ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(51), P. 59155 - 59164
Published: Dec. 15, 2023
The
delivery
of
cell
impermeable
exogenous
material
into
live
cells
by
external
stimuli
is
critical
for
both
biological
research
and
therapeutic
applications.
Although
electroporation-based
foreign
materials
inside
the
a
powerful
approach,
viability
often
compromised
due
to
requirement
high
voltage.
Here,
we
report
piezoelectric
hydroxyapatite
nanowire-embedded
poly(vinylidene
fluoride)
(PVDF)
film
ultrasonic
adherent
cells.
We
found
that
9
wt
%
loading
nanowires
PVDF
can
enhance
property
2-3
times
(with
constant
value
58
pm/V)
than
pure
PVDF/nanowire,
which
comparable
commonly
known
ceramics.
These
films
harvest
mechanical
as
well
ultrasound-based
energy
produce
electrical
potential
up
2
V.
This
biocompatible
be
used
grow
on
top
it
subsequent
application
ultrasound
exert
electric
voltage
membrane.
exposure
adhered
leads
reversible
pore
formation
membrane
offers
intracellular
FITC-dextran
with
75%
efficiency.
developed
film-based
electroporation
wireless
in
remote
areas.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Antibiotic-resistant
bacteria
often
cause
lethal
infections
in
both
the
surficial
and
deep
organs
of
humans.
Failure
antibiotics
resistant
leads
to
more
effective
alternative
therapies,
like
spatiotemporally
controllable
piezodynamic
therapy
(PZDT)
with
penetration.
Currently,
PZDT
demands
further
investigation
for
improved
treatment
outcomes
corresponding
therapeutic
mechanisms.
Herein,
a
nanocomposite
cloaked
is
reported
biomimetic
coating
TLR-upregulated
macrophage
membrane
targeted
against
MRSA-induced
skin
wound
infection
osteomyelitis,
representing
models,
respectively.
To
boost
efficacy,
crystal
defect
engineering
applied
by
impregnating
Fe2+
into
bismuth
oxy-iodide
nanosheets
increase
defects.
This
results
significantly
higher
piezoelectric
coefficient
than
previous
reports,
contributing
an
amplified
reactive
oxygen
species
generation
bacterial
killing.
More
importantly,
notable
effect
not
only
re-programs
macrophages
anti-inflammatory
M2
phenotype
accelerating
healing
but
also
stimulates
opening
piezo-stimulated
Ca2+
channels
boosts
differentiation
mesenchymal
stem
cells
osteoblasts
expediting
bone
tissue
repair
osteomyelitis
model.
Moreover,
Fe-doping
supplements
T2-magnetic
resonance
imaging
real-time
visualization
distribution.
theranostic
system
opens
new
avenue
future
drug-resistant
bacteria-caused
diseases.
Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
11(6), P. 1994 - 2019
Published: Jan. 1, 2023
This
work
demonstrates
different
stimulus-based
antibacterial
treatment
strategies
for
both
resistant
bacteria
and
biofilms.
Moreover,
a
future
perspective
has
been
illustrated
making
these
modalities
clinically
feasible.
Chemical Engineering Journal Advances,
Journal Year:
2023,
Volume and Issue:
14, P. 100477 - 100477
Published: March 4, 2023
For
the
very
first
time,
effect
of
frequency
on
piezocatalytic
degradation
dyes
has
been
systematically
evaluated.
To
achieve
this,
a
combination
systems
and
experimental
setups
operating
at
different
ultrasonic
frequencies
ranging
from
20
kHz
up
to
1
MHz
were
used.
In
addition,
power
was
investigated
low
higher
576
shed
more
light
into
controversial
discussion
surrounding
'true'
mechanisms
behind
piezocatalysis.
The
results
revealed
that
mechanical
effects
derived
acoustic
cavitation,
predominant
lower
(<100
kHz),
indeed
enhanced
dye,
Rhodamine
B,
some
extent
(from
53%
64%
RhB
after
2
h).
However,
it
again
demonstrated
sonochemical
production
radicals
remains
significant
contributor
for
overall
dye.
Moreover,
(>100
chemical
cavitation
so
remarkable,
raised
question
whether
piezocatalyst
is
really
necessary
when
optimisation
may
be
enough
sonochemistry
fully
degrade
organic
pollutants
fast
rate
(pseudo
first-order
reaction
constant
0.037
min−1).
Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
95(13), P. 5807 - 5814
Published: March 22, 2023
Accurate
and
in-time
detection
of
bacteria
conduces
to
preventing
their
rapid
spread
around
the
environment,
while
a
nucleic
acid
test
(NAT)
is
powerful
tool
for
early
diagnosis
pathogens.
Herein,
we
propose
hybridization
chain
reaction
(HCR)-mediated
multisite
exonuclease
III
(Exo-III)
amplification
strategy
(HCR/Exo-III
amplifier)
achieve
one-pot
ultrasensitive
isothermal
bacterial
16S
rRNA
portable
fluorescence
device
(PFD)
directly
read
signals
in
lateral
flow
assay
(LFA).
In
detail,
target-initiated
HCR
products
present
multiple
binding
sites
triggering
Exo-III
amplifier
that
produces
numerous
target
amplicons.
Following
that,
amplicons
travel
up
on
strip
bridge
between
DNA-CdTe/CdS
probes
capture
DNA
form
positive
line.
After
inserted
into
PFD
accomplish
signal
reading.
The
constructed
HCR/Exo-III
amplifier-based
PFD-LFA
implemented
simultaneous
specific
three
with
limit
few
tenths
fM
synthetic
fragments
dozens
CFU/mL
Staphylococcus
aureus,
Listeria
monocytogenes,
Salmonella
typhimurium
pure
cultures.
sensing
platform
features
amplification,
convenient
operation,
good
economy,
displaying
great
potential
on-site
testing
toward
analytes.
