Better Together: Interorganellar Communication in the Regulation of Proteostasis DOI Creative Commons
Andreas Köhler, Verena Kohler

Contact, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

An extensive network of chaperones and folding factors is responsible for maintaining a functional proteome, which the basis cellular life. The underlying proteostatic mechanisms are not isolated within organelles, rather they connected over organellar borders via signalling processes or direct association contact sites. This review aims to provide conceptual understanding across organelle borders, focussing on individual organelles. discussion highlights precision these finely tuned systems, emphasising complicated balance between protection adaptation stress. In this review, we discuss widely accepted aspects while shedding light newly discovered perspectives.

Language: Английский

Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases DOI Creative Commons
Carolina Ferreira, Pedro Vieira, Susana Machado

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 15, 2024

Mounting evidence progressively appreciates the vital interplay between immunity and metabolism in a wide array of immunometabolic chronic disorders, both autoimmune non-autoimmune mediated. The immune system regulates functioning cellular within organs like brain, pancreas and/or adipose tissue by sensing adapting to fluctuations microenvironment’s nutrients, thereby reshaping metabolic pathways that greatly impact pro- or anti-inflammatory immunophenotype. While it is agreed relies on an adequate nutritional status function properly, we are only just starting understand how supply single combined all them termed immunonutrients, can steer cells towards less inflamed, tolerogenic Polyphenols, class secondary metabolites abundant Mediterranean foods, pharmacologically active natural products with outstanding immunomodulatory actions. Upon binding range receptors highly expressed (e.g. AhR, RAR, RLR), they act through mitochondria-centered multi-modal approach. First , polyphenols activate nutrient via stress-response pathways, essential for responses. Second regulate mammalian target rapamycin (mTOR)/AMP-activated protein kinase (AMPK) balance well-tolerated caloric restriction mimetics. Third interfere assembly NLR family pyrin domain containing 3 (NLRP3) endoplasmic reticulum-mitochondria contact sites, inhibiting its activation while improving mitochondrial biogenesis autophagosome-lysosome fusion. Finally chromatin remodeling coordinates epigenetic reprogramming. This work moves beyond well-documented antioxidant properties polyphenols, offering new insights into multifaceted nature these compounds. It proposes mechanistical appraisal regulatory which modulate response, alleviating low-grade inflammation. Furthermore, draws parallels pharmacological interventions polyphenol-based immunonutrition their modes immunomodulation across spectrum socioeconomically impactful diseases such as Multiple Sclerosis, Diabetes (type 1 2) even Alzheimer’s disease. Lastly, discusses existing challenges thwart translation polyphenols-based immunonutritional long-term clinical studies. Overcoming limitations will undoubtedly pave way precision nutrition protocols provide personalized guidance tailored plans.

Language: Английский

Citations

23
The NLRP3 inflammasome: regulation by metabolic signals DOI Creative Commons

Antoni Olona,

Stuart Leishman, Paras Anand

et al.

Trends in Immunology, Journal Year: 2022, Volume and Issue: 43(12), P. 978 - 989

Published: Nov. 9, 2022

Language: Английский

Citations

65
Best practice for wound repair and regeneration use of cellular, acellular and matrix-like products (CAMPs) DOI
Stephanie Wu, Marissa J. Carter,

Windy Cole

et al.

Journal of Wound Care, Journal Year: 2023, Volume and Issue: 32(Sup4b), P. S1 - S31

Published: April 1, 2023

There are currently over 80 biomaterials derived from autologous, allogeneic, synthetic and xenogeneic sources, or a combination of any all these types materials, available for soft-tissue coverage to effect wound closure. Often generically referred as cellular and/or tissue-based products (CTPs), they manufactured under various trade names marketed variety indications.

Language: Английский

Citations

25
MCSdb, a database of proteins residing in membrane contact sites DOI Creative Commons

Xianrun Pan,

Liping Ren, Yu Yang

et al.

Scientific Data, Journal Year: 2024, Volume and Issue: 11(1)

Published: March 8, 2024

Abstract Organelles do not act as autonomous discrete units but rather interconnected hubs that engage in extensive communication by forming close contacts called “membrane contact sites (MCSs)”. And many proteins have been identified residing MCS and playing important roles maintaining fulfilling specific functions within these microdomains. However, a comprehensive compilation of is still lacking. Therefore, we developed MCSdb, manually curated resource complexes from publications. MCSdb documents 7010 protein entries 263 complexes, involving 24 organelles 44 MCSs across 11 species. Additionally, orchestrates all data into different categories with multitudinous information for presenting proteins. In summary, provides valuable accelerating functional interpretation interorganelle deciphering.

Language: Английский

Citations

11
Mechanisms and therapeutic prospect of the JAK-STAT signaling pathway in liver cancer DOI

Junjun Jia,

Xuelian Zhou,

Qingfei Chu

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 480(1), P. 1 - 17

Published: March 22, 2024

Language: Английский

Citations

11
Functional multi-organelle units control inflammatory lipid metabolism of macrophages DOI Creative Commons
Julia A Zimmermann,

Kerstin Lucht,

Manuel Stecher

et al.

Nature Cell Biology, Journal Year: 2024, Volume and Issue: 26(8), P. 1261 - 1273

Published: July 5, 2024

Eukaryotic cells contain several membrane-separated organelles to compartmentalize distinct metabolic reactions. However, it has remained unclear how these organelle systems are coordinated when adapt pathways support their development, survival or effector functions. Here we present OrgaPlexing, a multi-spectral imaging approach for the comprehensive mapping of six key and interactions. We use this analysis on macrophages, immune that undergo rapid switches upon sensing bacterial inflammatory stimuli. Our results identify lipid droplets (LDs) as primary responder organelle, which forms three- four-way interactions with other organelles. While clusters endoplasmic reticulum (ER) mitochondria (mitochondria-ER-LD unit) help supply fatty acids LD growth, additional recruitment peroxisomes (mitochondria-ER-peroxisome-LD supports acid efflux from LDs. Interference individual components units direct functional consequences mediator synthesis. Together, show macrophages form multi-organellar adaptation provide an experimental strategy organelle-metabolic signalling hubs.

Language: Английский

Citations

11
Inter-organelle communication dynamically orchestrates juvenile hormone biosynthesis and female reproduction DOI Creative Commons
Shiming Zhu, Fangfang Liu, Xiaoyi Chen

et al.

National Science Review, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Inter-organelle communication coordinates cellular homeostasis and function. Juvenile hormone (JH) is produced in the corpora allata (CA) acts as a gonadotrophic most insects. Using transcriptomic, biochemical, molecular, genetic analyses, here we investigated underlying mechanism of how inter-organelle dynamically orchestrates JH biosynthesis female reproduction American cockroach, Periplaneta americana. The extracellular stimuli insulin allatostatin act through their membrane receptors antagonistically regulate RyR-mediated Ca2+ release from endoplasmic reticulum CA cells. Ca2+-activated CaMKII stimulates energy metabolism mitochondria partially via SLC25A6, induces expression biosynthetic genes HMGR, Jhamt, Cyp15a1 activating transcription factor CREB, which recruits CBP for histone acetylation nucleus. Additionally, interact with CREB-CBP mitonuclear to biosynthesis. From perspective communication, this comprehensive study significantly advanced our understanding reproductive biology

Language: Английский

Citations

1
Blocking Spatiotemporal Crosstalk between Subcellular Organelles for Enhancing Anticancer Therapy with Nanointercepters DOI
Huiyan Li, Huilin Zhang, Xiaofang He

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(18)

Published: Feb. 6, 2023

The spatiotemporal characterization of signaling crosstalk between subcellular organelles is crucial for the therapeutic effect malignant tumors. Blocking interactive in this fashion significant but challenging. Herein, a communication interception strategy reported, which blocks cancer therapy with underlying molecular mechanisms. Briefly, amorphous-core@crystalline-shell Fe@Fe3 O4 nanoparticles (ACFeNPs) are fabricated to specifically block lysosomes and endoplasmic reticulum (ER) by hydroxyl radicals generated along their trajectory through heterogeneous Fenton reaction. ACFeNPs initially enter trigger autophagy, then continuous lysosomal damage generation functional autolysosomes, mediates ER-lysosome crosstalk, thus autophagy paralyzed. Thereafter, released from induce ER stress. Without alleviation ER-stress-associated apoptotic pathway fully activated, resulting remarkable effect. This provides wide venue nanomedicine exert biological advantages confers new perspective design novel anticancer drugs.

Language: Английский

Citations

19
Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity DOI Creative Commons
Güneş Parlakgül, Song Pang, Leonardo Luís Artico

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 10, 2024

The hepatocytes within the liver present an immense capacity to adapt changes in nutrient availability. Here, by using high resolution volume electron microscopy, we map how hepatic subcellular spatial organization is regulated during nutritional fluctuations and as a function of zonation. We identify that fasting leads remodeling endoplasmic reticulum (ER) architecture hepatocytes, characterized induction single rough ER sheet around mitochondria, which becomes larger flatter. These alterations are enriched periportal mid-lobular but not pericentral hepatocytes. Gain- loss-of-function vivo models demonstrate Ribosome receptor binding protein1 (RRBP1) required enable fasting-induced sheet-mitochondria interactions regulate fatty acid oxidation. Endogenous RRBP1 regions liver. In obesity, ER-mitochondria distinct fails induce sheet-mitochondrion interactions. findings illustrate importance molecular for hepatocyte metabolic flexibility.

Language: Английский

Citations

7
The Sentient Cell DOI
Arthur S. Reber, František Baluška, William B. Miller

et al.

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 5, 2023

Abstract This volume is the natural follow-up to Arthur Reber’s 2019 book, The First Minds: Caterpillars, ‘Karyotes, and Consciousness (TFM). In that earlier work, Cellular Basis of (CBC) theory was developed based on a number efforts published in variety journals between 1997 as well talks, colloquia, presentations at conferences. core proposition TFM life mind are co-terminous. All organisms, all species extant extinct, sentient. have an existentially secure consciousness—without which they would been evolutionary dead-ends, unable survive chaotic, dangerous environment first appeared. And, importantly, forms sentience, cognitive functioning right up including those expressed by humans, evolved from original expression consciousness birth prokaryotes. unicellular widely accepted, foundational principle biological social sciences. CBC simply applies same sentience.

Language: Английский

Citations

13