Biomedical applications of stimuli‐responsive nanomaterials DOI Creative Commons
Xiaojie Chen, Di Wu, Zhong Chen

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 20, 2024

Abstract Nanomaterials have aroused great interests in drug delivery due to their nanoscale structure, facile modifiability, and multifunctional physicochemical properties. Currently, stimuli‐responsive nanomaterials that can respond endogenous or exogenous stimulus display strong potentials biomedical applications. In comparison with conventional nanomaterials, improve therapeutic efficiency reduce the toxicity of drugs toward normal tissues through specific targeting on‐demand release at pathological sites. this review, we summarize responsive mechanism a variety stimulus, including pH, redox, enzymes within microenvironment, as well such thermal effect, magnetic field, light, ultrasound. After that, applications (e.g., delivery, imaging, theranostics) diverse array common diseases, cardiovascular cancer, neurological disorders, inflammation, bacterial infection, are presented discussed. Finally, remaining challenges outlooks future research directions for also We hope review provide valuable guidance developing accelerate diseases diagnosis treatment.

Language: Английский

Advances in Nanotechnology for Biofilm Inhibition DOI Creative Commons
Lokender Kumar, Monish Bisen, Kusum Harjai

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(24), P. 21391 - 21409

Published: June 7, 2023

Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible range multidrug-resistant pathogens. These pathogens show reduced susceptibility intracellular survival. However, current methods for treating biofilms, such smart materials targeted drug delivery systems, not been found effective in preventing biofilm formation. To address this challenge, nanotechnology provided innovative solutions formation by clinically relevant Recent advances nanotechnological strategies, including metallic nanoparticles, functionalized dendrimers, polymeric cyclodextrin-based delivery, solid lipid polymer conjugates, liposomes, may provide valuable technological against infectious diseases. Therefore, it is imperative conduct comprehensive review summarize the recent advancements limitations advanced nanotechnologies. present Review encompasses summary agents, mechanisms that lead formation, impact on human health. In nutshell, offers survey managing infections. A detailed presentation how these strategies improve control prevent key objective mechanisms, applications, prospects nanotechnologies better understanding

Language: Английский

Citations

76
Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration DOI Creative Commons
Amal George Kurian, Rajendra K. Singh,

Varsha Sagar

et al.

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Language: Английский

Citations

38
Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies DOI

Huilong Xin,

Yuanyuan Liu, Yinan Xiao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 23, 2024

Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.

Language: Английский

Citations

33
Design and optimization of ε-poly-l-lysine with specific functions for diverse applications DOI
Yi Wang,

Limin Wang,

Yangfan Hu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129513 - 129513

Published: Jan. 22, 2024

Language: Английский

Citations

10
Crystal growth mediated physicochemical properties enhancement of CoMnO3 perovskite nanomaterials and its efficient degradation of organic dyes and pathogenic bacteria under mechanical stimuli DOI
Indrajit Mondal,

Piyali Halder,

Anuja Chatterjee

et al.

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(2), P. 112385 - 112385

Published: March 6, 2024

Language: Английский

Citations

10
Nanomaterials as multimodal photothermal agents (PTAs) against ‘Superbugs’ DOI
Shubham Roy,

Jhilik Roy,

Bing Guo

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(11), P. 2287 - 2306

Published: Jan. 1, 2023

Superbugs, also known as multidrug-resistant bacteria, have become a lethal and persistent threat due to their unresponsiveness toward conventional antibiotics. The main reason for this is that superbugs can rapidly mutate restrict any foreign drug/molecule in vicinity. Herein, nanomaterial-mediated therapies set path shown burgeoning efficiency the ablation of superbugs. Notably, treatment modalities like photothermal therapy (PTT) prominence killing bacteria with ability generate local heat shock-mediated hyperthermia such species. However, has some serious limitations, high cost, complexity, even toxicity extent. Hence, it important resolve shortcomings PTTs they provide substantial tissue penetration. This why multimodal emerged taken over domain research past few years. In work, we summarized critically reviewed exceptional works recent times provided perspective enhance efficiencies. Profoundly, discuss design rationales novel agents (PTAs) shed light on mechanisms. Finally, challenges PTT-derived are presented, capable synergistic bactericidal prospects anticipated.

Language: Английский

Citations

19
Collagen–Hyaluronic Acid Composite Hydrogels with Applications for Chronic Diabetic Wound Repair DOI

Mujiao Liang,

Lina Dong, Zhongwei Guo

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(9), P. 5376 - 5388

Published: Aug. 19, 2023

Chronic diabetic wounds have become a major healthcare challenge worldwide. Improper treatment may lead to serious complications. Current methods including biological and physical skin grafting limitations disadvantages, such as poor efficacy, inconvenience of use, high cost. Therefore, developing more effective feasible is great significance for the repair chronic wounds. Hydrogels can be designed serve multiple functions promote Furthermore, 3D bioprinting enables hydrogel customization fit wounds, thus facilitating healing process. This paper reports study printing collagen–hyaluronic acid composite hydrogels with application wound repair. In situ printed were developed by macromolecular crosslinking network using methacrylated recombinant human collagen (RHCMA) hyaluronic (HAMA), both which respond ultraviolet (UV) irradiation. The also loaded silver nanoclusters (AgNCs) ultra-small-size nanoparticles, advantages deep penetration ability broad-spectrum high-efficiency antibacterial properties. results this show that RHCMA, HAMA, AgNCs (RHAg) present good UV responsiveness, porosity, mechanical properties, printability, biocompatibility, all are beneficial healing. further RHAg not only effectively inhibited Staphylococcus aureus Pseudomonas aeruginosa but promoted proliferation migration fibroblasts in vitro tissue regeneration deposition vivo, producing desirable effect used an functional biomaterial

Language: Английский

Citations

17
Breaking the barrier: Nanoparticle-enhanced radiotherapy as the new vanguard in brain tumor treatment DOI Creative Commons
Shi Liu,

Meng Jiao Li,

Bing Liang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 3, 2024

The pursuit of effective treatments for brain tumors has increasingly focused on the promising area nanoparticle-enhanced radiotherapy (NERT). This review elucidates context and significance NERT, with a particular emphasis its application in tumor therapy—a field where traditional often encounter obstacles due to blood-brain barrier (BBB) cells’ inherent resistance. aims this include synthesizing recent advancements, analyzing action mechanisms, assessing clinical potential challenges associated nanoparticle (NP) use enhancement. Preliminary preclinical studies have established foundation demonstrating that nanoparticles (NPs) can serve as radiosensitizers, thereby intensifying radiotherapy’s efficacy. Investigations into various NP types, such metallic, magnetic, polymeric, each unveiled distinct interactions ionizing radiation, leading an augmented destruction cells. These interactions, encompassing physical dose enhancement biological chemical radio sensitization, are crucial NERT strategy. Although their early phases, initial trials shown results terms response rates survival, albeit mindful consideration toxicity profiles. examines pivotal affirming NERT’s efficacy safety. NPs revolutionize by overcoming targeted delivery, reducing off-target effects, harmonizing other modalities. Future directions refining formulations, personalizing therapies, navigating regulatory pathways. holds promise transform treatment provide hope patients.

Language: Английский

Citations

5
Nanomaterials-mediated on-demand and precise antibacterial therapies DOI Creative Commons

Shi Cheng,

Qihui Wang, Manlin Qi

et al.

Materials & Design, Journal Year: 2023, Volume and Issue: 230, P. 111982 - 111982

Published: May 5, 2023

Bacterial infection is a series of pathological changes caused by bacteria invading the host and interacting with body. Nowadays, bacterial remains major public health issue severe threat to human life health. Traditional antibiotic therapy less effective against biofilms easily causes resistance, which has urged development substitute antibacterial strategy. Recently, nanomaterials have attracted much attention. However, traditional face some problems insufficient drug concentration at infectious sites toxicity extravasated damage healthy tissues. On contrary, based on advanced on-demand precise strategies reduce biological effectively while improving germicidal efficacy, since these type nanodrugs higher spatiotemporal controllability. Currently, smart stimuli-responsive targeting been successfully constructed achieve therapies. This review focuses mechanisms, working principles antimicrobial properties diverse nanoparticles strategies. Meanwhile, strengths inferiorities different discussed. Finally, this concludes our opinions future directions for exploiting next-generation

Language: Английский

Citations

12
Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment DOI
Siyuan Yang,

Yingnan Song,

Heng Dong

et al.

Small, Journal Year: 2023, Volume and Issue: 19(52)

Published: Aug. 30, 2023

Abstract Antibacterial theranostic nanoplatforms, which integrate diagnostic and therapeutic properties, exhibit gigantic application prospects in precision medicine. However, traditional nanoplatforms usually present an always‐on signal output, leads to poor specificity or selectivity the treatment of bacterial infections. To address this challenge, stimuli‐actuated turn‐on are developed for simultaneous activation signals (e.g., fluorescent, photoacoustic, magnetic signals) initiation antibacterial treatment. Specifically, by combining infection microenvironment‐responsive visual activity, these exert both higher accurate diagnosis rates more effective effects. In review, imaging strategies that commonly used clinic first briefly introduced. Next, recent progress treating infectious diseases is summarized detail. Finally, current bottlenecks future opportunities also outlined discussed.

Language: Английский

Citations

12