Mild photothermal/radiation therapy potentiates ferroptosis effect for ablation of breast cancer via MRI/PA imaging guided all-in-one strategy DOI Creative Commons
Zhe Zhang, Hsuan Lo,

Xingyang Zhao

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: May 8, 2023

Abstract Background Nanotheranostics advances anticancer management by providing therapeutic and diagnostic functions, that combine programmed cell death (PCD) initiation imaging-guided treatment, thus increasing the efficacy of tumor ablation efficiently fighting against cancer. However, mild photothermal/radiation therapy with precise mediating PCD in solid tumors, involving processes related to apoptosis ferroptosis, enhanced effect breast cancer inhibition is not fully understood. Results Herein, targeted peptide conjugated gold nano cages, iRGD-PEG/AuNCs@FePt NPs ternary metallic nanoparticles (Au@FePt NPs) were designed achieve photoacoustic imaging (PAI)/Magnetic resonance (MRI) guided synergistic therapy. Tumor-targeting Au@FePt forms reactive oxygen species (ROS), initiated X-ray-induced dynamic (XDT) collaboration photothermal (PTT), inducing ferroptosis-augmented realize effective antitumor therapeutics. The relatively high conversion ability increases temperature region hastens Fenton-like Especially, RNA sequencing found inducting pathway transcriptome profile. Conclusion combined XDT/PTT activate ferroptosis proteins tumors vitro vivo. PAI/MRI images demonstrated has real-time guidance for monitoring anti-cancer effect. Therefore, we have provided a multifunctional nanotheranostics modality limited side effects. Graphical

Language: Английский

A Forward Vision for Chemodynamic Therapy: Issues and Opportunities DOI
Peiran Zhao, Huiyan Li, Wenbo Bu

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(7)

Published: Jan. 17, 2023

Abstract Since the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great signs of progress have been made in field chemodynamic therapy (CDT). However, exact mechanism CDT is obscured by unique tumor chemical environment inevitable nanoparticle‐cell interactions, thus impeding further development. In this Scientific Perspective, significance clarified, complex deconstructed primitive biological research directions based on kinetics signaling pathways are discussed detail. Moreover, beneficial outlooks presented enlighten evolution next‐generation CDT. Hopefully, Perspective can inspire new ideas advances for provide a reference breaking down interdisciplinary barriers nanomedicine.

Language: Английский

Citations

187
Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors DOI
Li Zhang, Yue Liu, Haiyan Huang

et al.

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536

Published: Sept. 13, 2022

Language: Английский

Citations

108
Nanomaterials-modulated Fenton reactions: Strategies, chemodynamic therapy and future trends DOI
Junjie Qi,

Guoyong Jiang,

Yuqi Wan

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 466, P. 142960 - 142960

Published: April 15, 2023

Language: Английский

Citations

93
Current advances in metal–organic frameworks for cancer nanodynamic therapies DOI

Zhu Liu,

Ziwei Yan,

Yifan Di

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 497, P. 215434 - 215434

Published: Sept. 17, 2023

Language: Английский

Citations

43
Progress in nanomaterial-based synergistic photothermal-enhanced chemodynamic therapy in combating bacterial infections DOI Creative Commons
Panchanathan Manivasagan, Thavasyappan Thambi,

Ara Joe

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 144, P. 101292 - 101292

Published: April 6, 2024

The prevalence of multidrug-resistant (MDR) bacterial infections has emerged as a serious threat to clinical treatment and global human health, become one the most important challenges in therapy. Hence, there is an urgent need develop safe, effective, new antibacterial strategies based on multifunctional nanomaterials for accurate detection MDR infections. Chemodynamic therapy (CDT) emerging therapeutic strategy that uses Fenton/Fenton-like metal-based nanocatalysts convert hydrogen peroxide (H2O2) into hydroxyl radicals (OH) destroy Despite enormous potential CDT, single CDT limitations such low catalytic efficacy insufficient production H2O2. In this regard, can be combined with other strategies, photothermal (PTT), which effectively enhanced by PTT heating effect. Thus, rational combination nanoplatform been demonstrated highly efficient achieving better This review summarizes discusses latest advances photothermal-enhanced (PT/CDT) infection theranostics well advantages, challenges, future research directions applications, will inspire development PT/CDT

Language: Английский

Citations

35
Recent Trends in Bio-nanomaterials and Non-invasive Combinatorial Approaches of Photothermal Therapy against Cancer DOI Creative Commons

Nitisha Beniwal,

Anamika Verma,

Chandra Lekha Putta

et al.

Nanotheranostics, Journal Year: 2024, Volume and Issue: 8(2), P. 219 - 238

Published: Jan. 1, 2024

In 2020, approximately 10 million deaths worldwide were attributed to cancer, making it the primary cause of death globally.Photothermal therapy (PTT) is one novel ways treat and abolish cancer.PTT significantly impacts cancer theranostics compared other therapies like surgery, chemotherapy, radiotherapy due its remarkable binding capability tumor sites lower invasiveness into normal healthy tissues.PTT relies on photothermal agents (PTAs), which generate heat by absorbing near-infrared (NIR) light destroying cells.Several PTT remain longer in reticuloendothelial system (RES) induce toxicity, restricting their use biomedical field.To overcome this problem, usage biodegradable nano-photothermal required.This review has discussed mechanism action different types bio-nanomaterials used for PTT.We also focussed combinatorial effects with effect human health.The role LED lights mild hypothermia been briefly review.

Language: Английский

Citations

17
Implantable Microneedles Loaded with Nanoparticles Surface Engineered Escherichia coli for Efficient Eradication of Triple-Negative Breast Cancer Stem Cells DOI
Weinan Zhang,

Yechun Jiang,

Litao Liu

et al.

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Eliminating cancer stem cells (CSCs) is essential for the effective treatment of triple-negative breast (TNBC). This study synthesized Au@cerium-zinc composite core@shell nanoparticles (Au@Zn/CeO) that were subsequently conjugated with Escherichia coli (E. coli) to create engineered bacterium AZCE, which was then combined microneedle carriers and freeze-dried obtain AZCE-MN. Upon implantation into TNBC tumors, inherent properties E. facilitate AZCE penetrate extracellular matrix break through basement membrane, enabling delivery AZC CSCs-enriched regions deep within tumor. The released Zn2+ induces mitochondrial dysfunction amplifies reactive oxygen species (ROS) production. redox cycling between Ce3+/Ce4+ effectively depleted glutathione, further increased ROS generation. Under near-infrared laser irradiation, Au nanorods initiated photothermal therapy, ablating CSCs while amplifying catalytic reactions ionic effects. microneedle-mediated bacteria improved nanodrug penetration in tumor tissues, providing new insights clinical treatment.

Language: Английский

Citations

3
GSH-depleting and H2O2-self-supplying hybrid nanozymes for intensive catalytic antibacterial therapy by photothermal-augmented co-catalysis DOI
Junqin Li,

Wenhua Yi,

Yuze Luo

et al.

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 155, P. 588 - 600

Published: Oct. 31, 2022

Language: Английский

Citations

61
The translational paradigm of nanobiomaterials: Biological chemistry to modern applications DOI Creative Commons
Adrija Sinha, Faizan Zarreen Simnani, Dibyangshee Singh

et al.

Materials Today Bio, Journal Year: 2022, Volume and Issue: 17, P. 100463 - 100463

Published: Oct. 17, 2022

Recently nanotechnology has evolved as one of the most revolutionary technologies in world. It now become a multi-trillion-dollar business that covers production physical, chemical, and biological systems at scales ranging from atomic molecular levels to wide range industrial applications, such electronics, medicine, cosmetics. Nanobiomaterials synthesis are promising approaches produced various elements be it plants, bacteria, peptides, nucleic acids, etc. Owing better biocompatibility approach synthesis, they have gained immense attention biomedical field. Moreover, due their scaled-down sized property, nanobiomaterials exhibit remarkable features which make them potential candidate for different domains tissue engineering, materials science, pharmacology, biosensors, Miscellaneous characterization techniques been utilized nanobiomaterials. Currently, commercial transition research level form nano-scaffolds, implants, biosensors is stimulating whole field starting bio-mimetic nacres 3D printing, multiple nanofibers like silk fibers functionalizing drug delivery cancer therapy. The contribution single quantum dot nanoparticles tagging typically discipline genomics proteomics noteworthy. This review focuses on diverse emerging applications mechanistic advancements owing physiochemical properties leading growth industries measures. Alongside implementation several gene approaches, optical coding, photodynamic therapy, vapor sensing elaborately discussed this review. Different parameters based current challenges future perspectives also here.

Language: Английский

Citations

59
Engineering dual catalytic nanomedicine for autophagy-augmented and ferroptosis-involved cancer nanotherapy DOI
Zhifang Li, Chunmei Wang,

Chen Dai

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 287, P. 121668 - 121668

Published: July 5, 2022

Language: Английский

Citations

56