Science China Materials, Journal Year: 2024, Volume and Issue: 67(9), P. 2749 - 2766
Published: July 2, 2024
Language: Английский
American Journal of Neuroradiology, Journal Year: 2025, Volume and Issue: 46(4), P. 646 - 647
Published: April 1, 2025
Language: Английский
Citations
0
Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Language: Английский
Citations
0
Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(2), P. 10 - 10
Published: April 9, 2025
Nanotheranostics—where nanoscale materials serve both diagnostic and therapeutic functions—are rapidly transforming gene therapy by tackling critical delivery challenges. This review explores the design engineering of various nanoparticle systems (lipid-based, polymeric, inorganic, hybrid) to enhance stability, targeting, endosomal escape genetic payloads. We discuss how real-time imaging capabilities integrated into these platforms enable precise localization controlled release genes, improving treatment efficacy while reducing off-target effects. Key strategies overcome barriers (such as proton sponge effect photothermal disruption) achieve nuclear are highlighted, along with recent advances in stimuli-responsive that facilitate spatiotemporal control expression. Clinical trials preclinical studies demonstrate expanding role nanotheranostics managing cancer, inherited disorders, cardiovascular neurological diseases. further address regulatory manufacturing hurdles must be for widespread clinical adoption nanoparticle-based therapies. By synthesizing progress ongoing challenges, this underscores transformative potential effective, targeted, image-guided delivery.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143515 - 143515
Published: April 1, 2025
Language: Английский
Citations
0
Magnetic Resonance Imaging Clinics of North America, Journal Year: 2024, Volume and Issue: 32(4), P. 681 - 698
Published: July 26, 2024
Language: Английский
Citations
3
Science Bulletin, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12485 - 12485
Published: Nov. 21, 2024
This review explores recent advancements in gene therapy as a potential treatment for neurodegenerative diseases, focusing on intervention mechanisms, administration routes, and associated limitations. Following the PRISMA procedure guidelines, we systematically analyzed studies published since 2020 using PICO framework to derive reliable conclusions. The efficacy of various therapies was evaluated Parkinson's disease (n = 12), spinal muscular atrophy 8), Huntington's 3), Alzheimer's amyotrophic lateral sclerosis 6). For each condition, assessed therapeutic approach, curative or disease-modifying potential, delivery methods, advantages, drawbacks, side effects. Results indicate that targeting specific genes are particularly effective monogenic disorders, with promising clinical outcomes expected near future. In contrast, polygenic primarily aim promote cell survival. A major challenge remains: translation animal model success human application. Additionally, while intracerebral methods enhance efficacy, they highly invasive. Despite these hurdles, represents frontier underscoring need continued research refine personalize treatments condition.
Language: Английский
Citations
2
ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 22752 - 22779
Published: Aug. 12, 2024
Recent years have witnessed rapid progress in the discovery of therapeutic proteins and peptides for treatment central nervous system (CNS) diseases. However, their clinical applications been considerably hindered by challenges such as low biomembrane permeability, poor stability, short circulation time, formidable blood–brain barrier (BBB). Recently, substantial improvements made understanding dynamics BBB developing efficient approaches delivering to CNS, especially using various nanoparticles. Herein, we present an overview up-to-date under physiological pathological conditions, emphasizing effects on brain drug delivery. We summarize advanced strategies elucidate underlying mechanisms brain. highlight developments nanocarriers treating CNS diseases via crossing. also provide critical opinions limitations obstacles current put forward prospects future research.
Language: Английский
Citations
1
Extracellular Vesicle, Journal Year: 2024, Volume and Issue: 4, P. 100057 - 100057
Published: Nov. 26, 2024
Language: Английский
Citations
1
Science China Materials, Journal Year: 2024, Volume and Issue: 67(9), P. 2749 - 2766
Published: July 2, 2024
Language: Английский
Citations
0