Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 379 - 405
Published: Jan. 1, 2024
Language: Английский
Macromol—A Journal of Macromolecular Research, Journal Year: 2024, Volume and Issue: 4(2), P. 320 - 355
Published: May 15, 2024
The delivery of therapeutical molecules through the skin, particularly to its deeper layers, is impaired due stratum corneum layer, which acts as a barrier foreign substances. Thus, for past years, scientists have focused on development more efficient methods deliver skin distinct layers. Microneedles, new class biomedical devices, consist an array microscale needles. This particular device has been drawing attention ability breach corneum, forming micro-conduits facilitate passage molecules. microneedle several advantages over conventional methods, such better medication adherence, easiness, and painless self-administration. Moreover, it possible swiftly or time. Microneedles can vary in shape, size, composition. design process must take into account factors, like location delivery, material, manufacturing process. used large number fields from drug vaccine application cosmetics, therapy, diagnoses, tissue engineering, sample extraction, cancer research, wound healing, among others.
Language: Английский
Citations
28
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 4, 2024
Abstract Infected wound healing remains a challenging task in clinical practice due to several factors: (I) drug-resistant infections caused by various pathogens, (II) persistent inflammation that hinders tissue regeneration and (III) the ability of pathogens persist intracellularly evade antibiotic treatment. Microneedle patches (MNs), recognized for their effecacious painless subcutaneous drug delivery, could greatly enhance if integrated with antibacterial functionality regenerative potential. A multifunctional agent subcellular targeting capability contained novel components, upon loading onto MNs, yield excellent therapeutic effects on infections. In this study, we sythesised zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs) loaded low molecular weight fucoidan (Fu) further coating hyaluronic acid (HA), obtained HAZ@Fu NPs, which Methicillin-resistant Staphylococcus aureus (MRSA) growth promotes M2 polarization macrophages. We mixed NPs photocrosslinked gelatin methacryloyl (GelMA) it into tips MNs (HAZ@Fu MNs), administered mice model MRSA-infected full-thickness cutaneous wounds. are able penetrate skin barrier, delivering dermal layer. Since cells within infected tissues extensively express HA receptor CD44, also confirmed endows target MRSA level. vitro vivo murine studies have demonstrated capable deep layers. And facilitated coating, surviving at The effective such as zinc ions, Fu, sustainably released, contributes activity, mitigates inflammation, epithelial fosters neovascularization. Through RNA sequencing macrophages post co-culture HAZ@Fu, Kyoto Encyclopedia Genes Genomes (KEGG) pathway analysis reveals biological functionalities associated potentially be through PI3K-Akt pathway. results indicate synergistic application biodegradable may serve significant adjunct treatment intricate mechanisms driving its merit investigation.
Language: Английский
Citations
19
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(12)
Published: Jan. 23, 2024
Abstract Senile wound healing risks a variety of health complications and makes both economic psychological burdens on patients greatly. Poor activity aged dermal fibroblasts (A‐FBs) local disordered immunoreaction in the deep dermis contribute to delayed healing. Therefore, locally complex microenvironment requires additional processing. Herein, novel double‐layer hyaluronic acid methacrylate (HAMA)/polyvinyl alcohol (PVA) microneedle patch (MNP) coated by young fibroblast‐derived exosomes (Y‐EXOs) (Y‐EXOs@HAMA/PVA MNP) is presented for drug delivery, immunoregulation. A spraying freeze‐drying method applied keeping bioactivity nanovesicles. An ideal loading Y‐EXOs enhanced strength penetration have realized after circulation times. The Y‐EXOs@HAMA/PVA MNP shows an excellent influence skin with active A‐FBs, more deposition collagen less production IL‐17A compared application (A‐EXOs). Moreover, content microRNAs A‐EXOs are sequenced further study. This study initiatively demonstrates that effective function anti‐aging anti‐inflammation expected as strategy delivery promoting hard future clinical application.
Language: Английский
Citations
13
Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Language: Английский
Citations
1
Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 233, P. 113636 - 113636
Published: Nov. 11, 2023
Language: Английский
Citations
21
Microelectronic Engineering, Journal Year: 2024, Volume and Issue: 292, P. 112228 - 112228
Published: June 25, 2024
Language: Английский
Citations
8
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: June 12, 2024
Abstract Coated microneedles (CMNs) are a minimally invasive platform for immediate‐release transdermal drug delivery. However, the practical applications of CMNs have been significantly hindered by challenges associated with complex formulations, single function, and limited loading capacity. This study has developed spiderweb‐shaped iron‐coordinated polymeric nanowire network (Fe‐IDA NWs). The resulting Fe‐IDA NWs endowed certain viscosity due to synergy multiple supramolecular interactions. allows them replace traditional thickeners as microneedle coatings. NWs‐coated MNs) display rapid disintegration in skin model, which also enables swift diffusion their payloads into deeper layers. Additionally, MNs exhibit desirable enzymatic activity potential antibacterial ability. Thus, can enhance therapeutic efficacy against wound infection through synergistic effects, avoid overly complicated formulation release nontherapeutic molecules conventional CMNs. As proof‐of‐concept, loaded chlorin e6 showed chemodynamic‐photodynamic effect methicillin‐resistant Staphylococcus aureus‐infected model mice. Collectively, this work significant implications future CMNs‐based delivery systems expands application fields metal coordination polymer (MCP) materials.
Language: Английский
Citations
6
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
Abstract The healing of bacterial biofilm‐infected wounds is a complex process, and the construction emerging therapeutic modalities that regulate microenvironment to magnify effects reduce biotoxicity still highly challenging. Herein, an engineered microneedle (MN) patch reported mediate efficient delivery black phosphorus nanosheets (BP NSs) copper peroxide nanodots (CP NDs) for dual nanodynamic sterilization methicillin‐resistant staphylococcus aureus (MRSA)‐infected wound healing. Results demonstrate system can eliminate biofilm, cytotoxicity, promote angiogenesis tissue regeneration by multiple advantages chemodynamic therapy (CDT), enhanced photodynamic (PDT), improved degradation process from BP NSs phosphate promoting cell proliferation. Notably, balance between excellent stability rapid degradability maintained, mechanism vividly elucidated density functional theory (DFT)‐based molecular dynamics (MD) calculations. Furthermore, transcriptional changes treated MRSA‐infected skin are studied using RNA‐seq technology reveal potential mechanism. As envisaged, proposed MN provides safe, easy, also effective approach achieve temporal regulation wounds.
Language: Английский
Citations
0
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1755 - 1772
Published: Feb. 1, 2025
Purpose: Microinjury can trigger in situ tissue repair. Bone transport consists of continuous microinjuries/microfracture and induces bone formation angiogenesis. Tibial cortex transverse (TTT) was found to promote angiogenesis at the foot healing diabetic ulcers (DFUs). However, underlying mechanism remains largely unknown. Methods: We divided 72 Sprague-Dawley rats with DFUs into control, sham, TTT groups. Wound measurement histology were performed evaluate wound processes. Enzyme-linked immunosorbent assay, flow cytometry, immunohistochemistry, Western Blot used assess activity endothelial progenitor cells (EPCs) Ras/Raf/MEK/ERK signaling pathway. Results: accelerated healing, improved epidermal continuity, increased dermal thickness group than control sham Higher levels serum TGF-β 1, PDGF-BB, VEGF detected group. These changes parallel expression wounds frequency EPCs both marrow peripheral circulation, which implied that secreted proliferation migration wounds. The CD31 + cells, SMA-α pathway higher Conclusion: findings showed enhanced production growth factors turn activated EPC through pathway, ultimately contributing DFU healing. Based on these findings, we proposed a theory remote microinjuries repair target tissues (ie, microinjury-induced repair, MIRR). Future studies are needed validate this theory. Keywords: microinjury, transport, tibial ulcer,
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 10, 2025
Abstract The skin microenvironment is a highly intricate and dynamic system, characterized by an acidic pH, diverse microbiota, various metabolites, numerous enzymes, creating both challenges opportunities for the development of innovative drug delivery systems. Dissolving Microneedles (MNs) have emerged as promising, pain‐free alternative to conventional invasive injections, offering ability deliver therapeutics through gradual degradation within skin's interstitial fluids. Building upon unique properties dissolving MNs, novel concept introduced wherein MNs serve in situ chemical reaction chambers. In this framework, can reactants or catalysts skin, enabling initiation specific reactions, such prodrug activation targeted therapy, harmful enhanced synthesis beneficial molecules. Moreover, review systematically explores potential chambers, discussing key aspects their sustained release mechanisms, design strategies, range therapeutic applications. Finally, forward‐looking perspective provided on future addressing broader clinical translation application personalized medicine.
Language: Английский
Citations
0