Injectable Functional Polymeric Cryogels for Biological Applications DOI
Duygu Çimen, Merve Asena Özbek, Nilay Bereli

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: May 29, 2024

In recent years, injectable cryogels have been frequently used in various biomedical applications such as tissue engineering, drug delivery, therapeutics, therapy, cell transplantation and immunotherapy. Cryogels, one of the biomaterials with 3D scaffold structures, important properties biocompatibility, physical resistance, macropore sensitivity. addition to being biocompatible, cryogels, consisting three-dimensional (3D) scaffolds physicochemical elasticity, hardness biological degradation, provide a structural support environment for development along attachment. addition, can be loaded therapeutic agents or cells engineering clinical studies. The purpose this review is explain chemical scaffolding, after explaining synthesis stages it thought guide make their use different areas more widespread future

Language: Английский

Mitigating metal-organic framework (MOF) toxicity for biomedical applications DOI Creative Commons
Paulina Wiśniewska, Józef T. Haponiuk, Mohammad Reza Saeb

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 471, P. 144400 - 144400

Published: June 25, 2023

Metal-organic frameworks (MOFs) are a novel class of crystalline porous materials, consisting metal ions and organic linkers. These hybrid materials possess exceptional porosity specific surface area, which have recently garnered significant interest due to their potential applications in gas separation storage, energy biomedical imaging, drug delivery. As MOFs being explored for applications, it is essential comprehensively assess toxicity. Although nearly ninety thousand been investigated, evaluating optimizing physico-chemical properties relevant biological systems remain critical clinical translation. In this review article, we first provide brief classification based on chemical structures. We then conduct comprehensive evaluation

Language: Английский

Citations

111
Progress in ATRP-derived materials for biomedical applications DOI Creative Commons
Mohsen Khodadadi Yazdi,

Payam Zarrintaj,

Mohammad Reza Saeb

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 143, P. 101248 - 101248

Published: Feb. 11, 2024

Language: Английский

Citations

18
Engineering multifunctional adhesive hydrogel patches for biomedical applications DOI Creative Commons
Aishik Chakraborty,

Shana Alexander,

Wei Luo

et al.

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(4)

Published: Aug. 18, 2023

Abstract Traditional patches, such as sticking plaster or acrylic adhesives used for over a hundred years, lack functionality. To address this issue of poor functionality, adhesive hydrogel patches have emerged an efficient bioactive multifunctional alternative. Hydrogels are three‐dimensional, water‐swellable, and polymeric materials closely resembling the native tissue architecture. The physicochemical properties hydrogels can be modified easily, allowing them to suitable various biomedical applications. Moreover, imparted through manipulations, making ideal candidates supplementing replacing traditional plaster. As result, sticky widely transdermal drug delivery even found commercial purposes. Beyond delivery, also applications in cardiac therapy, cancer research, biosensing, among other In mini‐review, we critically discuss challenges fabricating patches. Furthermore, introduce some chemical strategies involved with We review their emerging Finally, explore potential future flourishing field engineering delivery.

Language: Английский

Citations

33
Tailor-Made Polysaccharides for Biomedical Applications DOI Creative Commons
Mohsen Khodadadi Yazdi, Farzad Seidi, Aleksander Hejna

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 4193 - 4230

Published: July 3, 2024

Polysaccharides (PSAs) are carbohydrate-based macromolecules widely used in the biomedical field, either their pure form or blends/nanocomposites with other materials. The relationship between structure, properties, and functions has inspired scientists to design multifunctional PSAs for various applications by incorporating unique molecular structures targeted bulk properties. Multiple strategies, such as conjugation, grafting, cross-linking, functionalization, have been explored control mechanical electrical conductivity, hydrophilicity, degradability, rheological features, stimuli-responsiveness. For instance, custom-made known worldwide tissue engineering, drug/gene delivery, regenerative medicine. Furthermore, remarkable advancements supramolecular engineering chemistry paved way mission-oriented biomaterial synthesis fabrication of customized biomaterials. These materials can synergistically combine benefits biology tackle important questions. Herein, we categorize summarize based on methods, explore main strategies customize chemical structures. We then highlight properties using practical examples. Lastly, thoroughly describe tailor-made PSAs, along current existing challenges potential future directions.

Language: Английский

Citations

9
Propelling Minimally Invasive Tissue Regeneration with Next‐Era Injectable Pre‐Formed Scaffolds DOI

Junhan Liao,

Anastasia B. Timoshenko,

Domenic J. Cordova

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)

Published: June 6, 2024

The growing aging population, with its associated chronic diseases, underscores the urgency for effective tissue regeneration strategies. Biomaterials play a pivotal role in realm of reconstruction and regeneration, distinct shift toward minimally invasive (MI) treatments. This transition, fueled by engineered biomaterials, steers away from surgical procedures to embrace approaches offering reduced trauma, accelerated recovery, cost-effectiveness. In MI repair cargo delivery, various techniques are explored. While situ polymerization is prominent, it not without challenges. narrative review explores diverse fabrication methods, biofunctionalization injectable pre-formed scaffolds, focusing on their unique advantages. exhibiting compressibility, controlled injection, maintained mechanical integrity, emerge as promising alternative solutions conclusion this emphasizes importance interdisciplinary design facilitated synergizing fields materials science, advanced 3D biomanufacturing, mechanobiological studies, innovative regeneration.

Language: Английский

Citations

8
Copper-MOF and tannic acid-empowered composite cryogel as a skin substitute for accelerated deep wound healing DOI
Hemant Singh,

Aniruddha Dan,

B. Prasanna Kumari

et al.

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 164, P. 213983 - 213983

Published: Aug. 3, 2024

Language: Английский

Citations

6
Synthesis and Characterization of Folic Acid-Functionalized DPLA-co-PEG Nanomicelles for the Targeted Delivery of Letrozole DOI Creative Commons
Neda Rostami, Mohammad Mahmoudi Gomari, Majid Abdouss

et al.

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(5), P. 1806 - 1815

Published: April 24, 2023

An effective treatment for hormone-dependent breast cancer is chemotherapy using cytotoxic agents such as letrozole (LTZ). However, most anticancer drugs, including LTZ, are classified class IV biopharmaceuticals, which associated with low water solubility, poor bioavailability, and significant toxicity. As a result, developing targeted delivery system LTZ critical overcoming these challenges limitations. Here, biodegradable LTZ-loaded nanocarriers were synthesized by solvent emulsification evaporation nanomicelles prepared dodecanol-polylactic acid-co-polyethylene glycol (DPLA-co-PEG). Furthermore, cell-targeting folic acid (FA) was conjugated into the to achieve more safer treatment. During our investigation, DPLA-co-PEG DPLA-co-PEG-FA displayed uniform spherical morphology. The average diameters of 86.5 241.3 nm, respectively. Our preliminary data suggest that both nanoformulations cytocompatible, ≥90% cell viability across all concentrations tested. In addition, amphiphilic nature led high drug loading dispersion in water, resulting extended release up 50 h. According Higuchi model, functionalized FA have greater potential controlled target cells. This model confirmed experimentally, LTZ-containing significantly specifically (up 90% death) toward MCF-7 cells, human line, when compared free DPLA-co-PEG. half-maximal inhibitory concentration (IC50) 87 ± 1 nM achieved cells exposed DPLA-co-PEG-FA, whereas higher doses 125 2 100 required DPLA-co-PEG, Collectively, represents promising nanosized controllably drugs chemotherapeutics.

Language: Английский

Citations

14
Hypoxia-inducing cryogels uncover key cancer-immune cell interactions in an oxygen-deficient tumor microenvironment DOI Creative Commons
Thibault Colombani, Zachary J. Rogers, Khushbu Bhatt

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 29, P. 279 - 295

Published: Aug. 9, 2023

Hypoxia is a major factor shaping the immune landscape, and several cancer models have been developed to emulate hypoxic tumors. However, date, they still limitations, such as lack of reproducibility, inadequate biophysical cues, limited cell infiltration, poor oxygen (O

Language: Английский

Citations

14
A Multifunctional Tissue‐Engineering Hydrogel Aimed to Regulate Bacterial Ferroptosis‐Like Death and Overcoming Infection Toward Bone Remodeling DOI Creative Commons
Renjie Lu,

Zhiyuan Luo,

Yuanyuan Zhang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 19, 2024

Infection is the most common complication after orthopedic surgery and can result in prolonged ailments such as chronic wounds, enlarged bone defects, osteomyelitis. Iron, which essential for bacterial metabolism immune cell functions, extremely important. Bacteria harness iron from nearby cells to promote biofilm formation, ensuring their survival. Iron deficiency within infection microenvironment (IME) consequently hampers macrophage function, enabling further dissemination of hindering polarization M2 phenotype. Therefore, a novel approach proposed regulate polarization, aiming restore inflammatory environment. A composite hydrogel derived natural polymers developed address infections manage macrophages. This IME-responsive hydrogel, named FCL-ECMH, synthesized by encapsulating vermiculite functional core layers decellularized extracellular matrix hydrogel. It noteworthy that FCL-ECMH produce reactive oxygen species IME. Supplementary photothermal treatment enhances uptake, leading ferroptosis-like death. process also rejuvenates iron-enriched macrophages around IME, thereby enhancing antibacterial tissue repair functions. In vivo experiments confirmed repair-promoting capabilities indicating its potential clinical applications.

Language: Английский

Citations

5
Surface functionalized cryogels – characterization methods, recent progress in preparation and application DOI Creative Commons
Florian F. Behrendt, Michael Gottschaldt, Ulrich S. Schubert

et al.

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(19), P. 4600 - 4637

Published: Jan. 1, 2024

Cryogel applicability is strongly determined by the respective functionalization which can be evaluated directly or indirectly using different analytical techniques. This also helps to ensure a high reproducibility among produced materials.

Language: Английский

Citations

5