Nano Biomedicine and Engineering, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Exploration, Journal Year: 2023, Volume and Issue: 3(5)
Published: June 24, 2023
Abstract Tumor cells may be eliminated by increasing their temperature. This is achieved via photothermal therapy (PTT) penetrating the tumor tissue with near‐infrared light and converting energy into heat using agents. Copper sulfide nanoparticles (CuS NPs) are commonly used as PTAs in PTT. In this review, we aimed to discuss synergism between PTT CuS NPs other therapies such chemotherapy, radiotherapy, dynamic (photodynamic, chemodynamic, sonodynamic therapy), immunotherapy, gene therapy, gas magnetic hyperthermia. Furthermore, summarized results obtained a combination of two treatments at least therapies, one included therapies. Finally, benefits drawbacks various therapeutic options state art CuS‐based provided future directions for
Language: Английский
Citations
81
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 10998 - 11007
Published: April 29, 2024
Infections caused by bacteria pose a serious threat to public health, and there is need for numerous innovative, antibiotic-free antimicrobial medicines. Herein, we describe the synthesis of CuS/Co-ferrocene-MOF (CuS/Co-Fc-MOF) nanocomposites, formed coupling CuS nanoparticles (NPs) two-dimensional (2D) Co-Fc-MOF nanosheets, that constitutes an platform capable near-infrared (NIR) photothermal promotion chemodynamic antibacterial. 2D CuS/Co-Fc-MOF nanocomposites consist nanosheets with dimensions approximately 100–200 nm thicknesses 13.1–15.6 nm, where NPs, size about 8 are excellently dispersed on surface nanosheets. The diverse valence states cobalt iron in enable them undergo Fenton-like reactions H2O2, thus generating highly oxidizing ·OH therapy (CDT). utilization local plasmonic resonance effect NPs enables enhancement CDT activity under laser irradiation. More importantly, can achieve rapid (15 min) NIR laser-assisted killing both S. aureus E. coli bacterial infection microenvironment compared Therefore, be employed as promising nanoagent promote photothermally augmented antibacterial therapy.
Language: Английский
Citations
39
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 22, 2025
Photoimmunotherapy, which combines phototherapy with immunotherapy, exhibits significantly improved therapeutic effects compared mono-treatment regimens. However, its use is associated drawbacks, such as insufficient reactive oxygen species (ROS) production and uneven photosensitizer distribution. To address these issues, we developed a controllable, targeted nanosystem that enhances oxidative stress through multiple pathways, achieving synergistic photothermal, photodynamic, immunotherapy for tumor treatment. These nanoparticles (D/I@HST NPs) accurately target overexpressed transferrin receptors (TfRs) on the surface of cells surface-modified (Tf). After endocytosis, D/I@HST NPs generate ROS under 808-nm laser irradiation, breaking ROS-responsive crosslinking agent increasing drug release utilization. Tf also carries Fe3+, reduced to Fe2+ by iron reductase in acidic microenvironment (TME). Consequently, endoperoxide bridge structure dihydroartemisinin cleaved, causing additional generation. Furthermore, released IR-780 exerts both photodynamic photothermal effects, enhancing cell death. This multi-pathway amplification effect can trigger immunogenic death tumors, promoting relevant antigens damage-associated molecular patterns, thereby dendritic maturation sensitivity immunotherapy. Mature transmit signals T cells, infiltration activation, facilitating growth inhibition suppression lung metastasis. myeloid-derived suppressor decreases after In summary, this stress-amplified effectively inhibits reverses immunosuppressive microenvironment, provides new insights into combined phototherapy.
Language: Английский
Citations
2
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 678, P. 1088 - 1103
Published: Sept. 6, 2024
Language: Английский
Citations
15
Small, Journal Year: 2024, Volume and Issue: 20(26)
Published: Feb. 17, 2024
Abstract Photothermal therapy (PTT) is a new treatment modality for tumors. However, the efficient delivery of photothermal agents into tumors remains difficult, especially in hypoxic tumor regions. In this study, an approach to deliver melanin, natural agent, using genetically engineered bacteria image‐guided and immune developed. An Escherichia coli MG1655 transformed with recombinant plasmid harboring tyrosinase gene produce melanin nanoparticles. Melanin‐producing (MG1655‐M) are systemically administered 4T1 tumor‐bearing mice. The tumor‐targeting properties MG1655‐M environment integrate hypoxia targeting, photoacoustic imaging, therapeutic “all‐in‐one” manner. This eliminates need post‐modification achieve hypoxia‐targeted cancer therapy. Tumor growth significantly suppressed by irradiating 808 nm laser. Furthermore, strong antitumor immunity triggered PTT, thereby producing long‐term memory effects that effectively inhibit metastasis recurrence. work proposes guided melanin‐producing bacteria, which can offer broad potential applications treatment.
Language: Английский
Citations
13
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(34)
Published: April 29, 2024
Abstract Photothermal immunotherapy represents an effective approach for eliminating both local and metastatic tumors through priming of the tumor‐specific immune response. Cytosolic delivery double‐stranded DNA via pH‐responsive vehicles is recently verified to activate cyclic guanosine monophosphate–adenosine monophosphate (GMP‐AMP) synthase‐stimulator interferon genes (cGAS‐STING) pathway, which robust in activating innate adaptive antitumor immunity. Herein, multifunctional phototheranostics with excellent photothermal conversion capacity, second near‐infrared (NIR‐II) fluorescence, cGAS‐STING capacity are prepared by encapsulating fish testis conjugated boron dipyrromethene tetramers poly(lactic‐co‐glycolic acid) poly(ethylene glycol)‐b‐poly(lactic‐co‐glycolic a CaCO 3 ‐assisted double emulsion method. The obtained (coined DB 4 CaP NPs) after intravenous administration gradually accumulate tumor regions, as shown NIR‐II fluorescence imaging. Together 915 nm laser exposure, primary mice treated NPs could be effectively eradicated, complete response 83.3%. Furthermore, such synergize anti‐programmed cell death protein 1 suppress growth distant unirradiated rechallenged This study highlights promising strategy eradicating tumors, particularly invisible unresectable micronodules, imaging‐guided immunotherapy.
Language: Английский
Citations
9
Applied Materials Today, Journal Year: 2024, Volume and Issue: 38, P. 102215 - 102215
Published: May 3, 2024
Language: Английский
Citations
9
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(6), P. 3673 - 3692
Published: May 8, 2024
Copper (Cu) and Cu-based nanomaterials have received tremendous attention in recent years because of their unique physicochemical properties good biocompatibility the treatment various diseases, especially cancer. To date, researchers designed fabricated a variety integrated nanocomplexes with distinctive nanostructures applied them cancer therapy, mainly including chemotherapy, radiotherapy (RT), photothermal therapy (PTT), chemodynamic (CDT), photodynamic (PDT), cuproptosis-mediated etc. Due to limited effect single method, development composite diagnostic nanosystems that integrate PTT, CDT, PDT, other treatments is great significance offers potential for next generation anticancer nanomedicines. In view rapid field this review focuses on current state research nanomaterials, followed by discussion combined therapy. Moreover, challenges future prospects clinical translation are proposed provide some insights into design nanotherapeutic platforms.
Language: Английский
Citations
9
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: May 9, 2024
Mild photothermal therapy (PTT) is a spatiotemporally controllable method that utilizes the effect at relatively low temperatures (40-45 °C) to especially eliminate tumor tissues with negligible side effects on surrounding normal tissues. However, overexpression of heat shock protein 70 (HSP70) and limited single treatment drastically impede therapeutic efficacy. Herein, constructed multifunctional core-shell structured Ag-Cu@SiO
Language: Английский
Citations
9
Small, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
The self-assembly of hydrophobic organic phototherapeutic agents (OPTAs) with expansive planar structures into nanoparticles (NPs) represents a pivotal strategy to bolster their biocompatibility. However, the tight molecular packing within these NPs significantly influences generation reactive oxygen species (ROS) and photothermal conversion efficiency (PCE), posing substantial hurdle elevating efficacy photodynamic therapy (PDT) (PTT) for such NPs. In this article, three OPTAs by donor engineering are synthesized. Notably, 4,8-Bis (5-phenylthiophen-2-yl)-6-(2-ethylhexyl)-[1,2,5] thiadiazole [3,4-F] benzotriazole (BTBT), which incorporates benzene ring as donor, exhibits highest ROS optimal capability. To further augment overall phototheranostic potential BTBT NPs, glutathione (GSH)-driven disassembly is employed. This not only alleviates aggregation-caused quenching (ACQ) effect on but also facilitates enhanced free rotation. As result, production sees tenfold increase, temperature rises 8.3 °C, achieving PCE 77.03%. summary, versatile proposed that concurrently enhances performance both PDT PTT in OPTAs, while advancing state-of-the-art nasopharyngeal carcinoma (NPC) treatment.
Language: Английский
Citations
1