Long-term outcomes of patients with a pre-existing neurological condition after SARS-CoV-2 infection

Journal of the Neurological Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123477 - 123477

Published: April 1, 2025

Language: Английский

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A Comprehensive Review of the Global Epidemiology, Clinical Management, Socio-Economic Impacts, and National Responses to Long COVID with Future Research Directions

Diagnostics, Journal Year: 2024, Volume and Issue: 14(11), P. 1168 - 1168

Published: May 31, 2024

Long COVID, characterized by a persistent symptom spectrum following SARS-CoV-2 infection, poses significant health, social, and economic challenges. This review aims to consolidate knowledge on its epidemiology, clinical features, underlying mechanisms guide global responses;

Language: Английский

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A Comprehensive Global Review of Epidemiology, Clinical Management, Socio-Economic Impacts and National Responses of Long COVID with Future Research Directions

Published: April 26, 2024

Background: Long COVID, characterized by a persistent symptom spectrum following SARS-CoV-2 infection, poses significant health, social, and economic challenges. This review aims to consolidate knowledge on its epidemiology, clinical features, underlying mechanisms guide global responses; Methods: We conducted systematic literature review, analyzing peer-reviewed articles reports gather comprehensive data long COVID’s symptomatology, management approaches; Results: Our analysis revealed wide array of COVID symptoms risk factors, with notable demographic variability. The current understanding pathophysiology suggests multifactorial origin yet remains partially understood. Emerging diagnostic criteria potential therapeutic strategies were identified, highlighting advancements in management.; Conclusion: highlights the multifaceted nature revealing broad symptoms, diverse complex interplay physiological underpinning condition. disorders will continue weigh healthcare systems years come. Ad-dressing requires holistic strategy that integrates care, social support, policy initiatives. findings underscore need for increased international cooperation research health planning address challenges COVID. There is call continued refinement treatment modalities, emphasizing multidisciplinary approach manage ongoing evolving impacts

Language: Английский

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Long-term outcomes of patients with Parkinson’s disease 3.5 years post SARS-CoV-2 infection in an inner-city population in the Bronx

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 28, 2024

Objectives. Although patients with pre-existing Parkinson’s disease (PD) are at a higher risk of severe acute COVID-19 outcomes compared to matched controls, the long-term PD post SARS-CoV2 infection largely unknown. This study investigated clinical up 3.5 years post-infection in an inner-city population Bronx, New York. Methods. retrospective evaluated 3,512 Montefiore Health System Bronx (January 2016 July 2023), which serves large Black and Hispanic was epicenter early pandemic subsequent surges infections. status defined by positive polymerase-chain-reaction test. Comparisons were made without Outcomes post-index date all-cause mortality, major adverse cardiovascular events (MACE), altered mental status, fatigue, dyspnea, headache, psychosis, dementia, depression, anxiety, dysphagia, falls, orthostatic hypotension. Changes Levodopa, medication, prescriptions also tabulated. Adjusted hazard ratios (aHR) computed accounting for competing risks. Results. About 14% had similar demographics but prevalence comorbidities neurological disorders COVID-19. greater mortality (aHR = 1.58 [95% CI:1.03,2.41] P 0.03), MACE (HR 1.57[95% CI:1.19,2.07], P < 0.005), dyspnea 1.44 [1.11,1.87], 0.01), fatigue 1.49 [1.12,1.97] headache 1.35 [1.01,1.80] 0.04), fall 1.39 [1.01, 1.92] 0.04) index-date. Levodopa equivalent dose adjustment cohort non-COVID-19 (P 0.04). Conclusions. worse Patients who survive may benefit from heightened awareness close follow-up.

Language: Английский

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Long-Term outcomes of patients with a pre-existing neurological condition after SARS-CoV-2 infection

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 28, 2024

Objectives. This study investigated post COVID-19 outcomes of patients with pre-existing neurological conditions up to 3.5 years post-infection. Methods. retrospective consisted 1,664 (of which 1,320 had been hospitalized for acute COVID-19) and 8,985 non-COVID from the Montefiore Health System in Bronx (Jan-2016 Jul-2023). Primary were all-cause mortality major adverse cardiovascular events (MACE) post-COVID-19. Secondary depression, anxiety, fatigue, headache, sleep disturbances, altered mental status, dyspnea Cox proportional hazards model was used calculate adjusted hazard ratios event (MACE). Cumulative incidence function Fine-Gray sub-distribution analysis performed secondary outcomes. Results. Patients a disease more likely die (adjusted HR = 1.92 [CI:1.60, 2.30], P < 0.005), whereas non-hospitalized rate (aHR 1.08 [CI:0.65, 1.81], 0.76), compared patients. (hospitalized aHR 1.76 [CI:1.53, 2.03], 0.005; not COVID-19: 1.50 [CI:1.09, 2.05], 0.01) experience MACE Notably Blacks 1.49) Hispanics 1.35) higher risk MACE. Both develop cumulative disturbance, (p 0.05). Conclusions. who contracted have worse controls. Identifying at-risk individuals could enable diligent follow-up.

Language: Английский

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Long-Term Outcomes of Patients with Pre-Existing Essential Tremor After SARS-CoV-2 Infection

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2774 - 2774

Published: Dec. 10, 2024

Although COVID-19 has been linked to worse outcomes in patients with neurological disorders, its impact on those essential tremor (ET) remains unclear. To investigate clinical of ET and without three a half years post-pandemic. 1074 were evaluated this retrospective study the Montefiore Health System from January 2016 July 2023. Comparisons between positive SARS-CoV-2 polymerase chain reaction test made. Outcomes included post-index date major adverse cardiovascular events (MACEs), new-onset sleep disturbances, fatigue, dyspnea, first-time fall, anxiety, depression, headache, imbalance, mild cognitive impairment, all-cause mortality, adjusted hazard ratios (aHR) adjusting for covariates calculated. had higher prevalence pre-existing type-2 diabetes, anxiety compared COVID-19. was significantly associated risk MACEs, (aHR = 2.39 [1.49, 3.82]), disturbance, 2.12 [1.44, 3.13]), 1.83 [1.27, 2.65]), 1.98 [1.40, 2.80]), 4.76 [2.24, 10.14]), 3.66 [2.02, 6.64]), 2.38 [1.20, 4.70]). not mortality. In ET, increases several long-term health outcomes, but

Language: Английский

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Long COVID-19 outcomes of patients with pre-existing dementia

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Although COVID-19 has been linked to worse acute outcomes in patients with some neurodegenerative disorders, its long-term impact on dementia remains unclear.

Language: Английский

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New-onset gastrointestinal disorders in COVID-19 patients 3.5 years post-infection in the inner-city population in the Bronx

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 30, 2024

This study examined the incidence, characteristics, and risk factors of new gastrointestinal disorders (GID) associated with SARS-CoV-2 infection up to 3.5 years post-infection. retrospective included 35,102 COVID-19 patients 682,594 contemporary non-COVID-19 without past medical history GID (controls) from Montefiore Health System in Bronx (3/1/2020 7/31/2023). Comparisons were made unmatched propensity-matched (1:2) controls. The primary outcome was which peptic ulcer, inflammatory bowel disease, irritable syndrome, diverticulosis, diverticulitis, biliary disease. Multivariate Cox proportional hazards model analysis performed adjustment for covariates. There 2,228 (6.34%) positive who developed compared 38,928 (5.70%) had an elevated developing (adjusted HR = 1.18 (95% CI 1.12-1.25) controls, after adjusting confounders that smoking, obesity, diabetes, hypertension. These findings underscore need additional research follow-up at-risk individuals post infection.

Language: Английский

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Physical development of infants born to patients with COVID-19 during pregnancy: 2 years of age

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e18481 - e18481

Published: Nov. 12, 2024

Background SARS-CoV-2 infection during pregnancy and pandemic circumstances could negatively impact infant development. This study aimed to investigate the physical development, common pediatric illness incidence, healthcare utilization over first 2 years of life infants born COVID+ COVID- patients. Comparisons were also made with pre-pandemic. Methods is a retrospective observational at major academic health system in New York City. Participants include all birthing persons ( N = 758) without 9,345) from 03/01/2020 08/17/2022, pre-pandemic 3,221) 03/01/2017 08/17/2019, infants. Results There no differences weight, length, or head circumference curves between patients p > 0.05, repeated ANOVA). Annualized incidence occurrence similar groups. Compared infants, length (COVID-) was lower birth 9 months < 0.0001). Pandemic additionally had more adverse perinatal outcomes including increased stillbirth (0.75% vs . 0.12%, 0.0001) decreased gestational age (38.41 ± 2.71 38.68 2.55 weeks, Cohen’s d −0.10, 0.0001), birthweight (2,597 335 3,142 643 g, −1.06, (48.08 4.61 49.09 3.93 cm, −0.24, Conclusions Birthing persons’ status, profiles, affected outcomes, newborn utilization. These findings draw clinical attention need follow closely implement enrichment ensure optimal developmental outcomes.

Language: Английский

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New-onset cardiovascular diseases post SARS-CoV-2 infection in an urban population in the Bronx

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 28, 2024

Abstract This study investigated the incidence of new-onset cardiovascular disorders up to 3.5 years post SARS-CoV-2 infection for 56,400 individuals with COVID-19 and 1,093,904 contemporary controls without in Montefiore Health System (03/11/2020 07/01/2023). Outcomes were new major adverse event (MACE), arrhythmias, inflammatory heart disease, thrombosis, cerebrovascular disorders, ischemic disease other cardiac between 30 days (up to) index date. Results also compared a pre-pandemic cohort over similar observation duration ( N = 64,541). Cumulative hazard ratios adjusted competitive risks analyzed. Compared controls, hospitalized patients had significantly higher risk developing MACE (aHR 2.29, 95% confidence interval [2.27, 2.31], p < 0.001), arrhythmias 2.54[2.50, 2.58], 5.34[4.79, 5.96], 2.05[2.00, 2.11], 2.31[2.26, 2.35], thrombosis 4.25[4.15, 4.36], 1.89[1.86, 1.92], 0.001). Non-hospitalized slightly 1.04[1.03, 1.06], 1.10[1.08, 1.12], 2.29 [2.03, 2.59], 1.11[1.07, 1.15], 1.13], Race ethnicity mostly not associated increased > 0.05). aHRs as reference those reference. We concluded that incident patients, especially COVID-19, than controls. Identifying factors may draw clinical attention need careful follow-up at-risk individuals.

Language: Английский

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