Tropical Animal Health and Production, Journal Year: 2025, Volume and Issue: 57(3)
Published: March 31, 2025
Language: Английский
Molecular Metabolism, Journal Year: 2022, Volume and Issue: 66, P. 101633 - 101633
Published: Nov. 7, 2022
Obesity and its associated comorbidities represent a global health challenge with need for well-tolerated, effective, mechanistically diverse pharmaceutical interventions. Oxyntomodulin is gut peptide that activates the glucagon receptor (GCGR) glucagon-like peptide-1 (GLP-1R) reduces bodyweight by increasing energy expenditure reducing intake in humans. Here we describe pharmacological profile of novel (GCGR)/GLP-1 dual agonist BI 456906.BI 456906 was characterized using cell-based vitro assays to determine functional agonism. In vivo studies were performed acute subchronic dosing regimens demonstrate target engagement GCGR GLP-1R, weight lowering efficacy.BI potent, acylated containing C18 fatty acid as half-life extending principle support once-weekly Pharmacological doses provided greater reductions mice compared maximally effective GLP-1R semaglutide. 456906's superior efficacy consequence increased reduced food intake. Engagement both receptors demonstrated via glucose tolerance, intake, gastric emptying tests liver nicotinamide N-methyltransferase mRNA expression circulating biomarkers (amino acids, fibroblast growth factor-21) GCGR. The activity at supported knockout transgenic reporter mice, an ex bioactivity assay.BI potent GCGR/GLP-1R robust anti-obesity achieved decreasing
Language: Английский
Citations
84
Global Challenges, Journal Year: 2023, Volume and Issue: 7(5)
Published: April 25, 2023
Dietary proteins derived from animal sources, although containing well-balanced profiles of essential amino acids, have considerable environmental and adverse health effects associated with the intake some protein-based products. Consuming foods based on carries a higher risk developing non-communicable diseases such as cancer, heart disease, non-alcoholic fatty liver disease (NAFLD), inflammatory bowel (IBD). Moreover, dietary protein consumption is increasing due to population growth, posing supply challenge. There is, therefore, growing interest in discovering novel alternative sources. In this context, microalgae been recognized strategic crops that can provide sustainable source protein. Compared conventional high-protein crops, using microalgal biomass for production presents several advantages food feed terms productivity, sustainability, nutritional value. positively impact environment by not exploiting land or causing water pollution. Many studies revealed potential an added value positive human their anti-inflammatory, antioxidant, anti-cancer properties. The main emphasis review health-promoting applications microalgae-based proteins, peptides, bioactive substances IBD NAFLD.
Language: Английский
Citations
49
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2251 - 2251
Published: Feb. 13, 2024
This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy associated diseases/disorders, or just related rather independent pathologies. The human nature MS (its exceptionality in Nature and its close interdependence with action evolution) is presented discussed. text also describes components, special emphasis description their interrelations (including syndromic development recruitment), as well consequences upon energy handling partition. main theories MS’s origin are relation to hepatic steatosis, type 2 diabetes, obesity, encompass most components described so far. differential effects sex biological considered under light social needs evolution, which directly epidemiology, severity, relations senescence. triggering maintenance factors discussed, especial inflammation, complex process affecting different levels organization critical element for development. Inflammation operation connective tissue adipose organ) widely studied acknowledged influence diet. role diet composition, including transcendence anaplerotic Krebs cycle from dietary amino acid supply (and timing), developed context testosterone β-estradiol control insulin-glycaemia core system carbohydrate-triacylglycerol handling. high probability acting unique (essentially monophyletic) presented, together additional perspectives/considerations treatment this ‘very’ disease.
Language: Английский
Citations
30
Nutrients, Journal Year: 2022, Volume and Issue: 14(19), P. 3887 - 3887
Published: Sept. 20, 2022
This study conducted a comparative analysis of the amino acid compositions Chinese Huangnuo 9 fresh sweet–waxy corn from three different provinces in China—Inner Mongolia, Jilin, and Heilongjiang Province. Moreover, we established nutritive evaluation system based on profiles to evaluate, compare, rank planted regions. A total 17 acids were quantified, composition was analyzed evaluated. The quality determined by pattern spectrum, chemical evaluations (including CS, AAS, EAAI, BV, U(a,u), NI, F, predict PER, PDCAAS), flavor evaluation, matching degree results factor analysis. showed that protein content 1–1 Inner Mongolia highest (40.26 ± 0.35 mg/g), but results, digestion, absorption efficiency 1–2 best. profile closest each evaluation’s model spectrum. diversity 3–2 best, 3–3 had most essential content. divided into principal component analyses: functional components (Leu, Pro, Glu, His, Ile, Ser, Met, Val, Tyr, Thr), regulatory (Lys, Gly, Ala, Asp, Arg, Trp), protection (Phe). scores comprehensive score all highest, followed 1–1. nutritional values 12 samples.
Language: Английский
Citations
45
Annual Review of Microbiology, Journal Year: 2023, Volume and Issue: 77(1), P. 479 - 497
Published: June 20, 2023
Amino acids are indispensable substrates for protein synthesis in all organisms and incorporated into diverse aspects of metabolic physiology signaling. However, animals lack the ability to synthesize several them must acquire these essential amino from their diet or perhaps associated microbial communities. The therefore occupy a unique position health relationships with microbes. Here we review recent work connecting production metabolism host biology, reciprocal impacts on We focus roles branched-chain (valine, leucine, isoleucine) tryptophan host-microbe communication intestine humans other vertebrates. then conclude by highlighting research questions surrounding less-understood acid animal hosts.
Language: Английский
Citations
28
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2024, Volume and Issue: 157, P. 106646 - 106646
Published: Sept. 1, 2024
Language: Английский
Citations
13
LWT, Journal Year: 2024, Volume and Issue: 192, P. 115723 - 115723
Published: Jan. 1, 2024
Russula vinosa Lindbl (RVL) is a multifunctional edible fungus that has recently gained widespread attention due to its numerous nutritious, delicious, and medicinal properties. However, little been directed toward analyzing comprehensive phytochemical profiling bioactivity in RVL. This study aimed evaluate the of RVL systematically. Herein, we characterized global using LC/GC-MS-based multiomics strategy through initial methodological optimization. A total 633 metabolites were identified untargeted multiomics, with fatty acids, amino polyphenols, terpenoids, organic sugars, phospholipids as primary metabolites. Polyphenols served main active components by quantitative analysis antioxidant evaluation, impling they may be related antitumor effects. Moreover, based on profiling, potential gene targets mechanisms anticancer properties explored network pharmacology. The significance this lies expanding our understanding bioactive providing references for further utilization exploitation. Therefore, could an excellent raw material food, nutraceutical, pharmaceutical industries richness nutrients ingredients.
Language: Английский
Citations
9
The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: 126, P. 109581 - 109581
Published: Jan. 13, 2024
Language: Английский
Citations
9
Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 201 - 201
Published: March 13, 2025
Background: Tumor cells engage in continuous self-replication by utilizing a large number of resources and capabilities, typically within an aberrant metabolic regulatory network to meet their own demands. This dysregulation leads the formation tumor microenvironment (TME) most solid tumors. Nanomedicines, due unique physicochemical properties, can achieve passive targeting certain tumors through enhanced permeability retention (EPR) effect, or active deliberate design optimization, resulting accumulation TME. The use nanomedicines target critical pathways holds significant promise. However, requires careful selection relevant drugs materials, taking into account multiple factors. traditional trial-and-error process is relatively inefficient. Artificial intelligence (AI) integrate big data evaluate delivery efficiency nanomedicines, thereby assisting nanodrugs. Methods: We have conducted detailed review key papers from databases, such as ScienceDirect, Scopus, Wiley, Web Science, PubMed, focusing on reprogramming, mechanisms action development metabolism, application AI empowering nanomedicines. integrated content present current status research metabolism potential future directions this field. Results: Nanomedicines possess excellent TME which be utilized disrupt cells, including glycolysis, lipid amino acid nucleotide metabolism. disruption selective killing disturbance Extensive has demonstrated that AI-driven methodologies revolutionized nanomedicine development, while concurrently enabling precise identification molecular regulators involved oncogenic reprogramming pathways, catalyzing transformative innovations targeted cancer therapeutics. Conclusions: great Additionally, will accelerate discovery metabolism-related targets, empower optimization help minimize toxicity, providing new paradigm for development.
Language: Английский
Citations
2
Open Agriculture, Journal Year: 2025, Volume and Issue: 10(1)
Published: Jan. 1, 2025
Abstract Global agriculture feeds over seven billion people and alarmingly, this number is expected to increase by a further 50% 2050. To meet the additional food demand, world development report has estimated that crop production should 70–100% However, climate change, expanding soil salinization, developing shortages of freshwater have negatively affected edible plants around world. Current attempts adapt these conditions include use salt-tolerant plant species with potential economic value fulfil increasing demand escalated human population. The wild halophyte Tetragonia decumbens commonly known as dune spinach be used leafy vegetable, source dietary salt, in phytoremediation secondary metabolites. it remains underutilized South Africa commercial farming never been explored. This review examined domesticating describing its morphology ecology, propagation cultivation requirements well on health saline soils. Furthermore, analysis useful towards research popularization underexploited halophyte.
Language: Английский
Citations
1