Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 310, P. 120721 - 120721
Published: Feb. 20, 2023
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 426, P. 213548 - 213548
Published: Aug. 20, 2020
Language: Английский
Citations
173
Chemistry - A European Journal, Journal Year: 2019, Volume and Issue: 26(25), P. 5583 - 5591
Published: Dec. 27, 2019
As newly emerged crystalline porous materials, covalent organic frameworks (COFs) possess fascinating structures and some specific features such as modularity, crystallinity, porosity, stability, versatility, biocompatibility. Besides adsorption/separation, sensing, catalysis, energy applications, COFs have recently shown a promise in biomedical applications. This contribution provides an overview of the recent developments COF-based medicines cancer therapeutics, including drug delivery, photodynamic therapy (PDT), photothermal (PTT), combined therapy. Furthermore, major challenges developing trends this field are also discussed. These summarized discussed to help encourage further contributions emerging promising field.
Language: Английский
Citations
158
ACS Applied Materials & Interfaces, Journal Year: 2019, Volume and Issue: 12(3), P. 3279 - 3300
Published: Dec. 24, 2019
Among the different synthetic polymers developed for biomedical applications, poly(lactic-co-glycolic acid) (PLGA) has attracted considerable attention because of its excellent biocompatibility and biodegradability. Nanocomposites based on PLGA metal-based nanostructures (MNSs) have been employed extensively as an efficient strategy to improve structural functional properties polymer. The MNSs used impart new PLGA, such antimicrobial labeling. In present review, strategies available fabrication MNS/PLGA nanocomposites their applications in field will be discussed, beginning with a description preparation routes, activity, cytotoxicity concerns nanocomposites. these nanocomposites, carriers scaffolds tissue regeneration other therapies are subsequently reviewed. addition, potential advantages using treatment illnesses analyzed vitro vivo studies, support future research field.
Language: Английский
Citations
150
Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(6), P. 2031 - 2081
Published: Jan. 1, 2023
Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication
Language: Английский
Citations
132
Photodiagnosis and Photodynamic Therapy, Journal Year: 2021, Volume and Issue: 37, P. 102697 - 102697
Published: Dec. 20, 2021
Language: Английский
Citations
112
Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 308, P. 102753 - 102753
Published: Aug. 16, 2022
Photothermal therapy (PTT) is a promising alternative for benign or even malignant tumors. To improve the selective heating of tumor cells, target-specific photothermal conversion agents are often included, especially nanoparticles. Meanwhile, some indirect methods by manipulating radiation and heat delivery also adopted. Therefore, to gain clear understanding mechanism, controllability PTT, few issues need be clarified, including bioheat transfer, localized collective nanoparticles, etc. In this review, we provide an introduction typical transfer models along with dynamic thermophysical properties biological tissue. On basis, reviewed most recent advances in temperature control PTT from macroscale nanoscale. Most importantly, comprehensive effects nanoparticle clusters provided give insight into mechanism PPT microscale nanoscale point view.
Language: Английский
Citations
109
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: July 1, 2024
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.
Language: Английский
Citations
109
Biomaterials, Journal Year: 2021, Volume and Issue: 275, P. 120979 - 120979
Published: June 18, 2021
Language: Английский
Citations
107
Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)
Published: Nov. 19, 2022
Abstract Cancer is a major threat to human health. Among various treatment methods, precision therapy has received significant attention since the inception, due its ability efficiently inhibit tumor growth, while curtailing common shortcomings from conventional cancer treatment, leading towards enhanced survival rates. Particularly, organelle-targeted strategies enable precise accumulation of therapeutic agents in organelles, locally triggering organelle-mediated cell death signals which can greatly reduce threshold dosage and minimize side-effects. In this review, we comprehensively discuss history recent advances targeted therapies on specifically including nucleus, mitochondria, lysosomes endoplasmic reticulum, focusing organelle structures, signal pathways, design guidelines nanomedicines based intervention mechanisms. Furthermore, perspective future research clinical opportunities potential challenges oncology presented. Through demonstrating developments therapies, believe article further stimulate broader interests multidisciplinary technology development for enabling advanced their corresponding clinic translations.
Language: Английский
Citations
91
Exploration, Journal Year: 2023, Volume and Issue: 3(5)
Published: June 24, 2023
Abstract Tumor cells may be eliminated by increasing their temperature. This is achieved via photothermal therapy (PTT) penetrating the tumor tissue with near‐infrared light and converting energy into heat using agents. Copper sulfide nanoparticles (CuS NPs) are commonly used as PTAs in PTT. In this review, we aimed to discuss synergism between PTT CuS NPs other therapies such chemotherapy, radiotherapy, dynamic (photodynamic, chemodynamic, sonodynamic therapy), immunotherapy, gene therapy, gas magnetic hyperthermia. Furthermore, summarized results obtained a combination of two treatments at least therapies, one included therapies. Finally, benefits drawbacks various therapeutic options state art CuS‐based provided future directions for
Language: Английский
Citations
85