiple particle tracking barrier using ex vivo Caco-2/HT29-MTX cocultures. Results show that pyrogallol-containing polyphenols EGCG TA exhibit strong binding to reinforce barrier, whereas EC does not. ECGG also mitigate gliadin-mediated cytotoxicity inflammation. The chemical nucleophilic thiol groups mucins shows their roles as cross-linkers networks. These results bring novel understanding health benefits provide support for beverages like tea potential dietary therapy gluten-related disorders.

Language: Английский

Citations

26